Basic Information:

  VIRBase ID:  

VHID00507414

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          MFHAS1:  NM_004225     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	MFHAS1
miRBase Accession/Entrez ID	MIMAT0001581	9258
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	LRRC65//MASL1//ROCO4

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	MFHAS1	chr8:8744529(-) A-I      intronic chr8:8724024(-) A-I      intronic chr8:8742449(-) A-I      intronic chr8:8644769(-) A-I      intronic chr8:8644770(-) A-I      intronic chr8:8644869(-) A-I      intronic chr8:8646142(-) A-I      intronic chr8:8646143(-) A-I      intronic chr8:8646145(-) A-I      intronic chr8:8646183(-) A-I      intronic chr8:8649854(-) A-I      intronic chr8:8655938(-) A-I      intronic chr8:8663345(-) A-I      intronic chr8:8663372(-) A-I      intronic chr8:8677015(-) A-I      intronic chr8:8677028(-) A-I      intronic chr8:8682752(-) A-I      intronic chr8:8682853(-) A-I      intronic chr8:8684121(-) A-I      intronic chr8:8684131(-) A-I      intronic chr8:8742218(-) A-I      intronic chr8:8684134(-) A-I      intronic chr8:8738332(-) A-I      intronic chr8:8738303(-) A-I      intronic chr8:8738297(-) A-I      intronic chr8:8738287(-) A-I      intronic chr8:8736740(-) A-I      intronic chr8:8736696(-) A-I      intronic chr8:8736656(-) A-I      intronic chr8:8734361(-) A-I      intronic chr8:8734107(-) A-I      intronic chr8:8734097(-) A-I      intronic chr8:8724001(-) A-I      intronic chr8:8723997(-) A-I      intronic chr8:8723996(-) A-I      intronic chr8:8716823(-) A-I      intronic chr8:8715268(-) A-I      intronic chr8:8715239(-) A-I      intronic chr8:8715122(-) A-I      intronic chr8:8715111(-) A-I      intronic chr8:8712730(-) A-I      intronic chr8:8738286(-) A-I      intronic chr8:8706855(-) A-I      intronic chr8:8706847(-) A-I      intronic chr8:8706798(-) A-I      intronic chr8:8706787(-) A-I      intronic chr8:8686973(-) A-I      intronic chr8:8706786(-) A-I      intronic chr8:8706784(-) A-I      intronic chr8:8686974(-) A-I      intronic chr8:8687189(-) A-I      intronic chr8:8689215(-) A-I      intronic chr8:8689216(-) A-I      intronic chr8:8706770(-) A-I      intronic chr8:8706769(-) A-I      intronic chr8:8706761(-) A-I      intronic chr8:8733285(-) A-I      intronic chr8:8689312(-) A-I      intronic chr8:8693986(-) A-I      intronic chr8:8728903(-) A-I      intronic chr8:8728483(-) A-I      intronic chr8:8694058(-) A-I      intronic chr8:8694100(-) A-I      intronic chr8:8694115(-) A-I      intronic chr8:8695067(-) A-I      intronic chr8:8712509(-) A-I      intronic chr8:8698817(-) A-I      intronic chr8:8711838(-) A-I      intronic chr8:8698822(-) A-I      intronic chr8:8698866(-) A-I      intronic chr8:8698873(-) A-I      intronic chr8:8698952(-) A-I      intronic chr8:8699734(-) A-I      intronic chr8:8699824(-) A-I      intronic chr8:8699833(-) A-I      intronic chr8:8711270(-) A-I      intronic chr8:8711258(-) A-I      intronic chr8:8711254(-) A-I      intronic chr8:8711252(-) A-I      intronic chr8:8711215(-) A-I      intronic chr8:8711214(-) A-I      intronic chr8:8711201(-) A-I      intronic chr8:8711153(-) A-I      intronic chr8:8711142(-) A-I      intronic chr8:8709840(-) A-I      intronic chr8:8708196(-) A-I      intronic chr8:8699927(-) A-I      intronic chr8:8703680(-) A-I      intronic chr8:8706680(-) A-I      intronic chr8:8706699(-) A-I      intronic chr8:8706702(-) A-I      intronic chr8:8706863(-) A-I      intronic chr8:8706864(-) A-I      intronic chr8:8708095(-) A-I      intronic chr8:8711221(-) A-I      intronic chr8:8739703(-) A-I      intronic chr8:8711864(-) A-I      intronic chr8:8712735(-) A-I      intronic chr8:8711322(-) A-I      intronic chr8:8704719(-) A-I      intronic chr8:8708109(-) A-I      intronic chr8:8743791(-) A-I      intronic chr8:8712512(-) A-I      intronic chr8:8740010(-) A-I      intronic chr8:8744554(-) A-I      intronic chr8:8712695(-) A-I      intronic chr8:8690204(-) A-I      intronic chr8:8743401(-) A-I      intronic chr8:8711109(-) A-I      intronic chr8:8741489(-) A-I      intronic chr8:8689344(-) A-I      intronic chr8:8695070(-) A-I      intronic chr8:8706707(-) A-I      intronic chr8:8733212(-) A-I      intronic chr8:8742365(-) A-I      intronic chr8:8712148(-) A-I      intronic chr8:8709901(-) A-I      intronic chr8:8708252(-) A-I      intronic chr8:8733269(-) A-I      intronic chr8:8684191(-) A-I      intronic chr8:8711752(-) A-I      intronic chr8:8712522(-) A-I      intronic chr8:8712517(-) A-I      intronic chr8:8712109(-) A-I      intronic chr8:8649940(-) A-I      intronic chr8:8688181(-) A-I      intronic chr8:8742287(-) A-I      intronic chr8:8734565(-) A-I      intronic chr8:8709872(-) A-I      intronic chr8:8734349(-) A-I      intronic chr8:8703600(-) A-I      intronic chr8:8706837(-) A-I      intronic chr8:8706833(-) A-I      intronic chr8:8711867(-) A-I      intronic chr8:8689301(-) A-I      intronic chr8:8698819(-) A-I      intronic chr8:8743924(-) A-I      intronic chr8:8663442(-) A-I      intronic chr8:8711993(-) A-I      intronic chr8:8644862(-) A-I      intronic chr8:8728506(-) A-I      intronic chr8:8739634(-) A-I      intronic chr8:8712073(-) A-I      intronic chr8:8738363(-) A-I      intronic chr8:8649860(-) A-I      intronic chr8:8706760(-) A-I      intronic chr8:8723967(-) A-I      intronic chr8:8738364(-) A-I      intronic chr8:8670292(-) A-I      intronic chr8:8738377(-) A-I      intronic chr8:8711182(-) A-I      intronic chr8:8733265(-) A-I      intronic chr8:8698863(-) A-I      intronic chr8:8706755(-) A-I      intronic chr8:8656315(-) A-I      intronic chr8:8695071(-) A-I      intronic chr8:8738374(-) A-I      intronic chr8:8689311(-) A-I      intronic chr8:8716732(-) A-I      intronic chr8:8677051(-) A-I      intronic chr8:8656308(-) A-I      intronic chr8:8699860(-) A-I      intronic chr8:8698885(-) A-I      intronic chr8:8690277(-) A-I      intronic chr8:8688155(-) A-I      intronic chr8:8711192(-) A-I      intronic chr8:8744474(-) A-I      intronic chr8:8722704(-) A-I      intronic chr8:8711279(-) A-I      intronic chr8:8682755(-) A-I      intronic chr8:8725340(-) A-I      intronic chr8:8738432(-) A-I      intronic chr8:8711253(-) A-I      intronic chr8:8733369(-) A-I      intronic chr8:8724003(-) A-I      intronic chr8:8682962(-) A-I      intronic chr8:8706759(-) A-I      intronic chr8:8744525(-) A-I      intronic chr8:8712112(-) A-I      intronic chr8:8708272(-) A-I      intronic chr8:8689283(-) A-I      intronic chr8:8690200(-) A-I      intronic chr8:8706850(-) A-I      intronic chr8:8742312(-) A-I      intronic chr8:8664349(-) A-I      intronic chr8:8687091(-) A-I      intronic chr8:8711724(-) A-I      intronic chr8:8663376(-) A-I      intronic chr8:8734764(-) A-I      intronic chr8:8706870(-) A-I      intronic chr8:8684031(-) A-I      intronic chr8:8706758(-) A-I      intronic chr8:8706794(-) A-I      intronic chr8:8733238(-) A-I      intronic chr8:8711741(-) A-I      intronic chr8:8655898(-) A-I      intronic chr8:8667719(-) A-I      intronic chr8:8743804(-) A-I      intronic chr8:8738399(-) A-I      intronic chr8:8703597(-) A-I      intronic chr8:8698734(-) A-I      intronic chr8:8691553(-) A-I      intronic chr8:8711873(-) A-I      intronic chr8:8686999(-) A-I      intronic chr8:8743928(-) A-I      intronic chr8:8708177(-) A-I      intronic chr8:8716771(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	MFHAS1	chr8:8663376(-) A-G intron -    22484847 chr8:8663442(-) A-G intron -    22484847 chr8:8682755(-) A-G intron -    22484847 chr8:8682820(-) A-G intron -    22484847 chr8:8682962(-) A-G intron -    22484847 chr8:8684191(-) A-G intron -    22484847 chr8:8686999(-) A-G intron -    22484847 chr8:8687091(-) A-G intron -    22484847 chr8:8690918(-) G-A intron -    22484847 chr8:8695070(-) A-G intron -    22484847 chr8:8695071(-) A-G intron -    22484847 chr8:8697801(-) A-G intron -    22484847 chr8:8697804(-) A-G intron -    22484847 chr8:8698819(-) A-G intron -    22484847 chr8:8698863(-) A-G intron -    22484847 chr8:8698885(-) A-G intron -    22484847 chr8:8698940(-) A-G intron -    22484847 chr8:8699820(-) A-G intron -    22484847 chr8:8706755(-) A-G intron -    22484847 chr8:8706758(-) A-G intron -    22484847 chr8:8706759(-) A-G intron -    22484847 chr8:8706760(-) A-G intron -    22484847 chr8:8706850(-) A-G intron -    22484847 chr8:8706870(-) A-G intron -    22484847 chr8:8708182(-) A-G intron -    22484847 chr8:8708252(-) A-G intron -    22484847 chr8:8709872(-) A-G intron -    22484847 chr8:8709901(-) A-G intron -    22484847 chr8:8711221(-) A-G intron -    22484847 chr8:8711237(-) A-G intron -    22484847 chr8:8711255(-) A-G intron -    22484847 chr8:8711275(-) A-G intron -    22484847 chr8:8711279(-) A-G intron -    22484847 chr8:8711322(-) A-G intron -    22484847 chr8:8711752(-) A-G intron -    22484847 chr8:8711842(-) A-G intron -    22484847 chr8:8711864(-) A-G intron -    22484847 chr8:8711873(-) A-G intron -    22484847 chr8:8711993(-) A-G intron -    22484847 chr8:8712073(-) A-G intron -    22484847 chr8:8712109(-) A-G intron -    22484847 chr8:8712119(-) A-G intron -    22484847 chr8:8712138(-) A-G intron -    22484847 chr8:8712148(-) A-G intron -    22484847 chr8:8712149(-) A-G intron -    22484847 chr8:8712512(-) A-G intron -    22484847 chr8:8712517(-) A-G intron -    22484847 chr8:8712522(-) A-G intron -    22484847 chr8:8713290(-) A-G intron -    22484847 chr8:8723993(-) A-G intron -    22484847 chr8:8728506(-) A-G intron -    22484847 chr8:8728516(-) A-G intron -    22484847 chr8:8733212(-) A-G intron -    22484847 chr8:8733225(-) A-G intron -    22484847 chr8:8733238(-) A-G intron -    22484847 chr8:8733265(-) A-G intron -    22484847 chr8:8733268(-) A-G intron -    22484847 chr8:8733269(-) A-G intron -    22484847 chr8:8733369(-) A-G intron -    22484847 chr8:8733376(-) A-G intron -    22484847 chr8:8734381(-) A-G intron -    22484847 chr8:8734382(-) A-G intron -    22484847 chr8:8739703(-) A-G intron -    22484847 chr8:8741129(-) T-C intron -    22484847 chr8:8742287(-) A-G intron -    22484847 chr8:8743384(-) A-G intron -    22484847 chr8:8743400(-) A-G intron -    22484847 chr8:8743401(-) A-G intron -    22484847 chr8:8743402(-) A-T intron -    22484847 chr8:8744474(-) A-G intron -    22484847 chr8:8744525(-) A-G intron -    22484847 chr8:8744554(-) A-G intron -    22484847 chr8:8744555(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	MFHAS1	chr8:8643301-8643302(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr8:8643309-8643310(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr8:8643336-8643337(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22608085 chr8:8643425-8643426(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr8:8643457-8643458(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr8:8643478-8643479(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr8:8643486-8643487(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr8:8643505-8643506(-) Gm 3'UTR//exon       - chr8:8643538-8643539(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085 chr8:8647863-8647864(-) m6A exon//intron       24284625//24209618//27773535//27371828//22608085 chr8:8654978-8654979(-) m6A CDS//exon       24284625//24981863//27773535//27371828//22608085 chr8:8679419-8679420(-) m6A exon//intron       24284625//27773535 chr8:8747643-8747644(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085 chr8:8747673-8747674(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085 chr8:8747708-8747709(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085 chr8:8747752-8747753(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085 chr8:8747778-8747779(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr8:8747966-8747967(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr8:8748063-8748064(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr8:8748084-8748085(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr8:8748121-8748122(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr8:8748234-8748235(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr8:8748302-8748303(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr8:8748354-8748355(-) Y CDS       26075521 chr8:8748415-8748416(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr8:8748475-8748476(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr8:8748514-8748515(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr8:8748564-8748565(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr8:8748649-8748650(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr8:8748676-8748677(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr8:8748763-8748764(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr8:8748769-8748770(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr8:8748820-8748821(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr8:8748864-8748865(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr8:8748910-8748911(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr8:8748949-8748950(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085 chr8:8749243-8749244(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr8:8749301-8749302(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085 chr8:8749374-8749375(-) m6A CDS       24284625//24209618//25456834//24981863//27371828//27773536//22575960//22608085 chr8:8749447-8749448(-) m6A CDS       24284625//24981863//27371828//22575960//22608085 chr8:8749513-8749514(-) m6A CDS       24284625//22575960//22608085 chr8:8749561-8749562(-) m6A CDS       24284625//22575960 chr8:8749795-8749796(-) m6A CDS       24284625 chr8:8750278-8750279(-) m6A CDS       25456834//24981863//27371828//27773536//22608085 chr8:8750353-8750354(-) m6A CDS       25456834//27371828//27773536//22608085 chr8:8750362-8750363(-) m6A CDS       25456834//27371828//27773536//22608085 chr8:8750377-8750378(-) m6A CDS       25456834//27371828//27773536//22608085 chr8:8750537-8750538(-) m6A CDS       24284625//24209618//25456834//27371828//27773536 chr8:8750554-8750555(-) m6A CDS       24284625//24209618//25456834//27371828//27773536 chr8:8750695-8750696(-) m6A 5'UTR       24209618//27371828 chr8:8751064-8751065(-) m6A 5'UTR       24209618//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	MFHAS1	Chromatin K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: MFHAS1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.