Basic Information:

  VIRBase ID:  

VHID00507181

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7903

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          CACNA1I:  NM_021096     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	CACNA1I
miRBase Accession/Entrez ID	MIMAT0001581	8911
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	ca(v)3.3//Cav3.3

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CACNA1I	chr22:39984652(+) A-I      intronic chr22:40048275(+) A-I      intronic chr22:40002780(+) A-I      intronic chr22:40048655(+) A-I      intronic chr22:40003978(+) A-I      intronic chr22:39984651(+) A-I      intronic chr22:39982118(+) A-I      intronic chr22:39981931(+) A-I      intronic chr22:40048806(+) A-I      intronic chr22:40048119(+) A-I      intronic chr22:40048763(+) A-I      intronic chr22:39998958(+) A-I      intronic chr22:39991037(+) A-I      intronic chr22:40003736(+) A-I      intronic chr22:39998961(+) A-I      intronic chr22:40004567(+) A-I      intronic chr22:39999109(+) A-I      intronic chr22:39981129(+) A-I      intronic chr22:39981204(+) A-I      intronic chr22:40048803(+) A-I      intronic chr22:40048835(+) A-I      intronic chr22:39999086(+) A-I      intronic chr22:40048831(+) A-I      intronic chr22:40048768(+) A-I      intronic chr22:40048728(+) A-I      intronic chr22:40004637(+) A-I      intronic chr22:40048132(+) A-I      intronic chr22:39991039(+) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CACNA1I	chr22:40045749-40045750(+) m6A CDS       25456834 chr22:40045850-40045851(+) m6A CDS       25456834 chr22:40082297-40082298(+) m6A CDS       25456834 chr22:40084046-40084047(+) m6A 3'UTR       25456834 chr22:40084145-40084146(+) m6A 3'UTR       25456834 chr22:40084491-40084492(+) m6A 3'UTR       25456834 chr22:40084531-40084532(+) m6A 3'UTR       25456834 chr22:40084988-40084989(+) m6A 3'UTR       25456834 chr22:40085017-40085018(+) m6A 3'UTR       25456834

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CACNA1I	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: CACNA1I

Evidence Support:

Strong-Evidence	RISC-IP
Prediction-Evidence	miRanda//Targetscan
Support Database	ViRBase//VmiReg

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase//VmiReg	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.