Basic Information:

  VIRBase ID:  

VHID00506990

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          EIF3D:  NR_156418     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	EIF3D
miRBase Accession/Entrez ID	MIMAT0001581	8664
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	eIF3-p66//eIF3-zeta//EIF3S7

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	EIF3D	chr22:36909543(-) A-I      intronic chr22:36913989(-) A-I      intronic chr22:36913966(-) A-I      intronic chr22:36914498(-) A-I      intronic chr22:36909548(-) A-I      intronic chr22:36913968(-) A-I      intronic chr22:36913932(-) A-I      intronic chr22:36911513(-) A-I      intronic chr22:36911512(-) A-I      intronic chr22:36911492(-) A-I      intronic chr22:36911443(-) A-I      intronic chr22:36911435(-) A-I      intronic chr22:36911431(-) A-I      intronic chr22:36911393(-) A-I      intronic chr22:36909577(-) A-I      intronic chr22:36909525(-) A-I      intronic chr22:36909482(-) A-I      intronic chr22:36909446(-) A-I      intronic chr22:36909379(-) A-I      intronic chr22:36909354(-) A-I      intronic chr22:36913841(-) A-I      intronic chr22:36914333(-) A-I      intronic chr22:36913910(-) A-I      intronic chr22:36914009(-) A-I      intronic chr22:36913977(-) A-I      intronic chr22:36914020(-) A-I      intronic chr22:36914381(-) A-I      intronic chr22:36911573(-) A-I      intronic chr22:36914294(-) A-I      intronic chr22:36914067(-) A-I      intronic chr22:36913971(-) A-I      intronic chr22:36923631(-) A-I      intronic chr22:36913824(-) A-I      intronic chr22:36909582(-) A-I      intronic chr22:36914436(-) A-I      intronic chr22:36911488(-) A-I      intronic chr22:36914424(-) A-I      intronic chr22:36909870(-) A-I      intronic chr22:36914320(-) A-I      intronic chr22:36913906(-) A-I      intronic chr22:36911475(-) A-I      intronic chr22:36914388(-) A-I      intronic chr22:36913847(-) A-I      intronic chr22:36909862(-) A-I      intronic chr22:36914474(-) A-I      intronic chr22:36911319(-) A-I      intronic chr22:36911413(-) A-I      intronic chr22:36911331(-) A-I      intronic chr22:36913919(-) A-I      intronic chr22:36913972(-) A-I      intronic chr22:36909631(-) A-I      intronic chr22:36914522(-) A-I      intronic chr22:36913825(-) A-I      intronic chr22:36914458(-) A-I      intronic chr22:36922769(-) A-I      intronic chr22:36913965(-) A-I      intronic chr22:36911572(-) A-I      intronic chr22:36913963(-) A-I      intronic chr22:36914370(-) A-I      intronic chr22:36909452(-) A-I      intronic chr22:36914414(-) A-I      intronic chr22:36911372(-) A-I      intronic chr22:36914453(-) A-I      intronic chr22:36913973(-) A-I      intronic chr22:36909532(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	EIF3D	chr22:36913825(-) A-I intron -    22327324 chr22:36913974(-) A-I intron -    22327324 chr22:36913977(-) A-I intron -    22327324 chr22:36914381(-) A-I intron -    22327324 chr22:36914522(-) A-I intron -    22327324 chr22:36909792(-) A-G intron -    22484847 chr22:36911572(-) A-G intron -    22484847 chr22:36911573(-) A-G intron -    22484847 chr22:36913825(-) A-G intron -    22484847 chr22:36913965(-) A-G intron -    22484847 chr22:36913971(-) A-G intron -    22484847 chr22:36913972(-) A-G intron -    22484847 chr22:36913973(-) A-G intron -    22484847 chr22:36913974(-) A-G intron -    22484847 chr22:36913977(-) A-G intron -    22484847 chr22:36914020(-) A-G intron -    22484847 chr22:36914381(-) A-G intron -    22484847 chr22:36914436(-) A-G intron -    22484847 chr22:36914522(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	EIF3D	chr22:36906994-36906995(-) m6A 3'UTR//exon       - chr22:36907032-36907033(-) m6A 3'UTR//exon       - chr22:36907038-36907039(-) m6A 3'UTR//CDS//exon       - chr22:36907099-36907100(-) m6A 3'UTR//intron       - chr22:36907139-36907140(-) m6A 3'UTR//intron       - chr22:36907650-36907651(-) m6A CDS//exon       27773535//22575960 chr22:36907806-36907807(-) m6A 3'UTR//CDS//exon       22575960 chr22:36908614-36908615(-) m6A 3'UTR//CDS//exon       22575960 chr22:36912939-36912940(-) m6A exon//intron       26404942 chr22:36913457-36913458(-) m6A 3'UTR//CDS       26404942//27773535 chr22:36913477-36913478(-) m6A CDS       27773535 chr22:36914823-36914824(-) m6A CDS       27773535 chr22:36914843-36914844(-) m6A CDS       27773535 chr22:36914947-36914948(-) m6A CDS       27773535 chr22:36916625-36916626(-) m6A CDS       26404942//27773535 chr22:36916724-36916725(-) m6A CDS       27773535 chr22:36916732-36916733(-) m6A CDS       24981863//27773535 chr22:36919294-36919295(-) m6A CDS//exon       24981863//27773535//22575960 chr22:36919952-36919953(-) m6A CDS//exon       24981863//26404942//27773535//22575960 chr22:36919995-36919996(-) m6A CDS//exon       24981863//26404942//27773535//22575960 chr22:36920010-36920011(-) m6A CDS//exon       24981863//26404942//27773535//22575960 chr22:36920022-36920023(-) m6A CDS//exon       24981863//26404942//27773535//22575960 chr22:36921727-36921728(-) Am CDS//exon       - chr22:36921743-36921744(-) m6A CDS//exon       27773535 chr22:36921748-36921749(-) m6A CDS//exon       27773535 chr22:36921804-36921805(-) m6A exon//intron       - chr22:36921853-36921854(-) m6A exon//intron       - chr22:36921865-36921866(-) m6A exon//intron       - chr22:36922136-36922137(-) m6A CDS//exon       24981863//27773535 chr22:36922942-36922943(-) m6A 5'UTR//intron       24981863 chr22:36924805-36924806(-) m6A 5'UTR//intron       24981863 chr22:36925037-36925038(-) m6A 5'UTR//intron       24981863 chr22:36925072-36925073(-) m6A 5'UTR//intron       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	EIF3D	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HeLa-S3 cells|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: EIF3D

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.