Basic Information:

  VIRBase ID:  

VHID00506830

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          CUL4A:  NM_001008895     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	CUL4A
miRBase Accession/Entrez ID	MIMAT0001581	8451
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	CUL4A	chr13:113912579(+) A-I      intronic chr13:113875941(+) A-I      intronic chr13:113916175(+) A-I      intronic chr13:113890293(+) A-I      intronic chr13:113890296(+) A-I      intronic chr13:113890298(+) A-I      intronic chr13:113912558(+) A-I      intronic chr13:113890312(+) A-I      intronic chr13:113868929(+) A-I      intronic chr13:113890327(+) A-I      intronic chr13:113905913(+) A-I      intronic chr13:113912543(+) A-I      intronic chr13:113882072(+) A-I      intronic chr13:113896945(+) A-I      intronic chr13:113897020(+) A-I      intronic chr13:113896406(+) A-I      intronic chr13:113877015(+) A-I      intronic chr13:113877014(+) A-I      intronic chr13:113895909(+) A-I      intronic chr13:113895898(+) A-I      intronic chr13:113916260(+) A-I      intronic chr13:113876967(+) A-I      intronic chr13:113868901(+) A-I      intronic chr13:113896079(+) A-I      intronic chr13:113885270(+) A-I      intronic chr13:113872336(+) A-I      intronic chr13:113882113(+) A-I      intronic chr13:113882099(+) A-I      intronic chr13:113867525(+) A-I      intronic chr13:113866842(+) A-I      intronic chr13:113912510(+) A-I      intronic chr13:113877885(+) A-I      intronic chr13:113914265(+) A-I      intronic chr13:113896531(+) A-I      intronic chr13:113867511(+) A-I      intronic chr13:113865838(+) A-I      intronic chr13:113867455(+) A-I      intronic chr13:113878637(+) A-I      intronic chr13:113867452(+) A-I      intronic chr13:113912421(+) A-I      intronic chr13:113896934(+) A-I      intronic chr13:113867440(+) A-I      intronic chr13:113877878(+) A-I      intronic chr13:113878624(+) A-I      intronic chr13:113878546(+) A-I      intronic chr13:113878520(+) A-I      intronic chr13:113878509(+) A-I      intronic chr13:113878433(+) A-I      intronic chr13:113866984(+) A-I      intronic chr13:113878412(+) A-I      intronic chr13:113877848(+) A-I      intronic chr13:113866850(+) A-I      intronic chr13:113872295(+) A-I      intronic chr13:113877841(+) A-I      intronic chr13:113877838(+) A-I      intronic chr13:113914771(+) A-I      intronic chr13:113877811(+) A-I      intronic chr13:113914749(+) A-I      intronic chr13:113914632(+) A-I      intronic chr13:113877853(+) A-I      intronic chr13:113868902(+) A-I      intronic chr13:113914631(+) A-I      intronic chr13:113877184(+) A-I      intronic chr13:113912552(+) A-I      intronic chr13:113877110(+) A-I      intronic chr13:113912422(+) A-I      intronic chr13:113877753(+) A-I      intronic chr13:113896038(+) A-I      intronic chr13:113866872(+) A-I      intronic chr13:113868852(+) A-I      intronic chr13:113916688(+) A-I      intronic chr13:113877985(+) A-I      intronic chr13:113885309(+) A-I      intronic chr13:113878608(+) A-I      intronic chr13:113877068(+) A-I      intronic chr13:113901242(+) A-I      intronic chr13:113906096(+) A-I      intronic chr13:113914610(+) A-I      intronic chr13:113877851(+) A-I      intronic chr13:113914353(+) A-I      intronic chr13:113877116(+) A-I      intronic chr13:113877039(+) A-I      intronic chr13:113877812(+) A-I      intronic chr13:113868905(+) A-I      intronic chr13:113896430(+) A-I      intronic chr13:113896529(+) A-I      intronic chr13:113901353(+) A-I      intronic chr13:113896894(+) A-I      intronic chr13:113866825(+) A-I      intronic chr13:113877758(+) A-I      intronic chr13:113906021(+) A-I      intronic chr13:113868943(+) A-I      intronic chr13:113896937(+) A-I      intronic chr13:113865729(+) A-I      intronic chr13:113911513(+) A-I      intronic chr13:113882008(+) A-I      intronic chr13:113895929(+) A-I      intronic chr13:113897045(+) A-I      intronic chr13:113896375(+) A-I      intronic chr13:113865928(+) A-I      intronic chr13:113885116(+) A-I      intronic chr13:113911502(+) A-I      intronic chr13:113877766(+) A-I      intronic chr13:113896353(+) A-I      intronic chr13:113912401(+) A-I      intronic chr13:113883321(+) A-I      intronic chr13:113882236(+) A-I      intronic chr13:113896030(+) A-I      intronic chr13:113896948(+) A-I      intronic chr13:113877897(+) A-I      intronic chr13:113905866(+) A-I      intronic chr13:113877913(+) A-I      intronic chr13:113881965(+) A-I      intronic chr13:113901532(+) A-I      intronic chr13:113914713(+) A-I      intronic chr13:113916195(+) A-I      intronic chr13:113877829(+) A-I      intronic chr13:113866864(+) A-I      intronic chr13:113876971(+) A-I      intronic chr13:113901248(+) A-I      intronic chr13:113865973(+) A-I      intronic chr13:113916716(+) A-I      intronic chr13:113877773(+) A-I      intronic chr13:113916920(+) A-I      intronic chr13:113905833(+) A-I      intronic chr13:113865961(+) A-I      intronic chr13:113868903(+) A-I      intronic chr13:113912465(+) A-I      intronic chr13:113866847(+) A-I      intronic chr13:113877973(+) A-I      intronic chr13:113876021(+) A-I      intronic chr13:113866858(+) A-I      intronic chr13:113882172(+) A-I      intronic chr13:113877894(+) A-I      intronic chr13:113876965(+) A-I      intronic chr13:113878674(+) A-I      intronic chr13:113865981(+) A-I      intronic chr13:113865717(+) A-I      intronic chr13:113872405(+) A-I      intronic chr13:113901357(+) A-I      intronic chr13:113877155(+) A-I      intronic chr13:113881964(+) A-I      intronic chr13:113911368(+) A-I      intronic chr13:113865920(+) A-I      intronic chr13:113872429(+) A-I      intronic chr13:113896979(+) A-I      intronic chr13:113896398(+) A-I      intronic chr13:113896918(+) A-I      intronic chr13:113896490(+) A-I      intronic chr13:113914712(+) A-I      intronic chr13:113883415(+) A-I      intronic chr13:113866128(+) A-I      intronic chr13:113901241(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	CUL4A	chr13:113877829(+) A-I intron -    22327324 chr13:113876965(+) A-I intron -    21960545 chr13:113876971(+) A-I intron -    21960545 chr13:113877116(+) A-I intron -    21960545 chr13:113877753(+) A-I intron -    21960545 chr13:113877758(+) A-I intron -    21960545 chr13:113877766(+) A-I intron -    21960545 chr13:113881964(+) A-I intron -    21960545 chr13:113868852(+) A-I intron -    21960545 chr13:113901241(+) A-G intron -    22484847 chr13:113901242(+) A-G intron -    22484847 chr13:113901248(+) A-G intron -    22484847 chr13:113901357(+) A-G intron -    22484847 chr13:113901532(+) A-G intron -    22484847 chr13:113868852(+) A-G intron -    22484847 chr13:113877116(+) A-G intron -    22484847 chr13:113877155(+) A-G intron -    22484847 chr13:113877758(+) A-G intron -    22484847 chr13:113877812(+) A-G intron -    22484847 chr13:113877829(+) A-G intron -    22484847 chr13:113877851(+) A-G intron -    22484847 chr13:113877853(+) A-G intron -    22484847 chr13:113877885(+) A-G intron -    22484847 chr13:113896918(+) A-G intron -    22484847 chr13:113896945(+) A-G intron -    22484847 chr13:113896979(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CUL4A	chr13:113862788-113862789(+) m6A 5'UTR       25456834 chr13:113862801-113862802(+) m1A 5'UTR       26863196 chr13:113862853-113862854(+) m6A 5'UTR       24284625//25456834 chr13:113862862-113862863(+) m6A 5'UTR       24284625//25456834 chr13:113862906-113862907(+) m6A 5'UTR       24284625//25456834 chr13:113863092-113863093(+) m6A 5'UTR//intron       24284625 chr13:113864080-113864081(+) m6A CDS//exon//intron       24209618//22575960 chr13:113884005-113884006(+) m6A 3'UTR//exon//intron       25456834//22608085 chr13:113884051-113884052(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//22608085 chr13:113884083-113884084(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22608085 chr13:113884156-113884157(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr13:113884168-113884169(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr13:113884283-113884284(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863//22575960//22608085 chr13:113884337-113884338(+) m6A 3'UTR//exon//intron       24284625//24209618//25456834//24981863 chr13:113884425-113884426(+) m6A 3'UTR//intron       24284625//24209618 chr13:113897318-113897319(+) m6A CDS       - chr13:113897324-113897325(+) m6A CDS       - chr13:113897336-113897337(+) m6A CDS       - chr13:113897345-113897346(+) m6A CDS       - chr13:113897354-113897355(+) m6A CDS       - chr13:113897363-113897364(+) m6A CDS       - chr13:113897448-113897449(+) m6A CDS       24981863 chr13:113897466-113897467(+) m6A CDS       24981863 chr13:113898795-113898796(+) m6A CDS//exon       24981863 chr13:113909362-113909363(+) m6A CDS//exon       24981863 chr13:113909436-113909437(+) m6A CDS//exon       24981863 chr13:113914928-113914929(+) m6A CDS//intron       24981863 chr13:113914964-113914965(+) m6A CDS//intron       27773535 chr13:113915013-113915014(+) m6A CDS//intron       24284625//27773535//22608085 chr13:113917837-113917838(+) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr13:113917843-113917844(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr13:113917858-113917859(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr13:113917864-113917865(+) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr13:113917925-113917926(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr13:113917975-113917976(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr13:113917997-113917998(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr13:113918054-113918055(+) m6A 3'UTR       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr13:113918149-113918150(+) Gm 3'UTR       - chr13:113918157-113918158(+) m6A 3'UTR       24284625//24209618//24981863//22575960//22608085 chr13:113918267-113918268(+) m6A 3'UTR       24284625//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CUL4A	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|K562 cells     - Exosome Blood     - Membrane HCC cell line (HepG2)     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: CUL4A

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.