Basic Information:

  VIRBase ID:  

VHID00508056

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ARPC5:  NM_001270439     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ARPC5
miRBase Accession/Entrez ID	MIMAT0001581	10092
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	ARC16//dJ127C7.3//p16-Arc

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ARPC5	chr1:183596201-183596202(-) m6A 3'UTR//exon//intron       26404942 chr1:183596206-183596207(-) m6A 3'UTR//exon//intron       26404942 chr1:183596230-183596231(-) m6A 3'UTR//exon//intron       26404942 chr1:183596607-183596608(-) m6A 3'UTR//exon//intron       24284625//24981863//26404942//27371828//22575960//22608085 chr1:183596613-183596614(-) m6A 3'UTR//exon//intron       24284625//24981863//26404942//27371828//22575960//22608085 chr1:183596674-183596675(-) m6A CDS//exon//intron       24284625//24981863//26404942//27371828//22575960//22608085 chr1:183599692-183599693(-) m6A CDS//exon       26404942 chr1:183599770-183599771(-) m6A CDS//exon       27773536//22575960 chr1:183599823-183599824(-) m6A exon//intron       27773536//22575960 chr1:183599840-183599841(-) m6A exon//intron       27773536 chr1:183599915-183599916(-) m6A exon//intron       - chr1:183599952-183599953(-) m6A exon//intron       27773535 chr1:183599961-183599962(-) m6A exon//intron       27773535 chr1:183600079-183600080(-) m6A exon//intron       27773535 chr1:183600118-183600119(-) m6A exon//intron       27773535 chr1:183602204-183602205(-) m6A exon//intron       24209618//25456834//24981863//27371828//27773536 chr1:183602250-183602251(-) m6A CDS//exon       24209618//25456834//24981863//27371828//27773536 chr1:183602283-183602284(-) m6A CDS//exon       24209618//25456834//24981863//27371828//27773536 chr1:183602351-183602352(-) m6A exon//intron       24209618//25456834//24981863//27371828//27773536 chr1:183602401-183602402(-) m6A exon//intron       24209618//25456834//24981863//27371828//27773536 chr1:183602428-183602429(-) m6A exon//intron       25456834//27773536 chr1:183603045-183603046(-) m6A exon//intron       24209618//25456834//24981863 chr1:183603053-183603054(-) m6A exon//intron       24209618//25456834//24981863 chr1:183603087-183603088(-) m6A exon//intron       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085 chr1:183604666-183604667(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27371828//27773536//22575960//22608085 chr1:183604711-183604712(-) m1A CDS       26863196//26863410 chr1:183604729-183604730(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr1:183604783-183604784(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ARPC5	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ARPC5

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.