Basic Information:

  VIRBase ID:  

VHID00507153

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          SPHK1:  NM_182965     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	SPHK1
miRBase Accession/Entrez ID	MIMAT0001581	8877
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	SPHK

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SPHK1	chr17:74379172-74379173(+) m6A exon//intron       27773536 chr17:74380873-74380874(+) m6A 5'UTR//intron       24284625 chr17:74380878-74380879(+) m6A 5'UTR//intron       24284625 chr17:74381129-74381130(+) m6A 5'UTR//intron       24209618 chr17:74381406-74381407(+) m6A 5'UTR//intron       - chr17:74381421-74381422(+) m6A 5'UTR//intron       - chr17:74381432-74381433(+) m6A 5'UTR//intron       - chr17:74381501-74381502(+) m6A 5'UTR//intron       - chr17:74381840-74381841(+) m6A exon//intron       - chr17:74382310-74382311(+) m6A CDS//exon       24284625 chr17:74382402-74382403(+) m6A exon//intron       24284625 chr17:74382909-74382910(+) m6A CDS//exon       22575960 chr17:74382963-74382964(+) m6A CDS//exon       24284625//22575960 chr17:74383044-74383045(+) m6A CDS//exon       24284625//24981863//22575960 chr17:74383175-74383176(+) m6A CDS//exon       24284625//24981863//22575960//22608085 chr17:74383259-74383260(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085 chr17:74383278-74383279(+) m6A CDS//exon       24284625//25456834//24981863//22575960//22608085 chr17:74383581-74383582(+) m6A CDS//exon       - chr17:74383705-74383706(+) m6A 3'UTR//exon       24284625 chr17:74383765-74383766(+) m6A 3'UTR//exon       - chr17:74383811-74383812(+) m6A 3'UTR//exon       - chr17:74383893-74383894(+) m6A 3'UTR//exon       - chr17:74383908-74383909(+) m6A 3'UTR//exon       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SPHK1	Exosome Blood     - Nucleolus K562 cells     - Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: SPHK1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.