Basic Information:

  VIRBase ID:  

VHID00507610

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          BAG4:  NM_001204878     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	BAG4
miRBase Accession/Entrez ID	MIMAT0001581	9530
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	BAG-4//SODD

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	BAG4	chr8:38048553(+) A-I      intronic chr8:38047485(+) A-I      intronic chr8:38047461(+) A-I      intronic chr8:38046546(+) A-I      intronic chr8:38043324(+) A-I      intronic chr8:38042487(+) A-I      intronic chr8:38042454(+) A-I      intronic chr8:38042453(+) A-I      intronic chr8:38042451(+) A-I      intronic chr8:38042442(+) A-I      intronic chr8:38040845(+) A-I      intronic chr8:38039210(+) A-I      intronic chr8:38039108(+) A-I      intronic chr8:38037996(+) A-I      intronic chr8:38037865(+) A-I      intronic chr8:38037855(+) A-I      intronic chr8:38037786(+) A-I      intronic chr8:38037164(+) A-I      intronic chr8:38037163(+) A-I      intronic chr8:38037902(+) A-I      intronic chr8:38036752(+) A-I      intronic chr8:38035830(+) A-I      intronic chr8:38051229(+) A-I      intronic chr8:38063825(+) A-I      intronic chr8:38063586(+) A-I      intronic chr8:38062815(+) A-I      intronic chr8:38062788(+) A-I      intronic chr8:38062642(+) A-I      intronic chr8:38061237(+) A-I      intronic chr8:38060977(+) A-I      intronic chr8:38060196(+) A-I      intronic chr8:38057617(+) A-I      intronic chr8:38056156(+) A-I      intronic chr8:38056146(+) A-I      intronic chr8:38056136(+) A-I      intronic chr8:38055782(+) A-I      intronic chr8:38055771(+) A-I      intronic chr8:38055347(+) A-I      intronic chr8:38055330(+) A-I      intronic chr8:38055318(+) A-I      intronic chr8:38055249(+) A-I      intronic chr8:38054582(+) A-I      intronic chr8:38054474(+) A-I      intronic chr8:38054433(+) A-I      intronic chr8:38054430(+) A-I      intronic chr8:38054419(+) A-I      intronic chr8:38054370(+) A-I      intronic chr8:38054361(+) A-I      intronic chr8:38052773(+) A-I      intronic chr8:38051993(+) A-I      intronic chr8:38051517(+) A-I      intronic chr8:38051516(+) A-I      intronic chr8:38051225(+) A-I      intronic chr8:38051145(+) A-I      intronic chr8:38049021(+) A-I      intronic chr8:38049013(+) A-I      intronic chr8:38069772(+) A-I      3'UTR chr8:38069773(+) A-I      3'UTR chr8:38069806(+) A-I      3'UTR chr8:38069775(+) A-I      3'UTR chr8:38050900(+) A-I      intronic chr8:38039273(+) A-I      intronic chr8:38049039(+) A-I      intronic chr8:38061939(+) A-I      intronic chr8:38062666(+) A-I      intronic chr8:38038539(+) A-I      intronic chr8:38038853(+) A-I      intronic chr8:38037239(+) A-I      intronic chr8:38055357(+) A-I      intronic chr8:38050843(+) A-I      intronic chr8:38037920(+) A-I      intronic chr8:38043272(+) A-I      intronic chr8:38036842(+) A-I      intronic chr8:38051357(+) A-I      intronic chr8:38052919(+) A-I      intronic chr8:38046554(+) A-I      intronic chr8:38064867(+) A-I      intronic chr8:38052940(+) A-I      intronic chr8:38049022(+) A-I      intronic chr8:38039400(+) A-I      intronic chr8:38037894(+) A-I      intronic chr8:38051213(+) A-I      intronic chr8:38061238(+) A-I      intronic chr8:38054534(+) A-I      intronic chr8:38054475(+) A-I      intronic chr8:38060328(+) A-I      intronic chr8:38056188(+) A-I      intronic chr8:38046429(+) A-I      intronic chr8:38049091(+) A-I      intronic chr8:38059068(+) A-I      intronic chr8:38052877(+) A-I      intronic chr8:38060036(+) A-I      intronic chr8:38058910(+) A-I      intronic chr8:38043127(+) A-I      intronic chr8:38052834(+) A-I      intronic chr8:38038869(+) A-I      intronic chr8:38051184(+) A-I      intronic chr8:38057655(+) A-I      intronic chr8:38045277(+) A-I      intronic chr8:38049095(+) A-I      intronic chr8:38037947(+) A-I      intronic chr8:38036855(+) A-I      intronic chr8:38052882(+) A-I      intronic chr8:38048089(+) A-I      intronic chr8:38052035(+) A-I      intronic chr8:38061965(+) A-I      intronic chr8:38046653(+) A-I      intronic chr8:38047510(+) A-I      intronic chr8:38051107(+) A-I      intronic chr8:38050026(+) A-I      intronic chr8:38037881(+) A-I      intronic chr8:38037898(+) A-I      intronic chr8:38042486(+) A-I      intronic chr8:38039302(+) A-I      intronic chr8:38039350(+) A-I      intronic chr8:38043182(+) A-I      intronic chr8:38054050(+) A-I      intronic chr8:38061232(+) A-I      intronic chr8:38036858(+) A-I      intronic chr8:38041999(+) A-I      intronic chr8:38060043(+) A-I      intronic chr8:38038666(+) A-I      intronic chr8:38046576(+) A-I      intronic chr8:38046405(+) A-I      intronic chr8:38064654(+) A-I      intronic chr8:38061273(+) A-I      intronic chr8:38037950(+) A-I      intronic chr8:38046308(+) A-I      intronic chr8:38046575(+) A-I      intronic chr8:38050826(+) A-I      intronic chr8:38052861(+) A-I      intronic chr8:38035806(+) A-I      intronic chr8:38049101(+) A-I      intronic chr8:38036778(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	BAG4	chr8:38035796(+) T-C intron -    22484847 chr8:38035806(+) A-G intron -    22484847 chr8:38036742(+) A-G intron -    22484847 chr8:38036747(+) A-G intron -    22484847 chr8:38038539(+) A-G intron -    22484847 chr8:38038666(+) A-G intron -    22484847 chr8:38043272(+) A-G intron -    22484847 chr8:38046405(+) A-G intron -    22484847 chr8:38046429(+) A-G intron -    22484847 chr8:38046575(+) A-G intron -    22484847 chr8:38046576(+) A-G intron -    22484847 chr8:38047510(+) A-G intron -    22484847 chr8:38050892(+) A-G intron -    22484847 chr8:38050900(+) A-G intron -    22484847 chr8:38052035(+) A-G intron -    22484847 chr8:38052919(+) A-G intron -    22484847 chr8:38054475(+) A-G intron -    22484847 chr8:38055357(+) A-G intron -    22484847 chr8:38055781(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	BAG4	chr8:38034117-38034118(+) m6A 5'UTR//intron       24981863 chr8:38034163-38034164(+) m6A 5'UTR//intron       24981863 chr8:38034197-38034198(+) m6A 5'UTR//intron       24981863 chr8:38066792-38066793(+) m6A CDS//intron       24284625//24981863//22608085 chr8:38066832-38066833(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr8:38066880-38066881(+) m6A 3'UTR//intron       24284625//22608085 chr8:38067565-38067566(+) m6A CDS       24284625//24981863//22608085 chr8:38067612-38067613(+) m6A CDS       24284625//24981863//22608085 chr8:38067619-38067620(+) m6A CDS       24284625//24981863//22608085 chr8:38067818-38067819(+) m6A CDS       24284625//24209618//24981863//27773535//22575960//22608085 chr8:38067849-38067850(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:38067893-38067894(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:38067902-38067903(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:38067918-38067919(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:38067931-38067932(+) m6A CDS       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:38068022-38068023(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:38068057-38068058(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr8:38068150-38068151(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085 chr8:38068223-38068224(+) m6A 3'UTR       24284625//24209618//24981863//27773535//22608085 chr8:38068252-38068253(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr8:38068311-38068312(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr8:38068340-38068341(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr8:38068354-38068355(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr8:38068371-38068372(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr8:38068394-38068395(+) m6A 3'UTR       24284625//24981863//27773535//22608085 chr8:38068470-38068471(+) m6A 3'UTR       24981863//22608085 chr8:38068486-38068487(+) m6A 3'UTR       24981863//22608085 chr8:38068586-38068587(+) m6A 3'UTR       27773535 chr8:38070589-38070590(+) m6A 3'UTR       27773535 chr8:38070623-38070624(+) m6A 3'UTR       27773535 chr8:38070692-38070693(+) m6A 3'UTR       24981863//27773535 chr8:38070728-38070729(+) m6A 3'UTR       24981863//27773535 chr8:38070813-38070814(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	BAG4	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: BAG4

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.