Basic Information:

  VIRBase ID:  

VHID00508101

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          G3BP1:  NM_005754     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	G3BP1
miRBase Accession/Entrez ID	MIMAT0001581	10146
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	G3BP//HDH-VIII

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	G3BP1	chr5:151182223(+) A-I      intronic chr5:151182221(+) A-I      intronic chr5:151181521(+) A-I      intronic chr5:151183128(+) A-I      intronic chr5:151182283(+) A-I      intronic chr5:151172414(+) A-I      intronic chr5:151172799(+) A-I      intronic chr5:151182473(+) A-I      intronic chr5:151182439(+) A-I      intronic chr5:151182400(+) A-I      intronic chr5:151182392(+) A-I      intronic chr5:151182390(+) A-I      intronic chr5:151183182(+) A-I      intronic chr5:151171491(+) A-I      intronic chr5:151163069(+) A-I      intronic chr5:151163068(+) A-I      intronic chr5:151158471(+) A-I      intronic chr5:151181432(+) A-I      intronic chr5:151181462(+) A-I      intronic chr5:151182332(+) A-I      intronic chr5:151182476(+) A-I      intronic chr5:151158458(+) A-I      intronic chr5:151182331(+) A-I      intronic chr5:151182317(+) A-I      intronic chr5:151182307(+) A-I      intronic chr5:151182306(+) A-I      intronic chr5:151183335(+) A-I      intronic chr5:151183293(+) A-I      intronic chr5:151182240(+) A-I      intronic chr5:151183153(+) A-I      intronic chr5:151172294(+) A-I      intronic chr5:151182344(+) A-I      intronic chr5:151157169(+) A-I      intronic chr5:151172879(+) A-I      intronic chr5:151181395(+) A-I      intronic chr5:151158102(+) A-I      intronic chr5:151158144(+) A-I      intronic chr5:151158459(+) A-I      intronic chr5:151158460(+) A-I      intronic chr5:151158462(+) A-I      intronic chr5:151158160(+) A-I      intronic chr5:151158340(+) A-I      intronic chr5:151158385(+) A-I      intronic chr5:151181419(+) A-I      intronic chr5:151158456(+) A-I      intronic chr5:151172188(+) A-I      intronic chr5:151165807(+) A-I      intronic chr5:151171470(+) A-I      intronic chr5:151158498(+) A-I      intronic chr5:151158530(+) A-I      intronic chr5:151172307(+) A-I      intronic chr5:151181476(+) A-I      intronic chr5:151164688(+) A-I      intronic chr5:151173468(+) A-I      intronic chr5:151182987(+) A-I      intronic chr5:151173559(+) A-I      intronic chr5:151158120(+) A-I      intronic chr5:151182489(+) A-I      intronic chr5:151181505(+) A-I      intronic chr5:151172226(+) A-I      intronic chr5:151183184(+) A-I      intronic chr5:151188483(+) A-I      3'UTR chr5:151188488(+) A-I      3'UTR chr5:151186385(+) A-I      3'UTR chr5:151173460(+) A-I      intronic chr5:151174726(+) A-I      intronic chr5:151172891(+) A-I      intronic chr5:151172809(+) A-I      intronic chr5:151181583(+) A-I      intronic chr5:151182889(+) A-I      intronic chr5:151181640(+) A-I      intronic chr5:151172390(+) A-I      intronic chr5:151166427(+) A-I      intronic chr5:151162574(+) A-I      intronic chr5:151173454(+) A-I      intronic chr5:151173464(+) A-I      intronic chr5:151158453(+) A-I      intronic chr5:151165675(+) A-I      intronic chr5:151171420(+) A-I      intronic chr5:151182873(+) A-I      intronic chr5:151172385(+) A-I      intronic chr5:151174716(+) A-I      intronic chr5:151158515(+) A-I      intronic chr5:151158083(+) A-I      intronic chr5:151171447(+) A-I      intronic chr5:151165703(+) A-I      intronic chr5:151171317(+) A-I      intronic chr5:151158217(+) A-I      intronic chr5:151181584(+) A-I      intronic chr5:151172423(+) A-I      intronic chr5:151183110(+) A-I      intronic chr5:151181639(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	G3BP1	chr5:151168037(+) A-I intron -    15342557 chr5:151168361(+) A-I intron -    15342557 chr5:151168570(+) A-I intron -    15342557 chr5:151168794(+) A-I intron -    15342557   //15258596 chr5:151168802(+) A-I intron -    15342557   //15258596 chr5:151168808(+) A-I intron -    15342557   //15258596 chr5:151169120(+) A-I intron -    15342557 chr5:151169486(+) A-I intron -    15342557 chr5:151169513(+) A-I intron -    15342557 chr5:151172188(+) A-I intron -    21960545 chr5:151158120(+) A-G intron -    22484847 chr5:151158217(+) A-G intron -    22484847 chr5:151158356(+) A-G intron -    22484847 chr5:151158453(+) A-G intron -    22484847 chr5:151158456(+) A-G intron -    22484847 chr5:151158467(+) A-G intron -    22484847 chr5:151158515(+) A-G intron -    22484847 chr5:151165703(+) A-G intron -    22484847 chr5:151165774(+) T-C intron -    22484847 chr5:151165807(+) A-G intron -    22484847 chr5:151168175(+) A-G intron -    22484847 chr5:151168570(+) A-G intron -    22484847 chr5:151168763(+) A-G intron -    22484847 chr5:151168794(+) A-G intron -    22484847 chr5:151168882(+) A-G intron -    22484847 chr5:151169481(+) A-G intron -    22484847 chr5:151172188(+) A-G intron -    22484847 chr5:151172190(+) A-G intron -    22484847 chr5:151172307(+) A-G intron -    22484847 chr5:151173454(+) A-G intron -    22484847 chr5:151173468(+) A-G intron -    22484847 chr5:151174604(+) C-T intron -    22484847 chr5:151177816(+) T-C intron -    22484847 chr5:151181476(+) A-G intron -    22484847 chr5:151181578(+) A-G intron -    22484847 chr5:151181583(+) A-G intron -    22484847 chr5:151181584(+) A-G intron -    22484847 chr5:151182231(+) A-G intron -    22484847 chr5:151182260(+) C-T intron -    22484847 chr5:151182459(+) A-G intron -    22484847 chr5:151182889(+) A-G intron -    22484847 chr5:151183184(+) A-G intron -    22484847 chr5:151183245(+) C-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	G3BP1	chr5:151151492-151151493(+) m6A 5'UTR//intron       24981863 chr5:151152000-151152001(+) m6A 5'UTR//intron       - chr5:151166138-151166139(+) m6A 5'UTR//exon//intron       - chr5:151166231-151166232(+) m6A CDS//exon       - chr5:151166251-151166252(+) m6A CDS//exon       - chr5:151166263-151166264(+) m6A CDS//exon       - chr5:151166281-151166282(+) m6A exon//intron       - chr5:151176802-151176803(+) m6A 3'UTR//CDS       26404942 chr5:151176826-151176827(+) m6A 3'UTR//CDS       26404942 chr5:151176844-151176845(+) m6A 3'UTR//CDS       26404942 chr5:151176850-151176851(+) m6A 3'UTR//CDS       26404942 chr5:151176856-151176857(+) m6A 3'UTR//CDS       26404942 chr5:151176862-151176863(+) m6A 3'UTR//CDS       26404942 chr5:151176911-151176912(+) m6A 3'UTR//CDS       26404942 chr5:151179493-151179494(+) m6A 3'UTR//CDS       24981863//22575960 chr5:151179520-151179521(+) m6A 3'UTR//CDS       24981863//22575960 chr5:151179550-151179551(+) m6A 3'UTR//CDS       24981863//22575960 chr5:151179556-151179557(+) m6A 3'UTR//CDS       24981863//22575960 chr5:151179809-151179810(+) m6A 3'UTR//CDS       24981863 chr5:151179827-151179828(+) m6A 3'UTR//CDS       24981863 chr5:151183490-151183491(+) m1A 3'UTR//CDS       26863196 chr5:151183493-151183494(+) m6A 3'UTR//CDS       24209618//25456834//22575960 chr5:151183540-151183541(+) m6A 3'UTR//CDS       24209618//25456834//24981863//22575960 chr5:151183609-151183610(+) m6A 3'UTR//CDS       24209618//25456834//24981863//22575960 chr5:151183682-151183683(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960 chr5:151183755-151183756(+) m6A 3'UTR       24284625//24209618//22575960 chr5:151183884-151183885(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr5:151183908-151183909(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr5:151183940-151183941(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr5:151184101-151184102(+) m6A 3'UTR       27773535 chr5:151184340-151184341(+) m6A 3'UTR       27773535 chr5:151190328-151190329(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	G3BP1	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: G3BP1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.