Basic Information:

  VIRBase ID:  

VHID00507633

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          VPS26A:  NM_001318945     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	VPS26A
miRBase Accession/Entrez ID	MIMAT0001581	9559
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	HB58//Hbeta58//PEP8A//VPS26

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	VPS26A	chr10:70911158(+) A-I      intronic chr10:70913082(+) A-I      intronic chr10:70911153(+) A-I      intronic chr10:70913075(+) A-I      intronic chr10:70911163(+) A-I      intronic chr10:70913066(+) A-I      intronic chr10:70913045(+) A-I      intronic chr10:70913041(+) A-I      intronic chr10:70911169(+) A-I      intronic chr10:70913040(+) A-I      intronic chr10:70914554(+) A-I      intronic chr10:70910843(+) A-I      intronic chr10:70914546(+) A-I      intronic chr10:70914541(+) A-I      intronic chr10:70913517(+) A-I      intronic chr10:70913306(+) A-I      intronic chr10:70913215(+) A-I      intronic chr10:70886203(+) A-I      intronic chr10:70913080(+) A-I      intronic chr10:70912980(+) A-I      intronic chr10:70912935(+) A-I      intronic chr10:70912931(+) A-I      intronic chr10:70912840(+) A-I      intronic chr10:70912579(+) A-I      intronic chr10:70912562(+) A-I      intronic chr10:70912538(+) A-I      intronic chr10:70912476(+) A-I      intronic chr10:70911952(+) A-I      intronic chr10:70910864(+) A-I      intronic chr10:70910859(+) A-I      intronic chr10:70910239(+) A-I      intronic chr10:70909922(+) A-I      intronic chr10:70909572(+) A-I      intronic chr10:70909564(+) A-I      intronic chr10:70908786(+) A-I      intronic chr10:70908605(+) A-I      intronic chr10:70908592(+) A-I      intronic chr10:70908543(+) A-I      intronic chr10:70907569(+) A-I      intronic chr10:70903688(+) A-I      intronic chr10:70903618(+) A-I      intronic chr10:70921080(+) A-I      intronic chr10:70903496(+) A-I      intronic chr10:70913316(+) A-I      intronic chr10:70896604(+) A-I      intronic chr10:70894571(+) A-I      intronic chr10:70893665(+) A-I      intronic chr10:70893664(+) A-I      intronic chr10:70893652(+) A-I      intronic chr10:70891023(+) A-I      intronic chr10:70889464(+) A-I      intronic chr10:70889446(+) A-I      intronic chr10:70888774(+) A-I      intronic chr10:70920838(+) A-I      intronic chr10:70919016(+) A-I      intronic chr10:70913201(+) A-I      intronic chr10:70908616(+) A-I      intronic chr10:70912471(+) A-I      intronic chr10:70912470(+) A-I      intronic chr10:70914540(+) A-I      intronic chr10:70913068(+) A-I      intronic chr10:70893657(+) A-I      intronic chr10:70909360(+) A-I      intronic chr10:70925582(+) A-I      intronic chr10:70894663(+) A-I      intronic chr10:70914832(+) A-I      intronic chr10:70913044(+) A-I      intronic chr10:70907608(+) A-I      intronic chr10:70888688(+) A-I      intronic chr10:70910012(+) A-I      intronic chr10:70925647(+) A-I      intronic chr10:70925437(+) A-I      intronic chr10:70925392(+) A-I      intronic chr10:70925361(+) A-I      intronic chr10:70923115(+) A-I      intronic chr10:70923111(+) A-I      intronic chr10:70923110(+) A-I      intronic chr10:70921922(+) A-I      intronic chr10:70919017(+) A-I      intronic chr10:70918876(+) A-I      intronic chr10:70918875(+) A-I      intronic chr10:70914602(+) A-I      intronic chr10:70912951(+) A-I      intronic chr10:70894648(+) A-I      intronic chr10:70925307(+) A-I      intronic chr10:70911822(+) A-I      intronic chr10:70912654(+) A-I      intronic chr10:70894634(+) A-I      intronic chr10:70910760(+) A-I      intronic chr10:70924918(+) A-I      intronic chr10:70914475(+) A-I      intronic chr10:70908641(+) A-I      intronic chr10:70909910(+) A-I      intronic chr10:70908719(+) A-I      intronic chr10:70925505(+) A-I      intronic chr10:70909840(+) A-I      intronic chr10:70893459(+) A-I      intronic chr10:70925476(+) A-I      intronic chr10:70925694(+) A-I      intronic chr10:70912619(+) A-I      intronic chr10:70914275(+) A-I      intronic chr10:70911861(+) A-I      intronic chr10:70914850(+) A-I      intronic chr10:70925621(+) A-I      intronic chr10:70909355(+) A-I      intronic chr10:70911885(+) A-I      intronic chr10:70911059(+) A-I      intronic chr10:70910211(+) A-I      intronic chr10:70913124(+) A-I      intronic chr10:70920949(+) A-I      intronic chr10:70887636(+) A-I      intronic chr10:70911880(+) A-I      intronic chr10:70911953(+) A-I      intronic chr10:70925591(+) A-I      intronic chr10:70912986(+) A-I      intronic chr10:70903572(+) A-I      intronic chr10:70925622(+) A-I      intronic chr10:70910844(+) A-I      intronic chr10:70911850(+) A-I      intronic chr10:70891471(+) A-I      intronic chr10:70914132(+) A-I      intronic chr10:70925362(+) A-I      intronic chr10:70912906(+) A-I      intronic chr10:70920955(+) A-I      intronic chr10:70911165(+) A-I      intronic chr10:70920839(+) A-I      intronic chr10:70914437(+) A-I      intronic chr10:70895244(+) A-I      intronic chr10:70895290(+) A-I      intronic chr10:70914137(+) A-I      intronic chr10:70888685(+) A-I      intronic chr10:70925611(+) A-I      intronic chr10:70912932(+) A-I      intronic chr10:70908764(+) A-I      intronic chr10:70888171(+) A-I      intronic chr10:70910064(+) A-I      intronic chr10:70918990(+) A-I      intronic chr10:70912945(+) A-I      intronic chr10:70929083(+) A-I      intronic chr10:70894607(+) A-I      intronic chr10:70921793(+) A-I      intronic chr10:70909351(+) A-I      intronic chr10:70908581(+) A-I      intronic chr10:70913067(+) A-I      intronic chr10:70894572(+) A-I      intronic chr10:70921890(+) A-I      intronic chr10:70893705(+) A-I      intronic chr10:70913308(+) A-I      intronic chr10:70910258(+) A-I      intronic chr10:70907742(+) A-I      intronic chr10:70910766(+) A-I      intronic chr10:70893555(+) A-I      intronic chr10:70921792(+) A-I      intronic chr10:70925432(+) A-I      intronic chr10:70911844(+) A-I      intronic chr10:70925357(+) A-I      intronic chr10:70914172(+) A-I      intronic chr10:70911845(+) A-I      intronic chr10:70913164(+) A-I      intronic chr10:70912905(+) A-I      intronic chr10:70911818(+) A-I      intronic chr10:70912547(+) A-I      intronic chr10:70925330(+) A-I      intronic chr10:70921083(+) A-I      intronic chr10:70911949(+) A-I      intronic chr10:70912989(+) A-I      intronic chr10:70913169(+) A-I      intronic chr10:70914834(+) A-I      intronic chr10:70905955(+) A-I      intronic chr10:70914772(+) A-I      intronic chr10:70894653(+) A-I      intronic chr10:70913371(+) A-I      intronic chr10:70921931(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	VPS26A	chr10:70911844(+) A-G intron -    22484847 chr10:70914132(+) A-G intron -    22484847 chr10:70914137(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	VPS26A	chr10:70883439-70883440(+) m6A 5'UTR       25456834//24981863 chr10:70883445-70883446(+) m6A 5'UTR       25456834//24981863 chr10:70883467-70883468(+) m6A 5'UTR       25456834//24981863 chr10:70883575-70883576(+) m6A 5'UTR       25456834//24981863 chr10:70883639-70883640(+) m6A 5'UTR       25456834 chr10:70883655-70883656(+) m6A 5'UTR       25456834 chr10:70883678-70883679(+) m6A 5'UTR       25456834 chr10:70883685-70883686(+) m6A 5'UTR       25456834 chr10:70883730-70883731(+) m6A 5'UTR       - chr10:70892716-70892717(+) m6A 5'UTR//CDS//exon//intron       24209618//24981863//27773535 chr10:70892740-70892741(+) m6A CDS//exon//intron       24209618//24981863//27773535 chr10:70892763-70892764(+) m6A CDS//exon//intron       27773535 chr10:70893301-70893302(+) m6A intron       27773535 chr10:70925817-70925818(+) m6A 3'UTR//CDS//exon       24981863 chr10:70925823-70925824(+) m6A 3'UTR//CDS//exon       24981863 chr10:70928310-70928311(+) m6A CDS//exon//intron       24981863 chr10:70928364-70928365(+) m6A CDS//exon//intron       24981863//26404942//27773535 chr10:70928380-70928381(+) m6A CDS//exon//intron       24981863//27773535 chr10:70929800-70929801(+) m6A exon//intron       24981863//27773535 chr10:70929879-70929880(+) m6A exon//intron       27773535//22608085 chr10:70929893-70929894(+) m6A exon//intron       22608085 chr10:70930943-70930944(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085 chr10:70930952-70930953(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085 chr10:70930959-70930960(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085 chr10:70931009-70931010(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085 chr10:70931025-70931026(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr10:70931030-70931031(+) m6A 3'UTR//exon       24284625//24981863//27773535//22608085 chr10:70931056-70931057(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr10:70931130-70931131(+) m6A 3'UTR       22608085 chr10:70932550-70932551(+) m6A 3'UTR       27773535 chr10:70932610-70932611(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	VPS26A	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: VPS26A

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.