Detail Information

Basic Information:


  VIRBase ID:  

VHID00507417

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7903

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           STK17B:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p STK17B
miRBase
Accession/Entrez ID		 MIMAT0001581 9262
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - DRAK2

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR STK17B
chr2:197017773(-) A-I      intronic
chr2:197006911(-) A-I      intronic
chr2:197012678(-) A-I      intronic
chr2:197012672(-) A-I      intronic
chr2:197011181(-) A-I      intronic
chr2:197023546(-) A-I      intronic
chr2:197021767(-) A-I      intronic
chr2:197021706(-) A-I      intronic
chr2:197006167(-) A-I      intronic
chr2:197028655(-) A-I      intronic
chr2:197028527(-) A-I      intronic
chr2:197027514(-) A-I      intronic
chr2:197011084(-) A-I      intronic
chr2:197006894(-) A-I      intronic
chr2:197007013(-) A-I      intronic
chr2:197006952(-) A-I      intronic
chr2:197027505(-) A-I      intronic
chr2:197027492(-) A-I      intronic
chr2:197011111(-) A-I      intronic
chr2:197026445(-) A-I      intronic
chr2:197026443(-) A-I      intronic
chr2:197011171(-) A-I      intronic
chr2:197006880(-) A-I      intronic
chr2:197027482(-) A-I      intronic
chr2:197012552(-) A-I      intronic
chr2:197012561(-) A-I      intronic
chr2:197026415(-) A-I      intronic
chr2:197011165(-) A-I      intronic
chr2:197024149(-) A-I      intronic
chr2:197012548(-) A-I      intronic
chr2:197023658(-) A-I      intronic
chr2:197026424(-) A-I      intronic
chr2:197026418(-) A-I      intronic
chr2:197012623(-) A-I      intronic
chr2:197012636(-) A-I      intronic
chr2:197023587(-) A-I      intronic
chr2:197006220(-) A-I      intronic
chr2:197016832(-) A-I      intronic
chr2:197016833(-) A-I      intronic
chr2:197016999(-) A-I      intronic
chr2:197021751(-) A-I      intronic
chr2:197012657(-) A-I      intronic
chr2:197017759(-) A-I      intronic
chr2:197017781(-) A-I      intronic
chr2:197017798(-) A-I      intronic
chr2:197018779(-) A-I      intronic
chr2:197018796(-) A-I      intronic
chr2:197017752(-) A-I      intronic
chr2:197016916(-) A-I      intronic
chr2:197011100(-) A-I      intronic
chr2:197012600(-) A-I      intronic
chr2:197018906(-) A-I      intronic
chr2:197014026(-) A-I      intronic
chr2:197007055(-) A-I      intronic
chr2:197017002(-) A-I      intronic
chr2:197024282(-) A-I      intronic
chr2:197011051(-) A-I      intronic
chr2:197024235(-) A-I      intronic
chr2:197017680(-) A-I      intronic
chr2:197017000(-) A-I      intronic
chr2:197018846(-) A-I      intronic
chr2:197018911(-) A-I      intronic
chr2:197016955(-) A-I      intronic
chr2:197006373(-) A-I      intronic
chr2:197016891(-) A-I      intronic
chr2:197016959(-) A-I      intronic
chr2:197018875(-) A-I      intronic
chr2:197017060(-) A-I      intronic
chr2:197016969(-) A-I      intronic
chr2:197012604(-) A-I      intronic
chr2:197006367(-) A-I      intronic
chr2:197016995(-) A-I      intronic
chr2:197017082(-) A-I      intronic
chr2:197017077(-) A-I      intronic
chr2:197010952(-) A-I      intronic
chr2:197017795(-) A-I      intronic
chr2:197011088(-) A-I      intronic
chr2:197016977(-) A-I      intronic
chr2:197016885(-) A-I      intronic
chr2:197026381(-) A-I      intronic
chr2:197017005(-) A-I      intronic
chr2:197018736(-) A-I      intronic
chr2:197018718(-) A-I      intronic
chr2:197006921(-) A-I      intronic
chr2:197011020(-) A-I      intronic
chr2:197013945(-) A-I      intronic
chr2:197010986(-) A-I      intronic
chr2:197016942(-) A-I      intronic
chr2:197027551(-) A-I      intronic
chr2:197014057(-) A-I      intronic
chr2:197018830(-) A-I      intronic
chr2:197018748(-) A-I      intronic
chr2:197006149(-) A-I      intronic
chr2:197011038(-) A-I      intronic
chr2:197012681(-) A-I      intronic
chr2:197005303(-) A-I      intronic
chr2:197012584(-) A-I      intronic
chr2:197027439(-) A-I      intronic
chr2:197018834(-) A-I      intronic
chr2:197006271(-) A-I      intronic
chr2:197006195(-) A-I      intronic
chr2:197006211(-) A-I      intronic
chr2:197024199(-) A-I      intronic
chr2:197018732(-) A-I      intronic
chr2:197018814(-) A-I      intronic
chr2:197023652(-) A-I      intronic
chr2:197014056(-) A-I      intronic
chr2:197011145(-) A-I      intronic
chr2:197024163(-) A-I      intronic
chr2:197017003(-) A-I      intronic
chr2:197018705(-) A-I      intronic
chr2:197006874(-) A-I      intronic
chr2:197007061(-) A-I      intronic
chr2:197018766(-) A-I      intronic
chr2:197012620(-) A-I      intronic
chr2:197024132(-) A-I      intronic
chr2:197010996(-) A-I      intronic
chr2:197016106(-) A-I      intronic
chr2:197026367(-) A-I      intronic
chr2:197024195(-) A-I      intronic
chr2:197011194(-) A-I      intronic
chr2:197026441(-) A-I      intronic
chr2:197024145(-) A-I      intronic
chr2:197011152(-) A-I      intronic
chr2:197027506(-) A-I      intronic
chr2:197006352(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED STK17B
chr2:197017795(-) A-I intron -    15342557
chr2:197018402(-) A-I intron -    15342557
chr2:197018717(-) A-I intron -    15342557   //15258596
chr2:197018766(-) A-I intron -    15342557   //15258596
chr2:197018767(-) A-I intron -    15342557   //15258596
chr2:197018801(-) A-I intron -    15342557   //15258596
chr2:197018830(-) A-I intron -    15342557   //15258596
chr2:197018846(-) A-I intron -    15342557   //15258596
chr2:197018875(-) A-I intron -    15342557
chr2:197000389(-) G-C exon 3'UTR    22484847
chr2:197006121(-) A-G intron -    22484847
chr2:197006195(-) A-G intron -    22484847
chr2:197006211(-) A-G intron -    22484847
chr2:197006261(-) A-G intron -    22484847
chr2:197006271(-) A-G intron -    22484847
chr2:197006352(-) A-G intron -    22484847
chr2:197006367(-) A-G intron -    22484847
chr2:197006373(-) A-G intron -    22484847
chr2:197006375(-) A-G intron -    22484847
chr2:197006874(-) A-G intron -    22484847
chr2:197006875(-) A-G intron -    22484847
chr2:197006921(-) A-G intron -    22484847
chr2:197007061(-) A-G intron -    22484847
chr2:197011100(-) A-G intron -    22484847
chr2:197011145(-) A-G intron -    22484847
chr2:197011194(-) A-G intron -    22484847
chr2:197012725(-) A-G intron -    22484847
chr2:197014057(-) A-G intron -    22484847
chr2:197017795(-) A-G intron -    22484847
chr2:197018732(-) A-G intron -    22484847
chr2:197018793(-) A-G intron -    22484847
chr2:197018801(-) A-G intron -    22484847
chr2:197018814(-) A-G intron -    22484847
chr2:197018830(-) A-G intron -    22484847
chr2:197018836(-) A-G intron -    22484847
chr2:197018846(-) A-G intron -    22484847
chr2:197018858(-) A-G intron -    22484847
chr2:197023652(-) A-G intron -    22484847
chr2:197024132(-) A-G intron -    22484847
chr2:197024282(-) A-G intron -    22484847
chr2:197026441(-) A-G intron -    22484847
chr2:197027439(-) A-G intron -    22484847
chr2:197027502(-) A-G intron -    22484847
chr2:197027506(-) A-G intron -    22484847
chr2:197027551(-) A-G intron -    22484847
chr2:197027557(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase STK17B
chr2:196999511-196999512(-) m6A 3'UTR       26404942
chr2:196999647-196999648(-) m6A 3'UTR       26404942
chr2:197001026-197001027(-) m6A 3'UTR       26404942
chr2:197001039-197001040(-) m6A 3'UTR       26404942
chr2:197001889-197001890(-) m6A 3'UTR       27773535
chr2:197002145-197002146(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22608085
chr2:197002194-197002195(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr2:197002273-197002274(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr2:197002292-197002293(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr2:197002316-197002317(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr2:197002321-197002322(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr2:197002352-197002353(-) m6A CDS       24284625//24981863//28052920//26404942//27773535//27371828//22608085
chr2:197002370-197002371(-) m6A CDS       24284625//24981863//26404942//27773535//27371828//22608085
chr2:197002390-197002391(-) m6A CDS       24284625//24981863//26404942//27773535//27371828//22608085
chr2:197002399-197002400(-) m6A CDS       24284625//24981863//26404942//27773535//27371828//22608085
chr2:197002446-197002447(-) m6A CDS       24981863//26404942//22608085
chr2:197004376-197004377(-) m6A CDS       24981863//27773535//22608085
chr2:197004407-197004408(-) m6A CDS       27773535
chr2:197004452-197004453(-) m6A CDS       27773535
chr2:197021353-197021354(-) m6A CDS       24981863//26404942//27773535
chr2:197028027-197028028(-) m6A CDS       26404942//27773535
chr2:197028124-197028125(-) m6A 5'UTR       27773535
chr2:197036074-197036075(-) m6A 5'UTR//intron       27371828
chr2:197036108-197036109(-) m6A 5'UTR//intron       27371828
chr2:197036142-197036143(-) m6A 5'UTR//intron       24981863//27371828

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate STK17B
Cytosol K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: STK17B

Evidence Support:


Strong-Evidence RISC-IP
Prediction-Evidence PITA//Targetscan
Support Database ViRBase//VmiReg

References:


PMID 20585629 Target region 5'UTR
Source ViRBase//VmiReg Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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