Detail Information

Basic Information:


  VIRBase ID:  

VHID00506948

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           PLPP3:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p PLPP3
miRBase
Accession/Entrez ID		 MIMAT0001581 8613
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - Dri42//LPP3//PAP2B//PPAP2B//VCIP

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PLPP3
chr1:57040110(-) A-I      intronic
chr1:57040092(-) A-I      intronic
chr1:57040097(-) A-I      intronic
chr1:57040178(-) A-I      intronic
chr1:57039790(-) A-I      intronic
chr1:57039745(-) A-I      intronic
chr1:57040091(-) A-I      intronic
chr1:57040180(-) A-I      intronic
chr1:57039680(-) A-I      intronic
chr1:57040201(-) A-I      intronic
chr1:57040155(-) A-I      intronic
chr1:57039681(-) A-I      intronic
chr1:57039690(-) A-I      intronic
chr1:57039701(-) A-I      intronic
chr1:57039707(-) A-I      intronic
chr1:57039725(-) A-I      intronic
chr1:57039729(-) A-I      intronic
chr1:57040141(-) A-I      intronic
chr1:57008545(-) A-I      intronic
chr1:56984441(-) A-I      intronic
chr1:56969934(-) A-I      intronic
chr1:56969717(-) A-I      intronic
chr1:56969711(-) A-I      intronic
chr1:57008546(-) A-I      intronic
chr1:56966494(-) A-I      intronic
chr1:57022504(-) A-I      intronic
chr1:56969662(-) A-I      intronic
chr1:56969560(-) A-I      intronic
chr1:56969559(-) A-I      intronic
chr1:56969217(-) A-I      intronic
chr1:56966576(-) A-I      intronic
chr1:57035117(-) A-I      intronic
chr1:57040174(-) A-I      intronic
chr1:57040131(-) A-I      intronic
chr1:57040104(-) A-I      intronic
chr1:57040103(-) A-I      intronic
chr1:57039870(-) A-I      intronic
chr1:57034983(-) A-I      intronic
chr1:57027584(-) A-I      intronic
chr1:57026649(-) A-I      intronic
chr1:57026648(-) A-I      intronic
chr1:57039630(-) A-I      intronic
chr1:57026622(-) A-I      intronic
chr1:57026573(-) A-I      intronic
chr1:57026558(-) A-I      intronic
chr1:57026541(-) A-I      intronic
chr1:57025204(-) A-I      intronic
chr1:57022551(-) A-I      intronic
chr1:57022512(-) A-I      intronic
chr1:57021428(-) A-I      intronic
chr1:57039851(-) A-I      intronic
chr1:57026563(-) A-I      intronic
chr1:57039618(-) A-I      intronic
chr1:57035124(-) A-I      intronic
chr1:57035118(-) A-I      intronic
chr1:57026639(-) A-I      intronic
chr1:57027541(-) A-I      intronic
chr1:56969261(-) A-I      intronic
chr1:57039710(-) A-I      intronic
chr1:57039842(-) A-I      intronic
chr1:57027672(-) A-I      intronic
chr1:57040066(-) A-I      intronic
chr1:57021456(-) A-I      intronic
chr1:56969663(-) A-I      intronic
chr1:57040200(-) A-I      intronic
chr1:57039834(-) A-I      intronic
chr1:56978049(-) A-I      ncRNA
chr1:56978092(-) A-I      ncRNA
chr1:56969212(-) A-I      intronic
chr1:56964484(-) A-I      intronic
chr1:56986301(-) A-I      intronic
chr1:57022474(-) A-I      intronic
chr1:57040234(-) A-I      intronic
chr1:56969556(-) A-I      intronic
chr1:56966432(-) A-I      intronic
chr1:56969338(-) A-I      intronic
chr1:56969703(-) A-I      intronic
chr1:57027442(-) A-I      intronic
chr1:57020032(-) A-I      intronic
chr1:57039685(-) A-I      intronic
chr1:56969554(-) A-I      intronic
chr1:56969634(-) A-I      intronic
chr1:56969482(-) A-I      intronic
chr1:57022531(-) A-I      intronic
chr1:56969118(-) A-I      intronic
chr1:57027586(-) A-I      intronic
chr1:57019989(-) A-I      intronic
chr1:56969117(-) A-I      intronic
chr1:56964483(-) A-I      intronic
chr1:57027542(-) A-I      intronic
chr1:56987320(-) A-I      intronic
chr1:57031367(-) A-I      intronic
chr1:56969954(-) A-I      intronic
chr1:56969116(-) A-I      intronic
chr1:57031383(-) A-I      intronic
chr1:57039749(-) A-I      intronic
chr1:57022477(-) A-I      intronic
chr1:57021401(-) A-I      intronic
chr1:57040020(-) A-I      intronic
chr1:57026792(-) A-I      intronic
chr1:56969619(-) A-I      intronic
chr1:57040127(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PLPP3
chr1:56962125-56962126(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr1:56962145-56962146(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr1:56962244-56962245(-) m6A CDS//exon       24981863//26404942//27773535//22608085
chr1:56962259-56962260(-) m6A CDS//exon       24981863//26404942//27773535//22608085
chr1:56962320-56962321(-) m6A CDS//exon       24209618//24981863//26404942//27773535
chr1:56977714-56977715(-) m6A CDS//exon       27773535
chr1:56977731-56977732(-) m6A CDS//exon       27773535
chr1:57002679-57002680(-) m6A CDS//exon       27773535
chr1:57002688-57002689(-) m6A CDS//exon       27773535
chr1:57002757-57002758(-) m6A CDS//exon       27773535
chr1:57044681-57044682(-) m6A CDS//intron       27773536
chr1:57044872-57044873(-) m6A 5'UTR//exon//intron       25456834//24981863//26404942//27371828//27773536//22608085
chr1:57044930-57044931(-) m6A 5'UTR//exon//intron       25456834//24981863//26404942//27371828//27773536//22608085
chr1:57045071-57045072(-) m6A 5'UTR//exon//intron       25456834//24981863//27773536//22608085
chr1:57045226-57045227(-) m6A 5'UTR//exon//intron       24981863
chr1:57045230-57045231(-) m6A 5'UTR//exon//intron       27773535
chr1:57109157-57109158(-) m6A exon//intron       27773535
chr1:57109209-57109210(-) m6A exon       27773535

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate PLPP3
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: PLPP3

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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