Basic Information:

  VIRBase ID:  

VHID00508029

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ABCC5:  NR_135125     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ABCC5
miRBase Accession/Entrez ID	MIMAT0001581	10057
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	ABC33//EST277145//MOAT-C//MOATC//MRP5//pABC11//SMRP

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ABCC5	chr3:183656179(-) A-I      intronic chr3:183697866(-) A-I      intronic chr3:183656314(-) A-I      intronic chr3:183656335(-) A-I      intronic chr3:183656336(-) A-I      intronic chr3:183657004(-) A-I      intronic chr3:183657017(-) A-I      intronic chr3:183657029(-) A-I      intronic chr3:183657038(-) A-I      intronic chr3:183657177(-) A-I      intronic chr3:183658743(-) A-I      intronic chr3:183697859(-) A-I      intronic chr3:183697858(-) A-I      intronic chr3:183641283(-) A-I      intronic chr3:183650918(-) A-I      intronic chr3:183658744(-) A-I      intronic chr3:183658830(-) A-I      intronic chr3:183659530(-) A-I      intronic chr3:183656300(-) A-I      intronic chr3:183659538(-) A-I      intronic chr3:183659554(-) A-I      intronic chr3:183697097(-) A-I      intronic chr3:183697836(-) A-I      intronic chr3:183653571(-) A-I      intronic chr3:183656172(-) A-I      intronic chr3:183659747(-) A-I      intronic chr3:183686080(-) A-I      intronic chr3:183697426(-) A-I      intronic chr3:183697857(-) A-I      intronic chr3:183697882(-) A-I      intronic chr3:183708113(-) A-I      intronic chr3:183715685(-) A-I      intronic chr3:183715750(-) A-I      intronic chr3:183715752(-) A-I      intronic chr3:183715786(-) A-I      intronic chr3:183715792(-) A-I      intronic chr3:183716795(-) A-I      intronic chr3:183718117(-) A-I      intronic chr3:183727702(-) A-I      intronic chr3:183727719(-) A-I      intronic chr3:183659629(-) A-I      intronic chr3:183697890(-) A-I      intronic chr3:183697867(-) A-I      intronic chr3:183688371(-) A-I      intronic chr3:183658185(-) A-I      intronic chr3:183647038(-) A-I      intronic chr3:183710077(-) A-I      intronic chr3:183687474(-) A-I      intronic chr3:183687237(-) A-I      intronic chr3:183658065(-) A-I      intronic chr3:183659966(-) A-I      intronic chr3:183649162(-) A-I      intronic chr3:183658811(-) A-I      intronic chr3:183657093(-) A-I      intronic chr3:183653562(-) A-I      intronic chr3:183653403(-) A-I      intronic chr3:183647109(-) A-I      intronic chr3:183653402(-) A-I      intronic chr3:183659528(-) A-I      intronic chr3:183657055(-) A-I      intronic chr3:183655021(-) A-I      intronic chr3:183660086(-) A-I      intronic chr3:183711134(-) A-I      intronic chr3:183650489(-) A-I      intronic chr3:183657145(-) A-I      intronic chr3:183696984(-) A-I      intronic chr3:183697070(-) A-I      intronic chr3:183659965(-) A-I      intronic chr3:183659605(-) A-I      intronic chr3:183696941(-) A-I      intronic chr3:183731315(-) A-I      intronic chr3:183657215(-) A-I      intronic chr3:183650799(-) A-I      intronic chr3:183644269(-) A-I      intronic chr3:183657099(-) A-I      intronic chr3:183658175(-) A-I      intronic chr3:183659516(-) A-I      intronic chr3:183697525(-) A-I      intronic chr3:183650790(-) A-I      intronic chr3:183711974(-) A-I      intronic chr3:183652037(-) A-I      intronic chr3:183658920(-) A-I      intronic chr3:183718925(-) A-I      3'UTR chr3:183697462(-) A-I      intronic chr3:183696985(-) A-I      intronic chr3:183659721(-) A-I      intronic chr3:183658118(-) A-I      intronic chr3:183652079(-) A-I      intronic chr3:183656210(-) A-I      intronic chr3:183641867(-) A-I      intronic chr3:183687236(-) A-I      intronic chr3:183657218(-) A-I      intronic chr3:183708973(-) A-I      intronic chr3:183658739(-) A-I      intronic chr3:183660020(-) A-I      intronic chr3:183646964(-) A-I      intronic chr3:183697895(-) A-I      intronic chr3:183658937(-) A-I      intronic chr3:183731166(-) A-I      intronic chr3:183641904(-) A-I      intronic chr3:183650793(-) A-I      intronic chr3:183641927(-) A-I      intronic chr3:183652075(-) A-I      intronic chr3:183653464(-) A-I      intronic chr3:183658867(-) A-I      intronic chr3:183688361(-) A-I      intronic chr3:183688398(-) A-I      intronic chr3:183649359(-) A-I      intronic chr3:183652012(-) A-I      intronic chr3:183659882(-) A-I      intronic chr3:183688311(-) A-I      intronic chr3:183659754(-) A-I      intronic chr3:183666627(-) A-I      intronic chr3:183641302(-) A-I      intronic chr3:183650555(-) A-I      intronic chr3:183658784(-) A-I      intronic chr3:183658943(-) A-I      intronic chr3:183686062(-) A-I      intronic chr3:183654908(-) A-I      intronic chr3:183658042(-) A-I      intronic chr3:183697485(-) A-I      intronic chr3:183658068(-) A-I      intronic chr3:183697513(-) A-I      intronic chr3:183653522(-) A-I      intronic chr3:183731235(-) A-I      intronic chr3:183650549(-) A-I      intronic chr3:183652580(-) A-I      intronic chr3:183656964(-) A-I      intronic chr3:183649304(-) A-I      intronic chr3:183641915(-) A-I      intronic chr3:183660111(-) A-I      intronic chr3:183657121(-) A-I      intronic chr3:183652042(-) A-I      intronic chr3:183711824(-) A-I      intronic chr3:183659498(-) A-I      intronic chr3:183697896(-) A-I      intronic chr3:183641981(-) A-I      intronic chr3:183712721(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ABCC5	chr3:183697513(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ABCC5	chr3:183643464-183643465(-) m6A 3'UTR//CDS       - chr3:183643472-183643473(-) m6A 3'UTR//CDS       - chr3:183645210-183645211(-) m6A 3'UTR//CDS       - chr3:183646551-183646552(-) m6A 3'UTR//CDS       - chr3:183646577-183646578(-) m6A 3'UTR//CDS       - chr3:183667639-183667640(-) m6A 3'UTR//CDS//intron       27773535 chr3:183677562-183677563(-) m6A 3'UTR//CDS       24981863 chr3:183677576-183677577(-) m6A 3'UTR//CDS       24981863 chr3:183677604-183677605(-) m6A 3'UTR//CDS       24981863 chr3:183683027-183683028(-) m6A 3'UTR//CDS       - chr3:183685511-183685512(-) m6A 3'UTR//CDS//exon       27371828//27773536 chr3:183685548-183685549(-) m6A 3'UTR//CDS//exon       27371828//27773536 chr3:183689382-183689383(-) m6A 3'UTR//CDS//exon       27371828//27773536 chr3:183689456-183689457(-) m6A 3'UTR//CDS//exon       25456834//24981863//27773535//27371828//27773536 chr3:183689555-183689556(-) m6A 3'UTR//CDS//exon       25456834//24981863//27773535//27371828//27773536//22608085 chr3:183689588-183689589(-) m6A 3'UTR//CDS//exon       25456834//24981863//27773535//27371828//22608085 chr3:183689612-183689613(-) m6A 3'UTR//CDS//exon       24981863//27773535//22608085 chr3:183689669-183689670(-) m6A 3'UTR//CDS       27773535 chr3:183702218-183702219(-) Y 3'UTR//intron       26075521 chr3:183702248-183702249(-) m6A 3'UTR//intron       24981863//27773535//22608085 chr3:183702305-183702306(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr3:183702335-183702336(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//22608085 chr3:183702344-183702345(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr3:183702380-183702381(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr3:183702465-183702466(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr3:183702512-183702513(-) m6A 3'UTR//intron       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr3:183702638-183702639(-) m6A 3'UTR//CDS//intron       24284625//25456834//24981863//27371828//22608085 chr3:183702668-183702669(-) m6A 3'UTR//CDS//intron       24981863//27371828//22608085 chr3:183705269-183705270(-) m6A 3'UTR//intron       25456834//24981863//22608085 chr3:183705299-183705300(-) m6A 3'UTR//intron       25456834//24981863//22608085 chr3:183705321-183705322(-) m6A 3'UTR//intron       25456834//22608085 chr3:183705354-183705355(-) m6A 3'UTR//intron       25456834//22608085 chr3:183707023-183707024(-) m6A 3'UTR//CDS       27773535 chr3:183732085-183732086(-) m6A CDS       24981863 chr3:183732110-183732111(-) m6A CDS       24981863 chr3:183732196-183732197(-) m6A 5'UTR       24981863 chr3:183732219-183732220(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ABCC5	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ABCC5

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.