Basic Information:

  VIRBase ID:  

VHID00507949

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          HS3ST3B1:  NR_130138     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	HS3ST3B1
miRBase Accession/Entrez ID	MIMAT0001581	9953
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	3-OST-3B//3OST3B1//h3-OST-3B

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HS3ST3B1	chr17:14228277(+) A-I      intronic chr17:14228290(+) A-I      intronic chr17:14228296(+) A-I      intronic chr17:14228295(+) A-I      intronic chr17:14228297(+) A-I      intronic chr17:14246373(+) A-I      intronic chr17:14247340(+) A-I      intronic chr17:14247343(+) A-I      intronic chr17:14218890(+) A-I      intronic chr17:14238805(+) A-I      intronic chr17:14230159(+) A-I      intronic chr17:14218954(+) A-I      intronic chr17:14236529(+) A-I      intronic chr17:14241816(+) A-I      intronic chr17:14217377(+) A-I      intronic chr17:14218963(+) A-I      intronic chr17:14236637(+) A-I      intronic chr17:14217376(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	HS3ST3B1	chr17:14232451(+) A-I intron -    19478186

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HS3ST3B1	chr17:14204459-14204460(+) m6A 5'UTR       24981863 chr17:14204724-14204725(+) m6A 5'UTR       25456834 chr17:14204757-14204758(+) m6A 5'UTR       25456834//24981863 chr17:14204785-14204786(+) m6A 5'UTR       25456834//24981863 chr17:14205193-14205194(+) m6A CDS       25456834//24981863 chr17:14207180-14207181(+) m6A intron       25456834//24981863//22608085 chr17:14207205-14207206(+) m6A intron       25456834//24981863//22608085 chr17:14207220-14207221(+) m6A intron       25456834//24981863//22608085 chr17:14207225-14207226(+) m6A intron       25456834//24981863//22608085 chr17:14207378-14207379(+) m6A intron       25456834//24981863//22608085 chr17:14207402-14207403(+) m6A intron       25456834//24981863//22608085 chr17:14207478-14207479(+) m6A intron       25456834//24981863//22608085 chr17:14207553-14207554(+) m6A intron       25456834//22608085 chr17:14207566-14207567(+) m6A intron       25456834//22608085 chr17:14207659-14207660(+) m6A intron       25456834//24981863//22608085 chr17:14207674-14207675(+) m6A intron       25456834//22608085 chr17:14208099-14208100(+) m6A intron       22608085 chr17:14208123-14208124(+) m6A intron       22608085 chr17:14208143-14208144(+) m6A intron       22608085 chr17:14208507-14208508(+) m6A intron       25456834//24981863//22608085 chr17:14208595-14208596(+) m6A intron       25456834//24981863//22608085 chr17:14208604-14208605(+) m6A intron       25456834//24981863//22608085 chr17:14208616-14208617(+) m6A intron       25456834//24981863//22608085 chr17:14208651-14208652(+) m6A intron       25456834//24981863//22608085 chr17:14208698-14208699(+) m6A intron       25456834//22608085 chr17:14232560-14232561(+) m6A intron       27773535 chr17:14248727-14248728(+) m6A CDS       24981863 chr17:14248757-14248758(+) m6A CDS       24981863 chr17:14248780-14248781(+) m6A CDS       24981863//22608085 chr17:14248843-14248844(+) m6A CDS       25456834//24981863//22608085 chr17:14248855-14248856(+) m6A CDS       25456834//24981863//22608085 chr17:14248967-14248968(+) m6A 3'UTR       25456834//24981863//22608085 chr17:14251468-14251469(+) m6A 3'UTR       24981863//22608085 chr17:14251521-14251522(+) m6A 3'UTR       24981863//22608085 chr17:14251558-14251559(+) m6A 3'UTR       24981863//22608085 chr17:14251564-14251565(+) m6A 3'UTR       24981863//22608085 chr17:14251605-14251606(+) m6A 3'UTR       24981863//22608085 chr17:14252305-14252306(+) m6A 3'UTR       22608085 chr17:14252364-14252365(+) m6A 3'UTR       24981863//22608085 chr17:14252371-14252372(+) m6A 3'UTR       24981863//22608085 chr17:14252443-14252444(+) m6A 3'UTR       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	HS3ST3B1	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: HS3ST3B1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.