Basic Information:

  VIRBase ID:  

VHID00507647

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7903

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          CDC42BPB:  NM_006035     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	CDC42BPB
miRBase Accession/Entrez ID	MIMAT0001581	9578
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	MRCKB

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CDC42BPB	chr14:103427404(-) A-I      intronic chr14:103427409(-) A-I      intronic chr14:103446664(-) A-I      intronic chr14:103448167(-) A-I      intronic chr14:103427454(-) A-I      intronic chr14:103427436(-) A-I      intronic chr14:103405090(-) A-I      intronic chr14:103513482(-) A-I      intronic chr14:103513472(-) A-I      intronic chr14:103405051(-) A-I      intronic chr14:103463005(-) A-I      intronic chr14:103482142(-) A-I      intronic chr14:103403085(-) A-I      intronic chr14:103513173(-) A-I      intronic chr14:103482143(-) A-I      intronic chr14:103513170(-) A-I      intronic chr14:103482160(-) A-I      intronic chr14:103425277(-) A-I      intronic chr14:103487681(-) A-I      intronic chr14:103463004(-) A-I      intronic chr14:103487727(-) A-I      intronic chr14:103445181(-) A-I      intronic chr14:103513441(-) A-I      intronic chr14:103487740(-) A-I      intronic chr14:103513158(-) A-I      intronic chr14:103513139(-) A-I      intronic chr14:103432050(-) A-I      intronic chr14:103487751(-) A-I      intronic chr14:103508876(-) A-I      intronic chr14:103488788(-) A-I      intronic chr14:103427246(-) A-I      intronic chr14:103504309(-) A-I      intronic chr14:103504282(-) A-I      intronic chr14:103489552(-) A-I      intronic chr14:103462948(-) A-I      intronic chr14:103427460(-) A-I      intronic chr14:103425253(-) A-I      intronic chr14:103489557(-) A-I      intronic chr14:103462933(-) A-I      intronic chr14:103502767(-) A-I      intronic chr14:103462920(-) A-I      intronic chr14:103489581(-) A-I      intronic chr14:103502764(-) A-I      intronic chr14:103462906(-) A-I      intronic chr14:103502095(-) A-I      intronic chr14:103501948(-) A-I      intronic chr14:103501640(-) A-I      intronic chr14:103501621(-) A-I      intronic chr14:103501073(-) A-I      intronic chr14:103462905(-) A-I      intronic chr14:103501055(-) A-I      intronic chr14:103427380(-) A-I      intronic chr14:103501007(-) A-I      intronic chr14:103426299(-) A-I      intronic chr14:103489642(-) A-I      intronic chr14:103462509(-) A-I      intronic chr14:103462495(-) A-I      intronic chr14:103500993(-) A-I      intronic chr14:103425299(-) A-I      intronic chr14:103500592(-) A-I      intronic chr14:103499227(-) A-I      intronic chr14:103499148(-) A-I      intronic chr14:103462487(-) A-I      intronic chr14:103446686(-) A-I      intronic chr14:103446682(-) A-I      intronic chr14:103446633(-) A-I      intronic chr14:103445834(-) A-I      intronic chr14:103445781(-) A-I      intronic chr14:103445757(-) A-I      intronic chr14:103445728(-) A-I      intronic chr14:103445726(-) A-I      intronic chr14:103445722(-) A-I      intronic chr14:103445719(-) A-I      intronic chr14:103489479(-) A-I      intronic chr14:103445700(-) A-I      intronic chr14:103445125(-) A-I      intronic chr14:103445349(-) A-I      intronic chr14:103445641(-) A-I      intronic chr14:103425283(-) A-I      intronic chr14:103496133(-) A-I      intronic chr14:103445618(-) A-I      intronic chr14:103445615(-) A-I      intronic chr14:103445306(-) A-I      intronic chr14:103445297(-) A-I      intronic chr14:103495705(-) A-I      intronic chr14:103497318(-) A-I      intronic chr14:103425442(-) A-I      intronic chr14:103495742(-) A-I      intronic chr14:103496951(-) A-I      intronic chr14:103496957(-) A-I      intronic chr14:103445122(-) A-I      intronic chr14:103496964(-) A-I      intronic chr14:103499130(-) A-I      intronic chr14:103428018(-) A-I      intronic chr14:103506447(-) A-I      intronic chr14:103431370(-) A-I      intronic chr14:103426843(-) A-I      intronic chr14:103432237(-) A-I      intronic chr14:103446587(-) A-I      intronic chr14:103516214(-) A-I      intronic chr14:103496921(-) A-I      intronic chr14:103409536(-) A-I      intronic chr14:103432231(-) A-I      intronic chr14:103409535(-) A-I      intronic chr14:103445686(-) A-I      intronic chr14:103461708(-) A-I      intronic chr14:103432212(-) A-I      intronic chr14:103432211(-) A-I      intronic chr14:103500990(-) A-I      intronic chr14:103445713(-) A-I      intronic chr14:103431495(-) A-I      intronic chr14:103431438(-) A-I      intronic chr14:103445178(-) A-I      intronic chr14:103403080(-) A-I      intronic chr14:103497212(-) A-I      intronic chr14:103431435(-) A-I      intronic chr14:103463073(-) A-I      intronic chr14:103431541(-) A-I      intronic chr14:103429078(-) A-I      intronic chr14:103501111(-) A-I      intronic chr14:103428019(-) A-I      intronic chr14:103501921(-) A-I      intronic chr14:103429049(-) A-I      intronic chr14:103428073(-) A-I      intronic chr14:103412424(-) A-I      intronic chr14:103427812(-) A-I      intronic chr14:103427463(-) A-I      intronic chr14:103513473(-) A-I      intronic chr14:103461546(-) A-I      intronic chr14:103425260(-) A-I      intronic chr14:103520473(-) A-I      intronic chr14:103427395(-) A-I      intronic chr14:103463066(-) A-I      intronic chr14:103488842(-) A-I      intronic chr14:103481822(-) A-I      intronic chr14:103463113(-) A-I      intronic chr14:103521700(-) A-I      intronic chr14:103520474(-) A-I      intronic chr14:103519597(-) A-I      intronic chr14:103519482(-) A-I      intronic chr14:103519430(-) A-I      intronic chr14:103519428(-) A-I      intronic chr14:103517037(-) A-I      intronic chr14:103517032(-) A-I      intronic chr14:103516277(-) A-I      intronic chr14:103514194(-) A-I      intronic chr14:103425282(-) A-I      intronic chr14:103518372(-) A-I      intronic chr14:103461666(-) A-I      intronic chr14:103501933(-) A-I      intronic chr14:103445222(-) A-I      intronic chr14:103431442(-) A-I      intronic chr14:103516926(-) A-I      intronic chr14:103403098(-) A-I      intronic chr14:103445151(-) A-I      intronic chr14:103463097(-) A-I      intronic chr14:103445200(-) A-I      intronic chr14:103432263(-) A-I      intronic chr14:103504618(-) A-I      intronic chr14:103503769(-) A-I      intronic chr14:103499155(-) A-I      intronic chr14:103445232(-) A-I      intronic chr14:103461623(-) A-I      intronic chr14:103461588(-) A-I      intronic chr14:103503282(-) A-I      intronic chr14:103503768(-) A-I      intronic chr14:103513002(-) A-I      intronic chr14:103428117(-) A-I      intronic chr14:103454193(-) A-I      intronic chr14:103445421(-) A-I      intronic chr14:103501015(-) A-I      intronic chr14:103517025(-) A-I      intronic chr14:103516253(-) A-I      intronic chr14:103428152(-) A-I      intronic chr14:103446573(-) A-I      intronic chr14:103425658(-) A-I      intronic chr14:103493011(-) A-I      intronic chr14:103445687(-) A-I      intronic chr14:103446708(-) A-I      intronic chr14:103455975(-) A-I      intronic chr14:103517072(-) A-I      intronic chr14:103431441(-) A-I      intronic chr14:103429150(-) A-I      intronic chr14:103514097(-) A-I      intronic chr14:103506944(-) A-I      intronic chr14:103491910(-) A-I      intronic chr14:103514193(-) A-I      intronic chr14:103459440(-) A-I      intronic chr14:103432131(-) A-I      intronic chr14:103425551(-) A-I      intronic chr14:103502244(-) A-I      intronic chr14:103518379(-) A-I      intronic chr14:103513365(-) A-I      intronic chr14:103501594(-) A-I      intronic chr14:103425198(-) A-I      intronic chr14:103516175(-) A-I      intronic chr14:103482083(-) A-I      intronic chr14:103513982(-) A-I      intronic chr14:103482082(-) A-I      intronic chr14:103516188(-) A-I      intronic chr14:103496911(-) A-I      intronic chr14:103425209(-) A-I      intronic chr14:103519442(-) A-I      intronic chr14:103520316(-) A-I      intronic chr14:103488796(-) A-I      intronic chr14:103445126(-) A-I      intronic chr14:103487679(-) A-I      intronic chr14:103445187(-) A-I      intronic chr14:103501767(-) A-I      intronic chr14:103511090(-) A-I      intronic chr14:103405103(-) A-I      intronic chr14:103501477(-) A-I      intronic chr14:103511352(-) A-I      intronic chr14:103431558(-) A-I      intronic chr14:103462987(-) A-I      intronic chr14:103445742(-) A-I      intronic chr14:103520254(-) A-I      intronic chr14:103513455(-) A-I      intronic chr14:103489707(-) A-I      intronic chr14:103489705(-) A-I      intronic chr14:103476402(-) A-I      intronic chr14:103431335(-) A-I      intronic chr14:103488791(-) A-I      intronic chr14:103445308(-) A-I      intronic chr14:103462984(-) A-I      intronic chr14:103445335(-) A-I      intronic chr14:103423103(-) A-I      intronic chr14:103513545(-) A-I      intronic chr14:103445196(-) A-I      intronic chr14:103519585(-) A-I      intronic chr14:103506661(-) A-I      intronic chr14:103403343(-) A-I      intronic chr14:103517000(-) A-I      intronic chr14:103499226(-) A-I      intronic chr14:103431542(-) A-I      intronic chr14:103497291(-) A-I      intronic chr14:103519443(-) A-I      intronic chr14:103513186(-) A-I      intronic chr14:103513187(-) A-I      intronic chr14:103445358(-) A-I      intronic chr14:103448088(-) A-I      intronic chr14:103499107(-) A-I      intronic chr14:103431427(-) A-I      intronic chr14:103445822(-) A-I      intronic chr14:103445816(-) A-I      intronic chr14:103425451(-) A-I      intronic chr14:103461893(-) A-I      intronic chr14:103471039(-) A-I      intronic chr14:103425377(-) A-I      intronic chr14:103427929(-) A-I      intronic chr14:103426287(-) A-I      intronic chr14:103461644(-) A-I      intronic chr14:103508881(-) A-I      intronic chr14:103445613(-) A-I      intronic chr14:103461584(-) A-I      intronic chr14:103500671(-) A-I      intronic chr14:103409590(-) A-I      intronic chr14:103445310(-) A-I      intronic chr14:103501876(-) A-I      intronic chr14:103513477(-) A-I      intronic chr14:103503813(-) A-I      intronic chr14:103456113(-) A-I      intronic chr14:103479058(-) A-I      intronic chr14:103445743(-) A-I      intronic chr14:103425229(-) A-I      intronic chr14:103445257(-) A-I      intronic chr14:103432232(-) A-I      intronic chr14:103446747(-) A-I      intronic chr14:103496134(-) A-I      intronic chr14:103463089(-) A-I      intronic chr14:103520280(-) A-I      intronic chr14:103504178(-) A-I      intronic chr14:103461600(-) A-I      intronic chr14:103459462(-) A-I      intronic chr14:103516189(-) A-I      intronic chr14:103471042(-) A-I      intronic chr14:103477825(-) A-I      intronic chr14:103519854(-) A-I      intronic chr14:103432111(-) A-I      intronic chr14:103425259(-) A-I      intronic chr14:103464463(-) A-I      intronic chr14:103513428(-) A-I      intronic chr14:103517018(-) A-I      intronic chr14:103431355(-) A-I      intronic chr14:103501511(-) A-I      intronic chr14:103426847(-) A-I      intronic chr14:103499177(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CDC42BPB	chr14:103431335(-) A-I intron -    15342557 chr14:103431355(-) A-I intron -    15342557 chr14:103431370(-) A-I intron -    15342557 chr14:103431427(-) A-I intron -    15342557 chr14:103431441(-) A-I intron -    15342557 chr14:103431442(-) A-I intron -    15342557 chr14:103431558(-) A-I intron -    15342557 chr14:103432131(-) A-I intron -    15342557 chr14:103432153(-) A-I intron -    15342557 chr14:103432232(-) A-I intron -    15342557 chr14:103432263(-) A-I intron -    15342557 chr14:103445257(-) A-I intron -    21960545 chr14:103445686(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CDC42BPB	chr14:103398759-103398760(-) m6A 3'UTR       27773535 chr14:103398769-103398770(-) m6A 3'UTR       27773535 chr14:103399005-103399006(-) m6A 3'UTR       24284625//27773535//22575960 chr14:103399155-103399156(-) m6A 3'UTR       24284625 chr14:103399338-103399339(-) m6A 3'UTR       - chr14:103399475-103399476(-) m6A 3'UTR       - chr14:103399488-103399489(-) m6A 3'UTR       - chr14:103399577-103399578(-) m6A 3'UTR       24981863 chr14:103399635-103399636(-) m6A 3'UTR       24284625//24981863 chr14:103399646-103399647(-) m6A 3'UTR       24284625//24981863//22575960 chr14:103399685-103399686(-) m6A 3'UTR       24284625//24981863//22575960 chr14:103399695-103399696(-) m6A 3'UTR       24284625//24981863//22575960 chr14:103399726-103399727(-) m6A 3'UTR       24284625//24981863//22575960 chr14:103399806-103399807(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960 chr14:103399864-103399865(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960 chr14:103399919-103399920(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27371828 chr14:103399931-103399932(-) Gm 3'UTR       - chr14:103399987-103399988(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27371828//22575960 chr14:103400159-103400160(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960 chr14:103400169-103400170(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960 chr14:103404453-103404454(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960 chr14:103404459-103404460(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960 chr14:103404671-103404672(-) m6A CDS       24284625//24209618//24981863//27773535//22575960 chr14:103405956-103405957(-) m6A CDS       24284625//24981863//26404942//27773535 chr14:103406049-103406050(-) m6A CDS       24284625//24981863//26404942//27773535 chr14:103406180-103406181(-) m6A CDS       24284625//24981863//26404942//27773535 chr14:103406262-103406263(-) m6A CDS//exon       24284625//27773535 chr14:103406453-103406454(-) m6A CDS//exon       24284625 chr14:103406580-103406581(-) m6A CDS//exon       22575960 chr14:103406938-103406939(-) m6A exon//intron       24981863 chr14:103406943-103406944(-) m6A exon//intron       24981863 chr14:103410283-103410284(-) Am CDS//exon       - chr14:103410289-103410290(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr14:103410300-103410301(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr14:103410415-103410416(-) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr14:103410484-103410485(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr14:103410619-103410620(-) m6A CDS//exon       24284625//25456834//24981863//26404942//22575960//22608085 chr14:103410662-103410663(-) m6A CDS//exon       24284625//25456834//24981863//26404942//22575960//22608085 chr14:103410736-103410737(-) m6A CDS//exon       24284625//24981863//22575960 chr14:103410788-103410789(-) Cm CDS//exon       - chr14:103429465-103429466(-) m6A CDS       24981863 chr14:103429488-103429489(-) m6A CDS       24981863//27773536 chr14:103430949-103430950(-) m6A CDS       27773536//22575960 chr14:103432623-103432624(-) m6A CDS       27773536//22575960 chr14:103433468-103433469(-) m6A CDS       24981863//27773535 chr14:103433486-103433487(-) m6A CDS       24981863//27773535 chr14:103434617-103434618(-) m6A CDS       24981863//27773535 chr14:103436527-103436528(-) m6A CDS       24209618//27773535//27773536//22575960 chr14:103438340-103438341(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960 chr14:103438453-103438454(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960 chr14:103440425-103440426(-) m6A CDS       24209618//24981863//27773535//27371828//27773536//22575960 chr14:103440455-103440456(-) m6A CDS       24209618//24981863//27773535//27371828//22575960 chr14:103440479-103440480(-) m6A CDS       24209618//24981863//27773535//27371828//22575960 chr14:103442082-103442083(-) m6A CDS       24209618//24981863//27773535//22575960 chr14:103442128-103442129(-) m6A CDS       24981863//27773535//22575960 chr14:103442253-103442254(-) m6A CDS       24981863//22575960 chr14:103442308-103442309(-) m6A CDS       24981863 chr14:103449899-103449900(-) m6A CDS       27773535 chr14:103449918-103449919(-) m6A CDS       27773535 chr14:103523564-103523565(-) m6A 5'UTR       24209618//25456834//27773536 chr14:103523696-103523697(-) m6A 5'UTR       24209618//25456834//27773536//22575960 chr14:103523719-103523720(-) m6A 5'UTR       24209618//25456834//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CDC42BPB	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: CDC42BPB

Evidence Support:

Strong-Evidence	RISC-IP
Prediction-Evidence	miRanda//RNAHybrid
Support Database	ViRBase//VmiReg

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.