Detail Information

Basic Information:


  VIRBase ID:  

VHID00506610

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           DEK:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p DEK
miRBase
Accession/Entrez ID		 MIMAT0001581 7913
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - D6S231E

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR DEK
chr6:18238342(-) A-I      intronic
chr6:18250954(-) A-I      intronic
chr6:18257946(-) A-I      intronic
chr6:18257725(-) A-I      intronic
chr6:18238211(-) A-I      intronic
chr6:18238247(-) A-I      intronic
chr6:18254041(-) A-I      intronic
chr6:18254052(-) A-I      intronic
chr6:18238796(-) A-I      intronic
chr6:18238296(-) A-I      intronic
chr6:18238657(-) A-I      intronic
chr6:18238667(-) A-I      intronic
chr6:18254059(-) A-I      intronic
chr6:18254076(-) A-I      intronic
chr6:18238725(-) A-I      intronic
chr6:18238760(-) A-I      intronic
chr6:18254081(-) A-I      intronic
chr6:18238804(-) A-I      intronic
chr6:18238806(-) A-I      intronic
chr6:18238811(-) A-I      intronic
chr6:18238828(-) A-I      intronic
chr6:18239253(-) A-I      intronic
chr6:18239258(-) A-I      intronic
chr6:18239279(-) A-I      intronic
chr6:18240942(-) A-I      intronic
chr6:18240970(-) A-I      intronic
chr6:18242549(-) A-I      intronic
chr6:18250533(-) A-I      intronic
chr6:18250536(-) A-I      intronic
chr6:18238196(-) A-I      intronic
chr6:18238273(-) A-I      intronic
chr6:18254220(-) A-I      intronic
chr6:18254443(-) A-I      intronic
chr6:18254104(-) A-I      intronic
chr6:18238865(-) A-I      intronic
chr6:18241015(-) A-I      intronic
chr6:18242591(-) A-I      intronic
chr6:18238267(-) A-I      intronic
chr6:18239333(-) A-I      intronic
chr6:18238771(-) A-I      intronic
chr6:18239660(-) A-I      intronic
chr6:18238237(-) A-I      intronic
chr6:18256225(-) A-I      intronic
chr6:18238238(-) A-I      intronic
chr6:18241021(-) A-I      intronic
chr6:18257794(-) A-I      intronic
chr6:18238270(-) A-I      intronic
chr6:18238673(-) A-I      intronic
chr6:18226780(-) A-I      intronic
chr6:18238169(-) A-I      intronic
chr6:18238762(-) A-I      intronic
chr6:18250905(-) A-I      intronic
chr6:18250906(-) A-I      intronic
chr6:18248176(-) A-I      intronic
chr6:18242482(-) A-I      intronic
chr6:18239413(-) A-I      intronic
chr6:18238748(-) A-I      intronic
chr6:18238853(-) A-I      intronic
chr6:18248008(-) A-I      intronic
chr6:18238373(-) A-I      intronic
chr6:18238367(-) A-I      intronic
chr6:18226845(-) A-I      intronic
chr6:18239293(-) A-I      intronic
chr6:18238845(-) A-I      intronic
chr6:18250909(-) A-I      intronic
chr6:18239444(-) A-I      intronic
chr6:18226753(-) A-I      intronic
chr6:18226806(-) A-I      intronic
chr6:18238327(-) A-I      intronic
chr6:18250897(-) A-I      intronic
chr6:18238264(-) A-I      intronic
chr6:18240944(-) A-I      intronic
chr6:18242507(-) A-I      intronic
chr6:18239294(-) A-I      intronic
chr6:18254207(-) A-I      intronic
chr6:18252484(-) A-I      intronic
chr6:18238846(-) A-I      intronic
chr6:18254206(-) A-I      intronic
chr6:18242587(-) A-I      intronic
chr6:18250511(-) A-I      intronic
chr6:18235939(-) A-I      intronic
chr6:18226839(-) A-I      intronic
chr6:18248032(-) A-I      intronic
chr6:18238756(-) A-I      intronic
chr6:18238859(-) A-I      intronic
chr6:18254455(-) A-I      intronic
chr6:18238816(-) A-I      intronic
chr6:18238356(-) A-I      intronic
chr6:18254092(-) A-I      intronic
chr6:18254370(-) A-I      intronic
chr6:18253991(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED DEK
chr6:18253404(-) A-G intron -    22484847
chr6:18238195(-) A-G intron -    22484847
chr6:18238327(-) A-G intron -    22484847
chr6:18238356(-) A-G intron -    22484847
chr6:18238367(-) A-G intron -    22484847
chr6:18238705(-) C-T intron -    22484847
chr6:18238756(-) A-G intron -    22484847
chr6:18238762(-) A-G intron -    22484847
chr6:18238765(-) A-G intron -    22484847
chr6:18238771(-) A-G intron -    22484847
chr6:18238816(-) A-G intron -    22484847
chr6:18238841(-) A-G intron -    22484847
chr6:18238842(-) A-G intron -    22484847
chr6:18238845(-) A-G intron -    22484847
chr6:18238846(-) A-G intron -    22484847
chr6:18239293(-) A-G intron -    22484847
chr6:18239294(-) A-G intron -    22484847
chr6:18239413(-) A-G intron -    22484847
chr6:18242507(-) A-G intron -    22484847
chr6:18248008(-) A-G intron -    22484847
chr6:18250511(-) A-G intron -    22484847
chr6:18253991(-) A-G intron -    22484847
chr6:18254206(-) A-G intron -    22484847
chr6:18254370(-) A-G intron -    22484847
chr6:18254450(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase DEK
chr6:18224868-18224869(-) Gm 3'UTR       -
chr6:18224957-18224958(-) m6A 3'UTR       22575960
chr6:18225010-18225011(-) m6A 3'UTR       24981863//26404942//22575960
chr6:18225063-18225064(-) m6A 3'UTR       24981863//26404942//22575960
chr6:18225097-18225098(-) m6A 3'UTR       24981863//26404942
chr6:18225193-18225194(-) m6A 3'UTR       22575960
chr6:18225231-18225232(-) m6A 3'UTR       22575960
chr6:18225244-18225245(-) m6A 3'UTR       22575960
chr6:18225270-18225271(-) m6A 3'UTR       22575960
chr6:18225917-18225918(-) Tm 3'UTR       -
chr6:18225940-18225941(-) m6A 3'UTR       24981863//26404942//27773535
chr6:18226200-18226201(-) m6A 3'UTR//intron       27773535
chr6:18226206-18226207(-) m6A 3'UTR//intron       27773535
chr6:18226361-18226362(-) m6A 3'UTR//intron       24981863
chr6:18226418-18226419(-) m6A CDS       24981863//27773535
chr6:18236697-18236698(-) m6A CDS       24981863//28052920//27773535//22575960//22608085
chr6:18236747-18236748(-) m6A 3'UTR//CDS       24981863//28052920//27773535//22575960//22608085
chr6:18236775-18236776(-) m6A 3'UTR//CDS       24284625//24981863//28052920//27773535//22575960//22608085
chr6:18236799-18236800(-) m6A 3'UTR//CDS       24284625//24981863//28052920//27773535//22575960//22608085
chr6:18237367-18237368(-) m6A exon//intron       24284625//24981863//28052920//27773535//22608085
chr6:18237378-18237379(-) m6A exon//intron       24284625//24981863//28052920//27773535//22608085
chr6:18237406-18237407(-) m6A exon//intron       24981863//28052920//27773535//22608085
chr6:18237625-18237626(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535//22575960//22608085
chr6:18237711-18237712(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535//22575960//22608085
chr6:18237717-18237718(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535//22575960//22608085
chr6:18237734-18237735(-) m6A 3'UTR//CDS//exon       24981863//28052920//27773535//22575960//22608085
chr6:18244774-18244775(-) m6A CDS//intron       24981863//27773535//22608085
chr6:18244812-18244813(-) m6A CDS//intron       24981863//27773535
chr6:18249893-18249894(-) Am CDS//exon       -
chr6:18249927-18249928(-) m6A CDS//exon       24981863
chr6:18249985-18249986(-) m6A CDS//exon       24981863
chr6:18250017-18250018(-) m6A CDS//exon       24981863
chr6:18250048-18250049(-) m6A CDS//exon       24981863
chr6:18256012-18256013(-) m6A CDS//exon       22575960
chr6:18258207-18258208(-) m6A CDS       24981863//27773535
chr6:18258225-18258226(-) m6A CDS       24981863//27773535
chr6:18258233-18258234(-) m6A CDS       24981863//27773535
chr6:18258279-18258280(-) m6A CDS//intron       24209618//24981863//28052920//27773535//27371828
chr6:18264134-18264135(-) Cm CDS//intron       -
chr6:18264152-18264153(-) m6A CDS//intron       24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960
chr6:18264181-18264182(-) m6A CDS//intron       24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960
chr6:18264258-18264259(-) m6A 5'UTR//intron       24209618//25456834//24981863//27371828//27773536//22575960
chr6:18264371-18264372(-) m6A 5'UTR//intron       24209618//24981863//27773536//22575960
chr6:18264662-18264663(-) m6A 5'UTR       24209618//24981863//27371828//27773536//22575960
chr6:18264713-18264714(-) m6A 5'UTR       24209618//24981863//27371828//27773536//22575960
chr6:18264749-18264750(-) Y 5'UTR       25219674
chr6:18264777-18264778(-) m6A 5'UTR       24209618//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate DEK
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: DEK

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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