Basic Information:

  VIRBase ID:  

VHID00507266

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          SLC7A6:  NM_003983     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	SLC7A6
miRBase Accession/Entrez ID	MIMAT0001581	9057
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	LAT-2//LAT3//y+LAT-2

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC7A6	chr16:68330078(+) A-I      intronic chr16:68299676(+) A-I      intronic chr16:68313535(+) A-I      intronic chr16:68313506(+) A-I      intronic chr16:68321164(+) A-I      intronic chr16:68321133(+) A-I      intronic chr16:68320915(+) A-I      intronic chr16:68316795(+) A-I      intronic chr16:68316782(+) A-I      intronic chr16:68316601(+) A-I      intronic chr16:68316262(+) A-I      intronic chr16:68316208(+) A-I      intronic chr16:68313608(+) A-I      intronic chr16:68313590(+) A-I      intronic chr16:68313583(+) A-I      intronic chr16:68313581(+) A-I      intronic chr16:68313571(+) A-I      intronic chr16:68313497(+) A-I      intronic chr16:68313453(+) A-I      intronic chr16:68313227(+) A-I      intronic chr16:68313194(+) A-I      intronic chr16:68313178(+) A-I      intronic chr16:68313141(+) A-I      intronic chr16:68313124(+) A-I      intronic chr16:68313019(+) A-I      intronic chr16:68311631(+) A-I      intronic chr16:68311175(+) A-I      intronic chr16:68311164(+) A-I      intronic chr16:68311091(+) A-I      intronic chr16:68311090(+) A-I      intronic chr16:68310863(+) A-I      intronic chr16:68310802(+) A-I      intronic chr16:68310651(+) A-I      intronic chr16:68309404(+) A-I      intronic chr16:68309312(+) A-I      intronic chr16:68309252(+) A-I      intronic chr16:68306121(+) A-I      intronic chr16:68306115(+) A-I      intronic chr16:68305958(+) A-I      intronic chr16:68305893(+) A-I      intronic chr16:68305846(+) A-I      intronic chr16:68305834(+) A-I      intronic chr16:68305798(+) A-I      intronic chr16:68305727(+) A-I      intronic chr16:68299935(+) A-I      intronic chr16:68318781(+) A-I      intronic chr16:68320925(+) A-I      intronic chr16:68313200(+) A-I      intronic chr16:68303536(+) A-I      intronic chr16:68305343(+) A-I      intronic chr16:68313080(+) A-I      intronic chr16:68305308(+) A-I      intronic chr16:68313653(+) A-I      intronic chr16:68310783(+) A-I      intronic chr16:68303887(+) A-I      intronic chr16:68322746(+) A-I      intronic chr16:68313170(+) A-I      intronic chr16:68309313(+) A-I      intronic chr16:68321020(+) A-I      intronic chr16:68316290(+) A-I      intronic chr16:68316225(+) A-I      intronic chr16:68319813(+) A-I      intronic chr16:68313230(+) A-I      intronic chr16:68300042(+) A-I      intronic chr16:68319766(+) A-I      intronic chr16:68303523(+) A-I      intronic chr16:68309342(+) A-I      intronic chr16:68316725(+) A-I      intronic chr16:68321155(+) A-I      intronic chr16:68313467(+) A-I      intronic chr16:68313130(+) A-I      intronic chr16:68311070(+) A-I      intronic chr16:68313614(+) A-I      intronic chr16:68305326(+) A-I      intronic chr16:68305928(+) A-I      intronic chr16:68309377(+) A-I      intronic chr16:68313465(+) A-I      intronic chr16:68305164(+) A-I      intronic chr16:68310741(+) A-I      intronic chr16:68306284(+) A-I      intronic chr16:68316239(+) A-I      intronic chr16:68309309(+) A-I      intronic chr16:68311129(+) A-I      intronic chr16:68312989(+) A-I      intronic chr16:68311587(+) A-I      intronic chr16:68311015(+) A-I      intronic chr16:68306277(+) A-I      intronic chr16:68310672(+) A-I      intronic chr16:68311013(+) A-I      intronic chr16:68310645(+) A-I      intronic chr16:68314843(+) A-I      intronic chr16:68310850(+) A-I      intronic chr16:68319806(+) A-I      intronic chr16:68321157(+) A-I      intronic chr16:68310623(+) A-I      intronic chr16:68310853(+) A-I      intronic chr16:68316723(+) A-I      intronic chr16:68316540(+) A-I      intronic chr16:68316737(+) A-I      intronic chr16:68313090(+) A-I      intronic chr16:68320974(+) A-I      intronic chr16:68303582(+) A-I      intronic chr16:68316293(+) A-I      intronic chr16:68313689(+) A-I      intronic chr16:68313461(+) A-I      intronic chr16:68303895(+) A-I      intronic chr16:68316243(+) A-I      intronic chr16:68305847(+) A-I      intronic chr16:68305779(+) A-I      intronic chr16:68306343(+) A-I      intronic chr16:68310847(+) A-I      intronic chr16:68303923(+) A-I      intronic chr16:68327057(+) A-I      intronic chr16:68310717(+) A-I      intronic chr16:68312984(+) A-I      intronic chr16:68311803(+) A-I      intronic chr16:68320966(+) A-I      intronic chr16:68309244(+) A-I      intronic chr16:68319785(+) A-I      intronic chr16:68303596(+) A-I      intronic chr16:68311046(+) A-I      intronic chr16:68316238(+) A-I      intronic chr16:68310743(+) A-I      intronic chr16:68311177(+) A-I      intronic chr16:68309334(+) A-I      intronic chr16:68326448(+) A-I      intronic chr16:68312040(+) A-I      intronic chr16:68306257(+) A-I      intronic chr16:68320980(+) A-I      intronic chr16:68303607(+) A-I      intronic chr16:68305785(+) A-I      intronic chr16:68310706(+) A-I      intronic chr16:68306315(+) A-I      intronic chr16:68311069(+) A-I      intronic chr16:68319983(+) A-I      intronic chr16:68319982(+) A-I      intronic chr16:68312967(+) A-I      intronic chr16:68306218(+) A-I      intronic chr16:68313134(+) A-I      intronic chr16:68322685(+) A-I      intronic chr16:68305170(+) A-I      intronic chr16:68310740(+) A-I      intronic chr16:68319742(+) A-I      intronic chr16:68310827(+) A-I      intronic chr16:68311997(+) A-I      intronic chr16:68316682(+) A-I      intronic chr16:68306292(+) A-I      intronic chr16:68306055(+) A-I      intronic chr16:68320955(+) A-I      intronic chr16:68319720(+) A-I      intronic chr16:68313568(+) A-I      intronic chr16:68316286(+) A-I      intronic chr16:68310759(+) A-I      intronic chr16:68311896(+) A-I      intronic chr16:68311170(+) A-I      intronic chr16:68309315(+) A-I      intronic chr16:68303578(+) A-I      intronic chr16:68310791(+) A-I      intronic chr16:68319909(+) A-I      intronic chr16:68321081(+) A-I      intronic chr16:68316660(+) A-I      intronic chr16:68310646(+) A-I      intronic chr16:68319726(+) A-I      intronic chr16:68321010(+) A-I      intronic chr16:68313029(+) A-I      intronic chr16:68322614(+) A-I      intronic chr16:68305822(+) A-I      intronic chr16:68311476(+) A-I      intronic chr16:68303514(+) A-I      intronic chr16:68312983(+) A-I      intronic chr16:68309423(+) A-I      intronic chr16:68319919(+) A-I      intronic chr16:68313639(+) A-I      intronic chr16:68305784(+) A-I      intronic chr16:68323179(+) A-I      intronic chr16:68313000(+) A-I      intronic chr16:68321143(+) A-I      intronic chr16:68306062(+) A-I      intronic chr16:68306194(+) A-I      intronic chr16:68319853(+) A-I      intronic chr16:68313567(+) A-I      intronic chr16:68311488(+) A-I      intronic chr16:68309243(+) A-I      intronic chr16:68311043(+) A-I      intronic chr16:68305729(+) A-I      intronic chr16:68313644(+) A-I      intronic chr16:68319889(+) A-I      intronic chr16:68303810(+) A-I      intronic chr16:68311131(+) A-I      intronic chr16:68310742(+) A-I      intronic chr16:68312120(+) A-I      intronic chr16:68313210(+) A-I      intronic chr16:68319892(+) A-I      intronic chr16:68310736(+) A-I      intronic chr16:68311009(+) A-I      intronic chr16:68305980(+) A-I      intronic chr16:68316216(+) A-I      intronic chr16:68320998(+) A-I      intronic chr16:68321022(+) A-I      intronic chr16:68311123(+) A-I      intronic chr16:68327272(+) A-I      intronic chr16:68312132(+) A-I      intronic chr16:68313622(+) A-I      intronic chr16:68313147(+) A-I      intronic chr16:68313006(+) A-I      intronic chr16:68311107(+) A-I      intronic chr16:68327064(+) A-I      intronic chr16:68306229(+) A-I      intronic chr16:68313677(+) A-I      intronic chr16:68311579(+) A-I      intronic chr16:68306203(+) A-I      intronic chr16:68311116(+) A-I      intronic chr16:68313702(+) A-I      intronic chr16:68313125(+) A-I      intronic chr16:68309378(+) A-I      intronic chr16:68313559(+) A-I      intronic chr16:68311119(+) A-I      intronic chr16:68320913(+) A-I      intronic chr16:68303729(+) A-I      intronic chr16:68316217(+) A-I      intronic chr16:68318842(+) A-I      intronic chr16:68310751(+) A-I      intronic chr16:68311959(+) A-I      intronic chr16:68305338(+) A-I      intronic chr16:68311051(+) A-I      intronic chr16:68313542(+) A-I      intronic chr16:68311960(+) A-I      intronic chr16:68311173(+) A-I      intronic chr16:68311611(+) A-I      intronic chr16:68317949(+) A-I      intronic chr16:68316194(+) A-I      intronic chr16:68309450(+) A-I      intronic chr16:68306361(+) A-I      intronic chr16:68317978(+) A-I      intronic chr16:68313220(+) A-I      intronic chr16:68320981(+) A-I      intronic chr16:68313625(+) A-I      intronic chr16:68309241(+) A-I      intronic chr16:68318788(+) A-I      intronic chr16:68321070(+) A-I      intronic chr16:68316783(+) A-I      intronic chr16:68306179(+) A-I      intronic chr16:68311200(+) A-I      intronic chr16:68311059(+) A-I      intronic chr16:68305769(+) A-I      intronic chr16:68307804(+) A-I      5'UTR chr16:68307767(+) A-I      5'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SLC7A6	chr16:68310783(+) A-I intron -    22327324 chr16:68319853(+) A-I intron -    22327324 chr16:68317978(+) A-G intron -    22484847 chr16:68318078(+) T-C intron -    22484847 chr16:68300923(+) T-C intron -    22484847 chr16:68306203(+) A-G intron -    22484847 chr16:68306257(+) A-G intron -    22484847 chr16:68306277(+) A-G intron -    22484847 chr16:68307767(+) A-G exon 5'UTR    22484847 chr16:68309376(+) T-C intron -    22484847 chr16:68310751(+) A-G intron -    22484847 chr16:68310783(+) A-G intron -    22484847 chr16:68310850(+) A-G intron -    22484847 chr16:68311051(+) A-G intron -    22484847 chr16:68311070(+) A-G intron -    22484847 chr16:68316238(+) A-G intron -    22484847 chr16:68316243(+) A-G intron -    22484847 chr16:68318762(+) C-T intron -    22484847 chr16:68319747(+) T-C intron -    22484847 chr16:68319853(+) A-G intron -    22484847 chr16:68320925(+) A-G intron -    22484847 chr16:68320974(+) A-G intron -    22484847 chr16:68321143(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC7A6	chr16:68308603-68308604(+) m6A 5'UTR       24284625 chr16:68308619-68308620(+) m6A 5'UTR       24284625 chr16:68308740-68308741(+) m6A CDS       24284625 chr16:68308935-68308936(+) m6A CDS//intron       24284625//22608085 chr16:68330648-68330649(+) Y 3'UTR//CDS//exon       26075521 chr16:68331222-68331223(+) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//27773535//22608085 chr16:68331293-68331294(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22575960//22608085 chr16:68331393-68331394(+) m6A 3'UTR//intron       24284625//24981863//22608085 chr16:68331939-68331940(+) m6A 3'UTR//intron       24981863//22608085 chr16:68332034-68332035(+) m6A 3'UTR//intron       24284625//24981863//22575960//22608085 chr16:68332042-68332043(+) m6A 3'UTR//intron       24284625//24981863//22575960//22608085 chr16:68332087-68332088(+) m6A 3'UTR//intron       24284625//24981863//27773535//22575960//22608085 chr16:68332109-68332110(+) m6A 3'UTR//intron       24284625//24981863//27773535//22575960//22608085 chr16:68332160-68332161(+) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr16:68332177-68332178(+) m6A 3'UTR//intron       24284625//24981863//27773535//22608085 chr16:68332233-68332234(+) m6A 3'UTR//intron       24284625//22608085 chr16:68332293-68332294(+) m6A 3'UTR//intron       24284625 chr16:68332305-68332306(+) m6A 3'UTR//intron       24284625 chr16:68332352-68332353(+) m6A 3'UTR//intron       24284625//24209618 chr16:68332435-68332436(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr16:68332517-68332518(+) m6A 3'UTR       24284625//24209618//25456834//24981863//27371828//22575960//22608085 chr16:68332550-68332551(+) m6A 3'UTR       24284625//24209618//25456834//24981863//22575960//22608085 chr16:68332733-68332734(+) m6A 3'UTR       24284625//24209618//24981863//26404942//22575960//22608085 chr16:68332758-68332759(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr16:68333344-68333345(+) m6A 3'UTR       27773535 chr16:68333795-68333796(+) m6A 3'UTR       27773535 chr16:68333844-68333845(+) m6A 3'UTR       24981863//27773535 chr16:68334362-68334363(+) m6A 3'UTR       27773535 chr16:68334448-68334449(+) m6A 3'UTR       27773535 chr16:68334545-68334546(+) m6A 3'UTR       27773535 chr16:68334912-68334913(+) m6A 3'UTR       24284625 chr16:68334946-68334947(+) m6A 3'UTR       24284625//22575960 chr16:68334999-68335000(+) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085 chr16:68335090-68335091(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:68335125-68335126(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:68335154-68335155(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:68335163-68335164(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr16:68335173-68335174(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr16:68335215-68335216(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr16:68335647-68335648(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SLC7A6	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: SLC7A6

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.