Basic Information:

  VIRBase ID:  

VHID00507186

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          HERC3:  NM_001271602     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	HERC3
miRBase Accession/Entrez ID	MIMAT0001581	8916
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HERC3	chr4:89543982(+) A-I      intronic chr4:89610472(+) A-I      intronic chr4:89523350(+) A-I      intronic chr4:89610859(+) A-I      intronic chr4:89610449(+) A-I      intronic chr4:89610477(+) A-I      intronic chr4:89610384(+) A-I      intronic chr4:89523513(+) A-I      intronic chr4:89523851(+) A-I      intronic chr4:89547474(+) A-I      intronic chr4:89547450(+) A-I      intronic chr4:89628436(+) A-I      3'UTR chr4:89610470(+) A-I      intronic chr4:89523899(+) A-I      intronic chr4:89523828(+) A-I      intronic chr4:89515629(+) A-I      intronic chr4:89610590(+) A-I      intronic chr4:89626192(+) A-I      intronic chr4:89610929(+) A-I      intronic chr4:89548799(+) A-I      intronic chr4:89610454(+) A-I      intronic chr4:89610585(+) A-I      intronic chr4:89530184(+) A-I      intronic chr4:89610400(+) A-I      intronic chr4:89523703(+) A-I      intronic chr4:89610909(+) A-I      intronic chr4:89515667(+) A-I      intronic chr4:89531394(+) A-I      intronic chr4:89515694(+) A-I      intronic chr4:89515680(+) A-I      intronic chr4:89531483(+) A-I      intronic chr4:89531368(+) A-I      intronic chr4:89523821(+) A-I      intronic chr4:89610870(+) A-I      intronic chr4:89548983(+) A-I      intronic chr4:89610474(+) A-I      intronic chr4:89531351(+) A-I      intronic chr4:89610862(+) A-I      intronic chr4:89610563(+) A-I      intronic chr4:89523687(+) A-I      intronic chr4:89528708(+) A-I      intronic chr4:89610938(+) A-I      intronic chr4:89610521(+) A-I      intronic chr4:89527520(+) A-I      intronic chr4:89523893(+) A-I      intronic chr4:89516132(+) A-I      intronic chr4:89610809(+) A-I      intronic chr4:89611003(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	HERC3	chr4:89610474(+) A-I intron -    21960545 chr4:89527477(+) A-G intron -    22484847 chr4:89610454(+) A-G intron -    22484847 chr4:89610474(+) A-G intron -    22484847 chr4:89610585(+) A-G intron -    22484847 chr4:89610590(+) A-G intron -    22484847 chr4:89610614(+) A-G intron -    22484847 chr4:89610809(+) A-G intron -    22484847 chr4:89610862(+) A-G intron -    22484847 chr4:89610870(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HERC3	chr4:89442487-89442488(+) m6A exon       24284625 chr4:89442542-89442543(+) m6A exon       24284625//27773535 chr4:89442553-89442554(+) m6A exon       24284625//27773535 chr4:89442641-89442642(+) m6A exon       24284625//24209618//24981863//27773535//22608085 chr4:89442879-89442880(+) m6A exon       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr4:89442896-89442897(+) m6A exon       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr4:89442911-89442912(+) m6A exon       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr4:89442930-89442931(+) m6A exon       24284625//24209618//24981863//28052920//27773535//22575960//22608085 chr4:89442936-89442937(+) m6A exon       24284625//24209618//24981863//27773535//22575960//22608085 chr4:89443037-89443038(+) m6A exon       24981863//27773535 chr4:89444682-89444683(+) m6A exon       27773535//27773536 chr4:89444867-89444868(+) m6A exon       25456834//24981863//27371828//27773536 chr4:89513659-89513660(+) m6A 5'UTR//intron       24981863 chr4:89527104-89527105(+) m6A CDS       - chr4:89527155-89527156(+) m6A CDS       - chr4:89527191-89527192(+) m6A CDS       - chr4:89601351-89601352(+) Y CDS       26075521

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	HERC3	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: HERC3

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.