Basic Information:

  VIRBase ID:  

VHID00507717

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          WSCD2:  NM_014653     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	WSCD2
miRBase Accession/Entrez ID	MIMAT0001581	9671
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	WSCD2	chr12:108568635(+) A-I      intronic chr12:108615254(+) A-I      intronic chr12:108541541(+) A-I      intronic chr12:108626046(+) A-I      intronic chr12:108634707(+) A-I      intronic chr12:108615283(+) A-I      intronic chr12:108635043(+) A-I      intronic chr12:108635251(+) A-I      intronic chr12:108635211(+) A-I      intronic chr12:108635280(+) A-I      intronic chr12:108634689(+) A-I      intronic chr12:108637034(+) A-I      intronic chr12:108615104(+) A-I      intronic chr12:108573790(+) A-I      intronic chr12:108560746(+) A-I      intronic chr12:108635265(+) A-I      intronic chr12:108635721(+) A-I      intronic chr12:108634610(+) A-I      intronic chr12:108634594(+) A-I      intronic chr12:108615213(+) A-I      intronic chr12:108615076(+) A-I      intronic chr12:108615277(+) A-I      intronic chr12:108635697(+) A-I      intronic chr12:108638428(+) A-I      intronic chr12:108634747(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	WSCD2	chr12:108589164-108589165(+) m6A 5'UTR//exon//intron       - chr12:108589229-108589230(+) m6A 5'UTR//exon//intron       25456834//24981863 chr12:108589255-108589256(+) m6A 5'UTR//exon//intron       25456834//24981863 chr12:108589291-108589292(+) m6A 5'UTR//exon//intron       25456834//24981863 chr12:108589308-108589309(+) m6A 5'UTR//exon//intron       25456834 chr12:108589328-108589329(+) m6A 5'UTR//exon//intron       25456834 chr12:108589357-108589358(+) m6A 5'UTR//exon//intron       25456834 chr12:108589444-108589445(+) m6A 5'UTR//exon//intron       25456834 chr12:108589494-108589495(+) m6A 5'UTR//intron       25456834 chr12:108589501-108589502(+) m6A 5'UTR//intron       25456834 chr12:108589538-108589539(+) m6A 5'UTR//intron       25456834 chr12:108589751-108589752(+) m6A CDS//intron       25456834 chr12:108589760-108589761(+) m6A CDS//intron       25456834 chr12:108589841-108589842(+) m6A CDS//intron       25456834 chr12:108589878-108589879(+) m6A CDS//intron       25456834 chr12:108590088-108590089(+) m6A exon//intron       25456834 chr12:108641788-108641789(+) m6A CDS       25456834 chr12:108641821-108641822(+) m6A CDS       25456834 chr12:108641866-108641867(+) m6A CDS       25456834 chr12:108641878-108641879(+) m6A CDS       25456834 chr12:108641935-108641936(+) m6A CDS       25456834 chr12:108642022-108642023(+) m6A CDS       25456834//22575960 chr12:108642033-108642034(+) m6A CDS       25456834//22575960 chr12:108642082-108642083(+) m6A CDS       25456834 chr12:108642144-108642145(+) m6A 3'UTR       25456834//22575960 chr12:108642175-108642176(+) m6A 3'UTR       25456834 chr12:108642182-108642183(+) m6A 3'UTR       25456834 chr12:108642226-108642227(+) m6A 3'UTR       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	WSCD2	Cytosol K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Membrane K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: WSCD2

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.