Basic Information:

  VIRBase ID:  

VHID00506882

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          IFITM1:  NM_003641     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	IFITM1
miRBase Accession/Entrez ID	MIMAT0001581	8519
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	9-27//CD225//DSPA2a//IFI17//LEU13

RNA Editing:

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	IFITM1	chr11:315267(+) T-C intron -    21725310

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	IFITM1	chr11:313992-313993(+) m6A 5'UTR//intron       25456834//24981863 chr11:314008-314009(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314036-314037(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314088-314089(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314120-314121(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314134-314135(+) m6A 5'UTR//intron       24284625//25456834//24981863 chr11:314184-314185(+) m6A CDS       24284625//25456834//24981863 chr11:314260-314261(+) m6A CDS       - chr11:314928-314929(+) m6A CDS//exon       24284625//24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	IFITM1	Chromatin K562 cells     - Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: IFITM1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.