Basic Information:

  VIRBase ID:  

VHID00506885

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          GAS7:  NM_001130831     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	GAS7
miRBase Accession/Entrez ID	MIMAT0001581	8522
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	GAS7	chr17:9832859(-) A-I      intronic chr17:9832860(-) A-I      intronic chr17:9832900(-) A-I      intronic chr17:9832903(-) A-I      intronic chr17:10066643(-) A-I      intronic chr17:10066661(-) A-I      intronic chr17:10069469(-) A-I      intronic chr17:10069519(-) A-I      intronic chr17:9832888(-) A-I      intronic chr17:9817688(-) A-I      3'UTR chr17:10069520(-) A-I      intronic chr17:9817711(-) A-I      3'UTR chr17:10069536(-) A-I      intronic chr17:9832999(-) A-I      intronic chr17:9833015(-) A-I      intronic chr17:9836331(-) A-I      intronic chr17:9836437(-) A-I      intronic chr17:9836483(-) A-I      intronic chr17:9841661(-) A-I      intronic chr17:9841685(-) A-I      intronic chr17:9843097(-) A-I      intronic chr17:9843115(-) A-I      intronic chr17:9843120(-) A-I      intronic chr17:9849113(-) A-I      intronic chr17:9850978(-) A-I      intronic chr17:9850998(-) A-I      intronic chr17:9910819(-) A-I      intronic chr17:9853264(-) A-I      intronic chr17:9853356(-) A-I      intronic chr17:9853376(-) A-I      intronic chr17:9853448(-) A-I      intronic chr17:9853746(-) A-I      intronic chr17:9853777(-) A-I      intronic chr17:9853782(-) A-I      intronic chr17:9982249(-) A-I      intronic chr17:9853791(-) A-I      intronic chr17:9855072(-) A-I      intronic chr17:9981616(-) A-I      intronic chr17:9972067(-) A-I      intronic chr17:9873827(-) A-I      intronic chr17:9873866(-) A-I      intronic chr17:9873867(-) A-I      intronic chr17:9873897(-) A-I      intronic chr17:9878514(-) A-I      intronic chr17:9881995(-) A-I      intronic chr17:9884546(-) A-I      intronic chr17:9900021(-) A-I      intronic chr17:9900023(-) A-I      intronic chr17:9909684(-) A-I      intronic chr17:9909785(-) A-I      intronic chr17:9909880(-) A-I      intronic chr17:9909883(-) A-I      intronic chr17:9910776(-) A-I      intronic chr17:9910817(-) A-I      intronic chr17:9969560(-) A-I      intronic chr17:9913638(-) A-I      intronic chr17:9915876(-) A-I      intronic chr17:10041144(-) A-I      intronic chr17:9916176(-) A-I      intronic chr17:9916262(-) A-I      intronic chr17:9916308(-) A-I      intronic chr17:9919578(-) A-I      intronic chr17:9919580(-) A-I      intronic chr17:9919700(-) A-I      intronic chr17:9920365(-) A-I      intronic chr17:9920774(-) A-I      intronic chr17:9920919(-) A-I      intronic chr17:9951453(-) A-I      intronic chr17:9951471(-) A-I      intronic chr17:9953014(-) A-I      intronic chr17:9953043(-) A-I      intronic chr17:9953059(-) A-I      intronic chr17:9953066(-) A-I      intronic chr17:9953086(-) A-I      intronic chr17:9953106(-) A-I      intronic chr17:10041348(-) A-I      intronic chr17:10070507(-) A-I      intronic chr17:10070512(-) A-I      intronic chr17:10070513(-) A-I      intronic chr17:10071081(-) A-I      intronic chr17:10071187(-) A-I      intronic chr17:10077751(-) A-I      intronic chr17:10085681(-) A-I      intronic chr17:10085696(-) A-I      intronic chr17:10085704(-) A-I      intronic chr17:9953142(-) A-I      intronic chr17:9953188(-) A-I      intronic chr17:9953204(-) A-I      intronic chr17:9959944(-) A-I      intronic chr17:9960021(-) A-I      intronic chr17:9909795(-) A-I      intronic chr17:10013880(-) A-I      intronic chr17:10013888(-) A-I      intronic chr17:10070467(-) A-I      intronic chr17:10085741(-) A-I      intronic chr17:10085758(-) A-I      intronic chr17:10089433(-) A-I      intronic chr17:10092180(-) A-I      intronic chr17:10046375(-) A-I      intronic chr17:10052623(-) A-I      intronic chr17:10052670(-) A-I      intronic chr17:10070447(-) A-I      intronic chr17:10066645(-) A-I      intronic chr17:10066646(-) A-I      intronic chr17:10066667(-) A-I      intronic chr17:9996803(-) A-I      intronic chr17:9998057(-) A-I      intronic chr17:9998064(-) A-I      intronic chr17:9996707(-) A-I      intronic chr17:9996704(-) A-I      intronic chr17:9996699(-) A-I      intronic chr17:9996684(-) A-I      intronic chr17:9824647(-) A-I      intronic chr17:9824653(-) A-I      intronic chr17:10013927(-) A-I      intronic chr17:10032757(-) A-I      intronic chr17:10036719(-) A-I      intronic chr17:10069375(-) A-I      intronic chr17:10069387(-) A-I      intronic chr17:10069438(-) A-I      intronic chr17:10069462(-) A-I      intronic chr17:10069473(-) A-I      intronic chr17:10069497(-) A-I      intronic chr17:10069505(-) A-I      intronic chr17:10069544(-) A-I      intronic chr17:10069545(-) A-I      intronic chr17:10069554(-) A-I      intronic chr17:10069568(-) A-I      intronic chr17:10040319(-) A-I      intronic chr17:9825087(-) A-I      intronic chr17:9825213(-) A-I      intronic chr17:9832907(-) A-I      intronic chr17:9832929(-) A-I      intronic chr17:9832997(-) A-I      intronic chr17:9817724(-) A-I      3'UTR chr17:9843065(-) A-I      intronic chr17:10058469(-) A-I      intronic chr17:10023990(-) A-I      intronic chr17:10078311(-) A-I      intronic chr17:10065236(-) A-I      intronic chr17:9941614(-) A-I      intronic chr17:9996774(-) A-I      intronic chr17:9853384(-) A-I      intronic chr17:9941566(-) A-I      intronic chr17:10047985(-) A-I      intronic chr17:9826363(-) A-I      intronic chr17:9878564(-) A-I      intronic chr17:10089813(-) A-I      intronic chr17:9824473(-) A-I      intronic chr17:9920236(-) A-I      intronic chr17:10078327(-) A-I      intronic chr17:10047992(-) A-I      intronic chr17:10085614(-) A-I      intronic chr17:9981587(-) A-I      intronic chr17:10069573(-) A-I      intronic chr17:9836887(-) A-I      intronic chr17:10064064(-) A-I      intronic chr17:10078307(-) A-I      intronic chr17:9959565(-) A-I      intronic chr17:9830682(-) A-I      intronic chr17:10070982(-) A-I      intronic chr17:10036577(-) A-I      intronic chr17:9824582(-) A-I      intronic chr17:9873690(-) A-I      intronic chr17:10040286(-) A-I      intronic chr17:10057925(-) A-I      intronic chr17:9824602(-) A-I      intronic chr17:9843055(-) A-I      intronic chr17:9993302(-) A-I      intronic chr17:9953209(-) A-I      intronic chr17:9838190(-) A-I      intronic chr17:10066490(-) A-I      intronic chr17:9836914(-) A-I      intronic chr17:9827553(-) A-I      intronic chr17:9838095(-) A-I      intronic chr17:10057699(-) A-I      intronic chr17:10093737(-) A-I      intronic chr17:9824707(-) A-I      intronic chr17:9908170(-) A-I      intronic chr17:9941661(-) A-I      intronic chr17:9830680(-) A-I      intronic chr17:9878550(-) A-I      intronic chr17:9853581(-) A-I      intronic chr17:10066594(-) A-I      intronic chr17:10066689(-) A-I      intronic chr17:10069612(-) A-I      intronic chr17:9853652(-) A-I      intronic chr17:10036580(-) A-I      intronic chr17:9999005(-) A-I      intronic chr17:9853318(-) A-I      intronic chr17:10066608(-) A-I      intronic chr17:9837155(-) A-I      intronic chr17:10090196(-) A-I      intronic chr17:9824706(-) A-I      intronic chr17:9959555(-) A-I      intronic chr17:10066604(-) A-I      intronic chr17:10089400(-) A-I      intronic chr17:9835626(-) A-I      intronic chr17:10063441(-) A-I      intronic chr17:9833073(-) A-I      intronic chr17:9817746(-) A-I      3'UTR chr17:9853244(-) A-I      intronic chr17:10036078(-) A-I      intronic chr17:10051848(-) A-I      intronic chr17:9817675(-) A-I      3'UTR chr17:9999068(-) A-I      intronic chr17:9843105(-) A-I      intronic chr17:9982259(-) A-I      intronic chr17:9817721(-) A-I      3'UTR chr17:10078436(-) A-I      intronic chr17:10066531(-) A-I      intronic chr17:10063227(-) A-I      intronic chr17:9919455(-) A-I      intronic chr17:10066688(-) A-I      intronic chr17:9931680(-) A-I      intronic chr17:10052518(-) A-I      intronic chr17:9817649(-) A-I      3'UTR chr17:9850939(-) A-I      intronic chr17:9836389(-) A-I      intronic chr17:9853798(-) A-I      intronic chr17:10066513(-) A-I      intronic chr17:10040379(-) A-I      intronic chr17:9841782(-) A-I      intronic chr17:10092024(-) A-I      intronic chr17:9817708(-) A-I      3'UTR chr17:9999013(-) A-I      intronic chr17:9838248(-) A-I      intronic chr17:9824667(-) A-I      intronic chr17:9824651(-) A-I      intronic chr17:10069583(-) A-I      intronic chr17:10071288(-) A-I      intronic chr17:9824638(-) A-I      intronic chr17:10063170(-) A-I      intronic chr17:10078323(-) A-I      intronic chr17:10036028(-) A-I      intronic chr17:10091411(-) A-I      intronic chr17:10082390(-) A-I      intronic chr17:9886651(-) A-I      intronic chr17:9853341(-) A-I      intronic chr17:9915847(-) A-I      intronic chr17:10092080(-) A-I      intronic chr17:10065214(-) A-I      intronic chr17:9919446(-) A-I      intronic chr17:10071198(-) A-I      intronic chr17:10063495(-) A-I      intronic chr17:10086900(-) A-I      intronic chr17:9959690(-) A-I      intronic chr17:9817738(-) A-I      3'UTR chr17:10057613(-) A-I      intronic chr17:10034817(-) A-I      intronic chr17:9836322(-) A-I      intronic chr17:9835694(-) A-I      intronic chr17:9817777(-) A-I      3'UTR chr17:9876770(-) A-I      intronic chr17:10057814(-) A-I      intronic chr17:10092236(-) A-I      intronic chr17:9960024(-) A-I      intronic chr17:10036069(-) A-I      intronic chr17:10065337(-) A-I      intronic chr17:9843197(-) A-I      intronic chr17:9908083(-) A-I      intronic chr17:9824644(-) A-I      intronic chr17:9817611(-) A-I      3'UTR chr17:10084577(-) A-I      intronic chr17:9817816(-) A-I      3'UTR chr17:10065136(-) A-I      intronic chr17:9853707(-) A-I      intronic chr17:10066709(-) A-I      intronic chr17:9817612(-) A-I      3'UTR chr17:10071235(-) A-I      intronic chr17:9920913(-) A-I      intronic chr17:10069518(-) A-I      intronic chr17:10094669(-) A-I      intronic chr17:10044601(-) A-I      intronic chr17:9835728(-) A-I      intronic chr17:9841565(-) A-I      intronic chr17:10046416(-) A-I      intronic chr17:10058470(-) A-I      intronic chr17:10038427(-) A-I      intronic chr17:9817748(-) A-I      3'UTR chr17:9835597(-) A-I      intronic chr17:9851022(-) A-I      intronic chr17:9982456(-) A-I      intronic chr17:10061781(-) A-I      intronic chr17:10014056(-) A-I      intronic chr17:9900230(-) A-I      intronic chr17:9913639(-) A-I      intronic chr17:10092094(-) A-I      intronic chr17:9853319(-) A-I      intronic chr17:10069432(-) A-I      intronic chr17:10069344(-) A-I      intronic chr17:9827761(-) A-I      intronic chr17:9874787(-) A-I      intronic chr17:10066715(-) A-I      intronic chr17:9916295(-) A-I      intronic chr17:9835574(-) A-I      intronic chr17:10045941(-) A-I      intronic chr17:9950049(-) A-I      intronic chr17:10063241(-) A-I      intronic chr17:10078429(-) A-I      intronic chr17:10069540(-) A-I      intronic chr17:10069479(-) A-I      intronic chr17:10043568(-) A-I      intronic chr17:9920364(-) A-I      intronic chr17:10065192(-) A-I      intronic chr17:9878506(-) A-I      intronic chr17:10089560(-) A-I      intronic chr17:9910891(-) A-I      intronic chr17:10013879(-) A-I      intronic chr17:9951422(-) A-I      intronic chr17:9973856(-) A-I      intronic chr17:10078268(-) A-I      intronic chr17:10069437(-) A-I      intronic chr17:10070640(-) A-I      intronic chr17:9830765(-) A-I      intronic chr17:9909851(-) A-I      intronic chr17:10063188(-) A-I      intronic chr17:10078996(-) A-I      intronic chr17:9824656(-) A-I      intronic chr17:9982461(-) A-I      intronic chr17:9951633(-) A-I      intronic chr17:9997914(-) A-I      intronic chr17:9853580(-) A-I      intronic chr17:9998904(-) A-I      intronic chr17:9831558(-) A-I      intronic chr17:9830509(-) A-I      intronic chr17:10065297(-) A-I      intronic chr17:9830692(-) A-I      intronic chr17:10063235(-) A-I      intronic chr17:9915883(-) A-I      intronic chr17:9855976(-) A-I      intronic chr17:10047950(-) A-I      intronic chr17:9835608(-) A-I      intronic chr17:9827693(-) A-I      intronic chr17:10071289(-) A-I      intronic chr17:9971828(-) A-I      intronic chr17:9920849(-) A-I      intronic chr17:9825032(-) A-I      intronic chr17:9853761(-) A-I      intronic chr17:9855977(-) A-I      intronic chr17:10058447(-) A-I      intronic chr17:9920910(-) A-I      intronic chr17:9994735(-) A-I      intronic chr17:10094370(-) A-I      intronic chr17:9914917(-) A-I      intronic chr17:9843204(-) A-I      intronic chr17:10032680(-) A-I      intronic chr17:9830775(-) A-I      intronic chr17:9914814(-) A-I      intronic chr17:9942998(-) A-I      intronic chr17:9841641(-) A-I      intronic chr17:10041444(-) A-I      intronic chr17:9855411(-) A-I      intronic chr17:10040309(-) A-I      intronic chr17:9915860(-) A-I      intronic chr17:9915193(-) A-I      intronic chr17:10055000(-) A-I      intronic chr17:9836239(-) A-I      intronic chr17:10065587(-) A-I      intronic chr17:10063263(-) A-I      intronic chr17:10040283(-) A-I      intronic chr17:10076896(-) A-I      intronic chr17:10066655(-) A-I      intronic chr17:9843126(-) A-I      intronic chr17:10061707(-) A-I      intronic chr17:9830720(-) A-I      intronic chr17:9838217(-) A-I      intronic chr17:9914488(-) A-I      intronic chr17:10017370(-) A-I      intronic chr17:9878484(-) A-I      intronic chr17:9915707(-) A-I      intronic chr17:9834639(-) A-I      intronic chr17:10069508(-) A-I      intronic chr17:10078362(-) A-I      intronic chr17:10065338(-) A-I      intronic chr17:9855983(-) A-I      intronic chr17:9920784(-) A-I      intronic chr17:9942155(-) A-I      intronic chr17:9953076(-) A-I      intronic chr17:10063314(-) A-I      intronic chr17:10067966(-) A-I      intronic chr17:9843106(-) A-I      intronic chr17:10034768(-) A-I      intronic chr17:9853924(-) A-I      intronic chr17:10079103(-) A-I      intronic chr17:9854998(-) A-I      intronic chr17:9826341(-) A-I      intronic chr17:10066105(-) A-I      intronic chr17:10066670(-) A-I      intronic chr17:9984706(-) A-I      intronic chr17:9878665(-) A-I      intronic chr17:9915743(-) A-I      intronic chr17:10035977(-) A-I      intronic chr17:9853360(-) A-I      intronic chr17:10063200(-) A-I      intronic chr17:9953171(-) A-I      intronic chr17:10046465(-) A-I      intronic chr17:9817815(-) A-I      3'UTR chr17:9817682(-) A-I      3'UTR chr17:9817615(-) A-I      3'UTR chr17:9817574(-) A-I      3'UTR chr17:9817641(-) A-I      3'UTR

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	GAS7	chr17:10063170(-) A-I intron -    15342557 chr17:10063188(-) A-I intron -    15342557 chr17:10063200(-) A-I intron -    15342557 chr17:10063227(-) A-I intron -    15342557 chr17:10063235(-) A-I intron -    15342557 chr17:10063241(-) A-I intron -    15342557 chr17:10063263(-) A-I intron -    15342557 chr17:10063314(-) A-I intron -    15342557 chr17:10063495(-) A-I intron -    15342557 chr17:10064064(-) A-I intron -    15342557 chr17:10065136(-) A-I intron -    15342557 chr17:10065192(-) A-I intron -    15342557 chr17:10065214(-) A-I intron -    15342557 chr17:10065236(-) A-I intron -    15342557 chr17:10065297(-) A-I intron -    15342557 chr17:10065337(-) A-I intron -    15342557 chr17:10065338(-) A-I intron -    15342557 chr17:10065587(-) A-I intron -    15342557 chr17:10066105(-) A-I intron -    15342557 chr17:10066490(-) A-I intron -    15342557 chr17:10066513(-) A-I intron -    15342557 chr17:10066531(-) A-I intron -    15342557 chr17:10066594(-) A-I intron -    15342557 chr17:10066608(-) A-I intron -    15342557 chr17:10066670(-) A-I intron -    15342557 chr17:10066688(-) A-I intron -    15342557 chr17:10066689(-) A-I intron -    15342557 chr17:10066709(-) A-I intron -    15342557 chr17:10066715(-) A-I intron -    15342557 chr17:9817612(-) A-G exon 3'UTR    22484847 chr17:9817615(-) A-G exon 3'UTR    22484847 chr17:9817746(-) A-G exon 3'UTR    22484847 chr17:9817747(-) C-T exon 3'UTR    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	GAS7	chr17:10101848-10101849(-) m6A 5'UTR       27371828 chr17:9820264-9820265(-) m6A 3'UTR       27371828 chr17:9820280-9820281(-) m6A 3'UTR       27371828 chr17:9820316-9820317(-) m6A 3'UTR//CDS       25456834//27371828 chr17:9820354-9820355(-) m6A 3'UTR//intron       25456834//27371828 chr17:9820396-9820397(-) m6A 3'UTR//intron       25456834//27371828 chr17:9820557-9820558(-) m6A CDS//exon//intron       25456834//27371828 chr17:9820608-9820609(-) m6A CDS//exon//intron       25456834//27371828 chr17:9820620-9820621(-) m6A CDS//exon//intron       25456834//27371828 chr17:9821337-9821338(-) m6A CDS//exon//intron       25456834//27371828 chr17:9828039-9828040(-) m6A exon//intron       27371828 chr17:9828827-9828828(-) m6A CDS//exon//intron       27371828 chr17:9828837-9828838(-) m6A CDS//exon//intron       27371828 chr17:9828870-9828871(-) m6A CDS//exon//intron       27371828 chr17:9828884-9828885(-) m6A CDS//exon//intron       27371828 chr17:9830030-9830031(-) m6A CDS//exon//intron       27371828 chr17:9830042-9830043(-) m6A CDS//exon//intron       27371828 chr17:9850258-9850259(-) m6A CDS//exon//intron       - chr17:9850271-9850272(-) m6A CDS//exon//intron       - chr17:9850295-9850296(-) m6A CDS//exon//intron       - chr17:9862302-9862303(-) m6A exon//intron       - chr17:9862528-9862529(-) m6A CDS//exon//intron       - chr17:9862570-9862571(-) m6A CDS//exon//intron       - chr17:9862606-9862607(-) m6A CDS//intron       - chr17:9862641-9862642(-) m6A 5'UTR//intron       - chr17:9873034-9873035(-) m6A CDS//intron       - chr17:9873055-9873056(-) m6A CDS//intron       - chr17:9885198-9885199(-) m6A CDS//exon//intron       - chr17:9939913-9939914(-) m6A 5'UTR//exon//intron       -

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	GAS7	Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytoplasm Nasopharyngeal carcinoma cells     20498841 Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841 Nucleus Nasopharyngeal carcinoma cells     20498841

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: GAS7

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.