Detail Information

Basic Information:


  VIRBase ID:  

VHID00506613

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           BAG6:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p BAG6
miRBase
Accession/Entrez ID		 MIMAT0001581 7917
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - BAG-6//BAT3//D6S52E//G3

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR BAG6
chr6:31613849(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase BAG6
chr6:31606968-31606969(-) m6A CDS//exon       27773535
chr6:31607316-31607317(-) m6A CDS//exon//intron       27773535
chr6:31607553-31607554(-) m6A exon//intron       24284625
chr6:31608185-31608186(-) m6A CDS//exon//intron       27773536//22575960
chr6:31608190-31608191(-) m6A CDS//exon//intron       27773536//22575960
chr6:31608212-31608213(-) m6A CDS//exon//intron       27773536//22575960
chr6:31608277-31608278(-) m6A CDS//exon//intron       27773536//22575960
chr6:31608895-31608896(-) Y CDS//exon       26075521
chr6:31609685-31609686(-) m6A CDS//exon       27773535
chr6:31610035-31610036(-) Y CDS//exon       26075521
chr6:31610170-31610171(-) m6A CDS//exon//intron       27773535
chr6:31610883-31610884(-) m6A CDS//exon       24284625//22575960
chr6:31611863-31611864(-) m6A CDS//exon//intron       24284625//22575960
chr6:31611969-31611970(-) m6A CDS//exon//intron       24284625
chr6:31612307-31612308(-) m6A CDS//exon//intron       24284625//27773536
chr6:31612326-31612327(-) m6A CDS//exon//intron       24284625//27773535//27773536
chr6:31612730-31612731(-) m6A CDS//exon       24284625//27773535//22575960
chr6:31612753-31612754(-) m6A CDS//exon       24284625//27773535//22575960
chr6:31612935-31612936(-) m6A CDS//exon       24284625//27773535//22575960
chr6:31612962-31612963(-) m6A CDS//exon       24284625//27773535//22575960
chr6:31614183-31614184(-) m6A CDS       24284625//27773535//22575960
chr6:31615380-31615381(-) m6A CDS       24284625//24981863//27773535//27773536//22575960
chr6:31615433-31615434(-) m6A CDS       24284625//24981863//28052920//27773535//27773536//22575960
chr6:31615507-31615508(-) m6A CDS       24284625//24981863//27773535//22575960
chr6:31615515-31615516(-) m6A CDS       24284625//24981863//27773535//22575960
chr6:31616473-31616474(-) m6A CDS       24284625//27773535
chr6:31616702-31616703(-) m6A CDS//intron       24284625
chr6:31616989-31616990(-) m6A CDS       24284625
chr6:31619458-31619459(-) m6A CDS       24284625
chr6:31619466-31619467(-) m6A CDS       24284625
chr6:31619473-31619474(-) m6A CDS       24284625//22575960
chr6:31619550-31619551(-) m6A 5'UTR       24284625//22575960
chr6:31619650-31619651(-) m6A 5'UTR//intron       24284625
chr6:31619681-31619682(-) m6A 5'UTR//intron       24981863
chr6:31620188-31620189(-) m6A 5'UTR//intron       24284625
chr6:31620275-31620276(-) m6A 5'UTR//intron       24284625//24981863//22575960
chr6:31620312-31620313(-) m6A 5'UTR       24284625//24981863//22575960
chr6:31620333-31620334(-) m6A 5'UTR       24284625//24981863//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate BAG6
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: BAG6

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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