Detail Information

Basic Information:


  VIRBase ID:  

VHID00506992

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           EIF3G:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p EIF3G
miRBase
Accession/Entrez ID		 MIMAT0001581 8666
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - eIF3-delta//EIF3-P42//eIF3-p44//EIF3S4

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR EIF3G
chr19:10228509(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase EIF3G
chr19:10225742-10225743(-) m6A 3'UTR//exon       27773535//22575960
chr19:10225759-10225760(-) m6A 3'UTR//exon       24284625//27773535//22575960
chr19:10226376-10226377(-) m6A CDS//exon       24284625//27773535//27371828//27773536//22575960
chr19:10226381-10226382(-) m6A CDS//exon       27773535//27371828//27773536//22575960
chr19:10226442-10226443(-) m6A CDS//exon       27773535//27371828//27773536//22575960
chr19:10226453-10226454(-) m6A CDS//exon       27773535//27371828//27773536//22575960
chr19:10226717-10226718(-) m6A CDS//exon       24981863//27773535//27371828//27773536//22575960
chr19:10226722-10226723(-) m6A CDS//exon       24981863//27773535//27371828//27773536//22575960
chr19:10226773-10226774(-) m6A exon//intron       24981863//27773535//27371828//27773536
chr19:10227069-10227070(-) m6A exon//intron       -
chr19:10227574-10227575(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828//27773536
chr19:10227630-10227631(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828//27773536//22575960
chr19:10227639-10227640(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828//27773536//22575960
chr19:10227657-10227658(-) m6A 3'UTR//CDS//exon       24981863//27773535//27371828//27773536//22575960
chr19:10227822-10227823(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535//27371828//27773536//22575960
chr19:10227844-10227845(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535//27371828//27773536//22575960
chr19:10227862-10227863(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535//27371828//27773536
chr19:10227913-10227914(-) m6A exon//intron       24981863//27773535//27371828//27773536
chr19:10227959-10227960(-) m6A exon//intron       27773535
chr19:10229236-10229237(-) m6A intron       27773535
chr19:10229286-10229287(-) m6A intron       27773535
chr19:10229299-10229300(-) m6A intron       27773535
chr19:10229378-10229379(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr19:10229587-10229588(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr19:10229595-10229596(-) m6A 3'UTR//CDS//exon       24981863//27773535
chr19:10229731-10229732(-) m6A exon//intron       24981863
chr19:10229752-10229753(-) m6A 3'UTR//exon//intron       24981863
chr19:10229846-10229847(-) m6A 3'UTR//CDS//exon       24981863//27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate EIF3G
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: EIF3G

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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