Basic Information:

  VIRBase ID:  

VHID00507567

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ROCK2:  NM_001321643     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ROCK2
miRBase Accession/Entrez ID	MIMAT0001581	9475
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	ROCK-II

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	ROCK2	chr2:11411360(-) A-I      intronic chr2:11321978(-) A-I      3'UTR chr2:11321960(-) A-I      3'UTR chr2:11321958(-) A-I      3'UTR chr2:11425915(-) A-I      intronic chr2:11425871(-) A-I      intronic chr2:11321941(-) A-I      3'UTR chr2:11328347(-) A-I      intronic chr2:11328342(-) A-I      intronic chr2:11411306(-) A-I      intronic chr2:11411333(-) A-I      intronic chr2:11411331(-) A-I      intronic chr2:11411364(-) A-I      intronic chr2:11411363(-) A-I      intronic chr2:11411326(-) A-I      intronic chr2:11434095(-) A-I      intronic chr2:11409522(-) A-I      intronic chr2:11411324(-) A-I      intronic chr2:11411355(-) A-I      intronic chr2:11411321(-) A-I      intronic chr2:11411354(-) A-I      intronic chr2:11411353(-) A-I      intronic chr2:11411348(-) A-I      intronic chr2:11411347(-) A-I      intronic chr2:11411343(-) A-I      intronic chr2:11411334(-) A-I      intronic chr2:11321975(-) A-I      3'UTR chr2:11411372(-) A-I      intronic chr2:11478253(-) A-I      intronic chr2:11425697(-) A-I      intronic chr2:11425773(-) A-I      intronic chr2:11425805(-) A-I      intronic chr2:11425319(-) A-I      intronic chr2:11425302(-) A-I      intronic chr2:11425226(-) A-I      intronic chr2:11425223(-) A-I      intronic chr2:11422329(-) A-I      intronic chr2:11422314(-) A-I      intronic chr2:11434161(-) A-I      intronic chr2:11435022(-) A-I      intronic chr2:11435078(-) A-I      intronic chr2:11435081(-) A-I      intronic chr2:11435090(-) A-I      intronic chr2:11422310(-) A-I      intronic chr2:11422202(-) A-I      intronic chr2:11435204(-) A-I      intronic chr2:11408045(-) A-I      intronic chr2:11409421(-) A-I      intronic chr2:11409446(-) A-I      intronic chr2:11409455(-) A-I      intronic chr2:11409906(-) A-I      intronic chr2:11409982(-) A-I      intronic chr2:11415226(-) A-I      intronic chr2:11415937(-) A-I      intronic chr2:11418876(-) A-I      intronic chr2:11418845(-) A-I      intronic chr2:11418831(-) A-I      intronic chr2:11418824(-) A-I      intronic chr2:11418807(-) A-I      intronic chr2:11435880(-) A-I      intronic chr2:11389294(-) A-I      intronic chr2:11388079(-) A-I      intronic chr2:11384614(-) A-I      intronic chr2:11378959(-) A-I      intronic chr2:11372352(-) A-I      intronic chr2:11360554(-) A-I      intronic chr2:11346063(-) A-I      intronic chr2:11360475(-) A-I      intronic chr2:11360448(-) A-I      intronic chr2:11360181(-) A-I      intronic chr2:11359513(-) A-I      intronic chr2:11359443(-) A-I      intronic chr2:11359421(-) A-I      intronic chr2:11352206(-) A-I      intronic chr2:11352193(-) A-I      intronic chr2:11352062(-) A-I      intronic chr2:11346086(-) A-I      intronic chr2:11346072(-) A-I      intronic chr2:11478064(-) A-I      intronic chr2:11441865(-) A-I      intronic chr2:11329985(-) A-I      intronic chr2:11328882(-) A-I      intronic chr2:11467968(-) A-I      intronic chr2:11325692(-) A-I      intronic chr2:11325772(-) A-I      intronic chr2:11360250(-) A-I      intronic chr2:11328812(-) A-I      intronic chr2:11328861(-) A-I      intronic chr2:11328855(-) A-I      intronic chr2:11328846(-) A-I      intronic chr2:11476487(-) A-I      intronic chr2:11477826(-) A-I      intronic chr2:11477927(-) A-I      intronic chr2:11328373(-) A-I      intronic chr2:11425876(-) A-I      intronic chr2:11328515(-) A-I      intronic chr2:11328509(-) A-I      intronic chr2:11328429(-) A-I      intronic chr2:11476508(-) A-I      intronic chr2:11330077(-) A-I      intronic chr2:11464433(-) A-I      intronic chr2:11328487(-) A-I      intronic chr2:11328400(-) A-I      intronic chr2:11389186(-) A-I      intronic chr2:11328482(-) A-I      intronic chr2:11359389(-) A-I      intronic chr2:11329925(-) A-I      intronic chr2:11418967(-) A-I      intronic chr2:11407936(-) A-I      intronic chr2:11345991(-) A-I      intronic chr2:11422355(-) A-I      intronic chr2:11328309(-) A-I      intronic chr2:11425796(-) A-I      intronic chr2:11330023(-) A-I      intronic chr2:11425947(-) A-I      intronic chr2:11329141(-) A-I      intronic chr2:11359829(-) A-I      intronic chr2:11415963(-) A-I      intronic chr2:11328374(-) A-I      intronic chr2:11418963(-) A-I      intronic chr2:11330045(-) A-I      intronic chr2:11412952(-) A-I      intronic chr2:11329040(-) A-I      intronic chr2:11328449(-) A-I      intronic chr2:11328297(-) A-I      intronic chr2:11328455(-) A-I      intronic chr2:11360281(-) A-I      intronic chr2:11360343(-) A-I      intronic chr2:11419031(-) A-I      intronic chr2:11410159(-) A-I      intronic chr2:11412755(-) A-I      intronic chr2:11328437(-) A-I      intronic chr2:11419012(-) A-I      intronic chr2:11478413(-) A-I      intronic chr2:11328304(-) A-I      intronic chr2:11442127(-) A-I      intronic chr2:11329079(-) A-I      intronic chr2:11321776(-) A-I      3'UTR chr2:11325795(-) A-I      intronic chr2:11425870(-) A-I      intronic chr2:11423136(-) A-I      intronic chr2:11442140(-) A-I      intronic chr2:11330115(-) A-I      intronic chr2:11360075(-) A-I      intronic chr2:11360272(-) A-I      intronic chr2:11461593(-) A-I      intronic chr2:11360213(-) A-I      intronic chr2:11425810(-) A-I      intronic chr2:11442544(-) A-I      intronic chr2:11387985(-) A-I      intronic chr2:11412874(-) A-I      intronic chr2:11410079(-) A-I      intronic chr2:11388723(-) A-I      intronic chr2:11388752(-) A-I      intronic chr2:11467827(-) A-I      intronic chr2:11442069(-) A-I      intronic chr2:11389227(-) A-I      intronic chr2:11477972(-) A-I      intronic chr2:11415999(-) A-I      intronic chr2:11325650(-) A-I      intronic chr2:11329093(-) A-I      intronic chr2:11418916(-) A-I      intronic chr2:11345987(-) A-I      intronic chr2:11412814(-) A-I      intronic chr2:11373283(-) A-I      intronic chr2:11352218(-) A-I      intronic chr2:11388687(-) A-I      intronic chr2:11329857(-) A-I      intronic chr2:11478466(-) A-I      intronic chr2:11442070(-) A-I      intronic chr2:11442169(-) A-I      intronic chr2:11359515(-) A-I      intronic chr2:11329941(-) A-I      intronic chr2:11435187(-) A-I      intronic chr2:11325651(-) A-I      intronic chr2:11477924(-) A-I      intronic chr2:11418922(-) A-I      intronic chr2:11425853(-) A-I      intronic chr2:11388599(-) A-I      intronic chr2:11329080(-) A-I      intronic chr2:11346194(-) A-I      intronic chr2:11435052(-) A-I      intronic chr2:11352322(-) A-I      intronic chr2:11477870(-) A-I      intronic chr2:11384802(-) A-I      intronic chr2:11425791(-) A-I      intronic chr2:11425770(-) A-I      intronic chr2:11477247(-) A-I      intronic chr2:11442572(-) A-I      intronic chr2:11329086(-) A-I      intronic chr2:11330082(-) A-I      intronic chr2:11372486(-) A-I      intronic chr2:11325874(-) A-I      intronic chr2:11360362(-) A-I      intronic chr2:11476620(-) A-I      intronic chr2:11477892(-) A-I      intronic chr2:11425349(-) A-I      intronic chr2:11342903(-) A-I      intronic chr2:11389197(-) A-I      intronic chr2:11412788(-) A-I      intronic chr2:11410015(-) A-I      intronic chr2:11329149(-) A-I      intronic chr2:11478267(-) A-I      intronic chr2:11360249(-) A-I      intronic chr2:11328279(-) A-I      intronic chr2:11415217(-) A-I      intronic chr2:11328888(-) A-I      intronic chr2:11434028(-) A-I      intronic chr2:11330018(-) A-I      intronic chr2:11329137(-) A-I      intronic chr2:11435068(-) A-I      intronic chr2:11329062(-) A-I      intronic chr2:11388713(-) A-I      intronic chr2:11442562(-) A-I      intronic chr2:11415261(-) A-I      intronic chr2:11467888(-) A-I      intronic chr2:11425694(-) A-I      intronic chr2:11425877(-) A-I      intronic chr2:11389176(-) A-I      intronic chr2:11447708(-) A-I      intronic chr2:11388065(-) A-I      intronic chr2:11409580(-) A-I      intronic chr2:11384800(-) A-I      intronic chr2:11335916(-) A-I      intronic chr2:11477249(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	ROCK2	chr2:11323239(-) A-I exon 3'UTR    19478186 chr2:11397668(-) A-I intron -    22327324 chr2:11328279(-) A-I intron -    22028664 chr2:11328297(-) A-I intron -    22028664 chr2:11328304(-) A-I intron -    22028664 chr2:11328309(-) A-I intron -    22028664 chr2:11328310(-) A-I intron -    22028664 chr2:11328373(-) A-I intron -    22028664 chr2:11328374(-) A-I intron -    22028664 chr2:11328400(-) A-I intron -    22028664 chr2:11328429(-) A-I intron -    22028664 chr2:11328437(-) A-I intron -    22028664 chr2:11328449(-) A-I intron -    22028664 chr2:11328455(-) A-I intron -    22028664 chr2:11328482(-) A-I intron -    22028664 chr2:11328487(-) A-I intron -    22028664 chr2:11328509(-) A-I intron -    22028664 chr2:11328515(-) A-I intron -    22028664 chr2:11329086(-) A-G intron -    22484847 chr2:11329137(-) A-G intron -    22484847 chr2:11329925(-) A-G intron -    22484847 chr2:11329991(-) A-G intron -    22484847 chr2:11329995(-) A-G intron -    22484847 chr2:11330071(-) A-G intron -    22484847 chr2:11330107(-) A-G intron -    22484847 chr2:11330115(-) A-G intron -    22484847 chr2:11359389(-) A-G intron -    22484847 chr2:11389159(-) A-G intron -    22484847 chr2:11389176(-) A-G intron -    22484847 chr2:11389186(-) A-G intron -    22484847 chr2:11389197(-) A-G intron -    22484847 chr2:11389227(-) A-G intron -    22484847 chr2:11412755(-) A-G intron -    22484847 chr2:11412788(-) A-G intron -    22484847 chr2:11415217(-) A-G intron -    22484847 chr2:11415261(-) A-G intron -    22484847 chr2:11418963(-) A-G intron -    22484847 chr2:11418967(-) A-G intron -    22484847 chr2:11425266(-) A-G intron -    22484847 chr2:11425349(-) A-G intron -    22484847 chr2:11442069(-) A-G intron -    22484847 chr2:11442070(-) A-G intron -    22484847 chr2:11442127(-) A-G intron -    22484847 chr2:11442140(-) A-G intron -    22484847 chr2:11442544(-) A-G intron -    22484847 chr2:11442562(-) A-G intron -    22484847 chr2:11447708(-) A-G intron -    22484847 chr2:11477247(-) A-G intron -    22484847 chr2:11477924(-) A-G intron -    22484847 chr2:11478267(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ROCK2	chr2:11319898-11319899(-) m6A 3'UTR       27773535 chr2:11320056-11320057(-) m6A 3'UTR       24284625//27773535 chr2:11320163-11320164(-) m6A 3'UTR       24284625 chr2:11320185-11320186(-) m6A 3'UTR       24284625 chr2:11320315-11320316(-) m6A 3'UTR       24284625//24981863//22575960//22608085 chr2:11320337-11320338(-) m6A 3'UTR       24284625//24981863//22575960//22608085 chr2:11320343-11320344(-) m6A 3'UTR       24284625//24981863//22575960//22608085 chr2:11320434-11320435(-) m6A 3'UTR       24284625//24981863 chr2:11321297-11321298(-) m6A 3'UTR       27773535 chr2:11323047-11323048(-) m6A 3'UTR       26404942//27773535 chr2:11323106-11323107(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085 chr2:11323236-11323237(-) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr2:11323315-11323316(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//27371828//22575960//22608085 chr2:11323341-11323342(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr2:11323363-11323364(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr2:11323451-11323452(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr2:11323502-11323503(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr2:11323507-11323508(-) m6A 3'UTR       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr2:11332278-11332279(-) m6A CDS       24284625//24209618//24981863//27773535//22575960 chr2:11332282-11332283(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085 chr2:11332321-11332322(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085 chr2:11332343-11332344(-) m6A CDS       24284625//24209618//26404942//27773535 chr2:11332369-11332370(-) m6A CDS       24284625//27773535 chr2:11332745-11332746(-) m6A CDS       26404942 chr2:11332802-11332803(-) m6A CDS//exon       24981863//26404942//27773535 chr2:11333951-11333952(-) m6A CDS//exon       24981863//27773535//22575960 chr2:11334413-11334414(-) m6A CDS//exon       26404942 chr2:11334425-11334426(-) m6A CDS//exon       26404942 chr2:11335111-11335112(-) m6A CDS//exon       26404942 chr2:11337415-11337416(-) m6A CDS       24981863//26404942//27773535 chr2:11337424-11337425(-) m6A CDS       24981863//26404942//27773535//22575960 chr2:11337441-11337442(-) m6A CDS       24981863//26404942//27773535//22575960 chr2:11337669-11337670(-) m6A CDS       24981863//26404942//27773535//22575960 chr2:11337792-11337793(-) m6A CDS       24981863//27773535//22575960 chr2:11338621-11338622(-) m6A CDS       24981863//27773535//22575960 chr2:11338630-11338631(-) m6A CDS       24981863//27773535//22575960 chr2:11338881-11338882(-) m6A CDS       24981863//27773535//22575960 chr2:11338890-11338891(-) m6A CDS       24981863//27773535//22575960 chr2:11341112-11341113(-) m6A CDS       24981863//27773535//22575960 chr2:11341118-11341119(-) m6A CDS       24981863//27773535//22575960 chr2:11341124-11341125(-) m6A CDS       24981863//27773535//22575960 chr2:11341165-11341166(-) Am CDS       - chr2:11341190-11341191(-) m6A CDS       24981863//27773535 chr2:11341266-11341267(-) m6A CDS       24981863//27773535 chr2:11341455-11341456(-) m6A CDS       24981863//27773535 chr2:11341482-11341483(-) m6A CDS       24981863//27773535//22575960 chr2:11341487-11341488(-) m6A CDS       24981863//27773535//22575960 chr2:11341526-11341527(-) m6A CDS       24981863//27773535//22575960 chr2:11342189-11342190(-) m6A CDS       24981863//27773535//22575960 chr2:11347859-11347860(-) m6A CDS       24981863//27773535//22575960 chr2:11347871-11347872(-) m6A CDS       24981863//27773535//22575960 chr2:11347881-11347882(-) m6A CDS       24981863//27773535//22575960 chr2:11347960-11347961(-) m6A CDS       24981863//27773535//22608085 chr2:11348002-11348003(-) m6A CDS       24981863//27773535//22608085 chr2:11348028-11348029(-) m6A CDS       24284625//24981863//27773535//22608085 chr2:11348436-11348437(-) m6A CDS       24284625//24981863//27773535//22608085 chr2:11348469-11348470(-) m6A CDS       24284625//24981863//27773535//22608085 chr2:11348482-11348483(-) m6A CDS       24284625//24981863//27773535//22608085 chr2:11348521-11348522(-) m6A CDS       24284625//24981863//27773535//22608085 chr2:11348535-11348536(-) m6A CDS       24284625//24981863//27773535//22608085 chr2:11348543-11348544(-) m6A CDS       24284625//24981863//27773535//22608085 chr2:11351888-11351889(-) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr2:11351903-11351904(-) m6A CDS       24284625//24981863//27773535//22575960//22608085 chr2:11354515-11354516(-) m6A 5'UTR//CDS       24981863//27773535//22575960//22608085 chr2:11354527-11354528(-) m6A 5'UTR//CDS       24981863//27773535//22575960//22608085 chr2:11354998-11354999(-) m6A 5'UTR//CDS       24981863//27773535 chr2:11355056-11355057(-) m6A 5'UTR//CDS       24981863//27773535 chr2:11355070-11355071(-) m6A 5'UTR//CDS       24981863//27773535 chr2:11355084-11355085(-) m6A 5'UTR//CDS       24981863//27773535 chr2:11355131-11355132(-) m6A 5'UTR//CDS       24981863 chr2:11355151-11355152(-) m6A 5'UTR//CDS       24981863 chr2:11355184-11355185(-) m6A 5'UTR//CDS       24981863 chr2:11355202-11355203(-) m6A 5'UTR//CDS       24981863 chr2:11355449-11355450(-) m6A 5'UTR//CDS       24981863 chr2:11355489-11355490(-) m6A 3'UTR//5'UTR//CDS       24981863 chr2:11355661-11355662(-) m6A 3'UTR//5'UTR//CDS       24981863 chr2:11355735-11355736(-) m6A 3'UTR//5'UTR//CDS       24981863//22575960 chr2:11356306-11356307(-) m6A 3'UTR//5'UTR//CDS       24981863//22575960 chr2:11357226-11357227(-) m6A 3'UTR//5'UTR//CDS       24981863//22575960 chr2:11357232-11357233(-) m6A 3'UTR//5'UTR//CDS       24981863//22575960 chr2:11357265-11357266(-) m6A 3'UTR//5'UTR//CDS       24981863//22575960 chr2:11357283-11357284(-) m6A 3'UTR//5'UTR//CDS       24981863//22575960 chr2:11367490-11367491(-) m6A 5'UTR//CDS       22575960 chr2:11484155-11484156(-) m6A 5'UTR//CDS//intron       27773536 chr2:11484216-11484217(-) m6A 5'UTR//CDS//intron       24209618//27371828//27773536 chr2:11484304-11484305(-) m6A 5'UTR//intron       24284625//24209618//27371828//27773536//22575960 chr2:11484399-11484400(-) m6A 5'UTR//intron       24284625//24209618//27371828//27773536//22575960 chr2:11484411-11484412(-) m6A 5'UTR//intron       24284625//24209618//27371828//27773536//22575960 chr2:11484536-11484537(-) m6A 5'UTR//intron       24209618//24981863//27371828//27773536//22575960//22608085 chr2:11484544-11484545(-) m6A 5'UTR//intron       24209618//24981863//27371828//27773536//22575960//22608085 chr2:11484567-11484568(-) m6A 5'UTR//intron       24209618//24981863//27371828//27773536//22575960//22608085 chr2:11488322-11488323(-) m6A exon       24209618//24981863//27371828//27773536//22575960 chr2:11488340-11488341(-) m6A exon       24209618//24981863//22575960

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ROCK2	Chromatin HCC cell line (HepG2)|K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Insoluble cytoplasm HCC cell line (HepG2)     - Membrane HCC cell line (HepG2)|K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ROCK2

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.