Basic Information:

  VIRBase ID:  

VHID00507241

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7903

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          HIP1R:  NM_001303097     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	HIP1R
miRBase Accession/Entrez ID	MIMAT0001581	9026
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	HIP12//HIP3//ILWEQ

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HIP1R	chr12:123326000(+) A-I      intronic chr12:123326001(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HIP1R	chr12:123319543-123319544(+) m6A exon       24209618 chr12:123319548-123319549(+) m6A exon       24209618 chr12:123320039-123320040(+) m6A 5'UTR//exon//intron       24284625//24209618 chr12:123320073-123320074(+) m6A 5'UTR//exon//intron       24284625//24209618 chr12:123320101-123320102(+) m6A CDS//exon//intron       24284625//24209618 chr12:123320184-123320185(+) m6A CDS//exon//intron       24284625//24209618 chr12:123340129-123340130(+) m6A CDS//exon       24209618 chr12:123340379-123340380(+) m6A CDS//exon       24209618 chr12:123340428-123340429(+) m6A CDS//exon       24209618 chr12:123340985-123340986(+) m6A CDS//exon       24284625//24209618//25456834//24981863//22575960 chr12:123341595-123341596(+) m6A CDS//exon       24284625//24209618 chr12:123341652-123341653(+) m6A CDS//exon       24284625//24209618 chr12:123341684-123341685(+) m6A CDS//exon       24284625//24209618 chr12:123341992-123341993(+) m6A exon//intron       26404942 chr12:123342030-123342031(+) m6A exon//intron       24284625//26404942 chr12:123342106-123342107(+) m6A exon//intron       24284625//24981863//26404942//22608085 chr12:123342151-123342152(+) m6A exon//intron       24284625//24981863//22608085 chr12:123342161-123342162(+) m6A exon//intron       24284625//24981863//22608085 chr12:123342196-123342197(+) m6A exon//intron       24284625//24981863//22608085 chr12:123342204-123342205(+) m6A exon//intron       24284625//24981863//22608085 chr12:123343616-123343617(+) m6A CDS//exon       24284625 chr12:123343974-123343975(+) m6A CDS//exon       24209618 chr12:123343980-123343981(+) m6A CDS//exon       24209618 chr12:123344328-123344329(+) m6A CDS//exon       24284625//24209618//24981863 chr12:123344613-123344614(+) m6A CDS//exon       24284625//24209618 chr12:123344830-123344831(+) m6A exon//intron       24209618 chr12:123345003-123345004(+) m6A CDS//exon//intron       24209618 chr12:123345014-123345015(+) m6A CDS//exon//intron       24209618 chr12:123346012-123346013(+) m6A CDS//exon       24284625 chr12:123346048-123346049(+) m6A CDS//exon       24284625 chr12:123346053-123346054(+) m6A CDS//exon       24284625 chr12:123346155-123346156(+) m6A exon//intron       24284625 chr12:123346292-123346293(+) m6A CDS//exon       24284625 chr12:123346364-123346365(+) m6A 3'UTR//exon       24284625//24209618//24981863 chr12:123346520-123346521(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr12:123346539-123346540(+) m6A 3'UTR//exon       24284625//24209618//24981863//22608085 chr12:123346665-123346666(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22608085 chr12:123346697-123346698(+) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//22608085 chr12:123346828-123346829(+) m6A 3'UTR//exon       25456834 chr12:123346958-123346959(+) m6A 3'UTR//exon       24284625 chr12:123347155-123347156(+) m6A 3'UTR       24284625 chr12:123347168-123347169(+) m6A 3'UTR       24284625

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	HIP1R	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: HIP1R

Evidence Support:

Strong-Evidence	RISC-IP
Prediction-Evidence	miRanda//RNAHybrid
Support Database	ViRBase//VmiReg

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.