Basic Information:

  VIRBase ID:  

VHID00507905

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          SV2A:  NM_001328675     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	SV2A
miRBase Accession/Entrez ID	MIMAT0001581	9900
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	SV2

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SV2A	chr1:149874889-149874890(-) m6A 3'UTR       27773535 chr1:149874948-149874949(-) m6A 3'UTR       27773535 chr1:149874955-149874956(-) m6A 3'UTR       27773535 chr1:149874985-149874986(-) m6A 3'UTR       27773535 chr1:149875142-149875143(-) Y 3'UTR       26075521 chr1:149875528-149875529(-) m6A 3'UTR       27773536 chr1:149875545-149875546(-) m6A 3'UTR       27773536 chr1:149884893-149884894(-) m6A CDS       24209618//25456834//24981863 chr1:149884951-149884952(-) m6A CDS       24209618//25456834//24981863//27371828//22608085 chr1:149885181-149885182(-) m6A CDS       24209618//25456834//24981863//27773535//27371828//22608085 chr1:149885288-149885289(-) m6A CDS       24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr1:149885342-149885343(-) m6A CDS       24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr1:149885372-149885373(-) m6A CDS       24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr1:149885418-149885419(-) m6A 5'UTR       24209618//25456834//24981863//27773535//27371828//27773536//22608085 chr1:149885510-149885511(-) m6A 5'UTR       24209618//25456834//24981863//27773535//27371828//22608085 chr1:149885548-149885549(-) m6A 5'UTR       24209618//25456834//24981863//27371828//22608085 chr1:149885608-149885609(-) m6A 5'UTR       24209618//24981863//27371828//22608085 chr1:149889294-149889295(-) m6A 5'UTR       24209618//24981863//27773535 chr1:149889300-149889301(-) m6A 5'UTR       24209618//24981863//27773535 chr1:149889316-149889317(-) m6A 5'UTR       24209618//24981863 chr1:149889335-149889336(-) m6A 5'UTR       24209618//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SV2A	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: SV2A

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.