Basic Information:

  VIRBase ID:  

VHID00507004

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          PEA15:  NR_123724     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	PEA15
miRBase Accession/Entrez ID	MIMAT0001581	8682
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	HMAT1//HUMMAT1H//MAT1//MAT1H//PEA-15//PED//PED-PEA15//PED/PEA15

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PEA15	chr1:160175263-160175264(+) m6A 5'UTR       24284625//24209618//24981863 chr1:160175270-160175271(+) m6A 5'UTR       24284625//24209618//24981863 chr1:160176968-160176969(+) m6A 5'UTR//intron       24284625//24209618//24981863 chr1:160178410-160178411(+) m6A CDS//intron       24209618 chr1:160178445-160178446(+) m6A CDS//intron       24209618 chr1:160181349-160181350(+) m6A CDS//exon       24209618//24981863 chr1:160181362-160181363(+) m6A CDS//exon       24209618//24981863 chr1:160181396-160181397(+) m6A CDS//exon       24209618//24981863 chr1:160181422-160181423(+) m6A CDS//exon       24209618//24981863 chr1:160181500-160181501(+) m6A CDS//exon//intron       24981863 chr1:160182976-160182977(+) m6A CDS//exon       24981863 chr1:160183013-160183014(+) m6A CDS//exon       24981863 chr1:160183305-160183306(+) m6A 3'UTR//exon       26404942 chr1:160183630-160183631(+) m6A 3'UTR       24981863 chr1:160183726-160183727(+) m6A 3'UTR       24981863 chr1:160184159-160184160(+) m6A 3'UTR       - chr1:160184236-160184237(+) m6A 3'UTR       - chr1:160184249-160184250(+) m6A 3'UTR       - chr1:160184289-160184290(+) m6A 3'UTR       - chr1:160184417-160184418(+) m6A 3'UTR       24981863 chr1:160184543-160184544(+) m6A 3'UTR       24981863 chr1:160184568-160184569(+) m6A 3'UTR       24981863 chr1:160184595-160184596(+) m6A 3'UTR       24981863//26404942 chr1:160184604-160184605(+) m6A 3'UTR       26404942 chr1:160184644-160184645(+) m6A 3'UTR       26404942 chr1:160184900-160184901(+) m6A 3'UTR       26404942 chr1:160184984-160184985(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PEA15	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells     - Ribosome HEK-293 cells     22199352 Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: PEA15

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.