Detail Information

Basic Information:


  VIRBase ID:  

VHID00506609

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           REEP5:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p REEP5
miRBase
Accession/Entrez ID		 MIMAT0001581 7905
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - C5orf18//D5S346//DP1//POB16//TB2//Yip2e//YOP1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR REEP5
chr5:112236582(-) A-I      intronic
chr5:112236606(-) A-I      intronic
chr5:112255136(-) A-I      intronic
chr5:112225911(-) A-I      intronic
chr5:112255133(-) A-I      intronic
chr5:112255082(-) A-I      intronic
chr5:112255057(-) A-I      intronic
chr5:112255010(-) A-I      intronic
chr5:112252886(-) A-I      intronic
chr5:112249817(-) A-I      intronic
chr5:112249793(-) A-I      intronic
chr5:112249771(-) A-I      intronic
chr5:112249739(-) A-I      intronic
chr5:112249707(-) A-I      intronic
chr5:112249704(-) A-I      intronic
chr5:112249685(-) A-I      intronic
chr5:112241495(-) A-I      intronic
chr5:112241446(-) A-I      intronic
chr5:112237603(-) A-I      intronic
chr5:112237548(-) A-I      intronic
chr5:112237512(-) A-I      intronic
chr5:112217720(-) A-I      intronic
chr5:112236620(-) A-I      intronic
chr5:112236646(-) A-I      intronic
chr5:112217559(-) A-I      intronic
chr5:112241415(-) A-I      intronic
chr5:112217748(-) A-I      intronic
chr5:112217763(-) A-I      intronic
chr5:112225443(-) A-I      intronic
chr5:112225482(-) A-I      intronic
chr5:112225487(-) A-I      intronic
chr5:112225491(-) A-I      intronic
chr5:112225562(-) A-I      intronic
chr5:112225870(-) A-I      intronic
chr5:112236817(-) A-I      intronic
chr5:112226908(-) A-I      intronic
chr5:112226921(-) A-I      intronic
chr5:112226934(-) A-I      intronic
chr5:112226937(-) A-I      intronic
chr5:112226938(-) A-I      intronic
chr5:112226952(-) A-I      intronic
chr5:112236632(-) A-I      intronic
chr5:112236685(-) A-I      intronic
chr5:112217701(-) A-I      intronic
chr5:112237188(-) A-I      intronic
chr5:112225961(-) A-I      intronic
chr5:112226154(-) A-I      intronic
chr5:112226158(-) A-I      intronic
chr5:112226239(-) A-I      intronic
chr5:112226252(-) A-I      intronic
chr5:112226334(-) A-I      intronic
chr5:112226347(-) A-I      intronic
chr5:112226356(-) A-I      intronic
chr5:112236570(-) A-I      intronic
chr5:112225904(-) A-I      intronic
chr5:112225905(-) A-I      intronic
chr5:112213701(-) A-I      3'UTR
chr5:112213713(-) A-I      3'UTR
chr5:112213705(-) A-I      3'UTR
chr5:112213709(-) A-I      3'UTR
chr5:112213707(-) A-I      3'UTR
chr5:112213703(-) A-I      3'UTR
chr5:112213715(-) A-I      3'UTR
chr5:112213683(-) A-I      3'UTR
chr5:112229809(-) A-I      intronic
chr5:112236595(-) A-I      intronic
chr5:112225910(-) A-I      intronic
chr5:112245947(-) A-I      intronic
chr5:112216743(-) A-I      intronic
chr5:112229940(-) A-I      intronic
chr5:112230071(-) A-I      intronic
chr5:112229984(-) A-I      intronic
chr5:112228983(-) A-I      intronic
chr5:112245852(-) A-I      intronic
chr5:112235088(-) A-I      intronic
chr5:112228862(-) A-I      intronic
chr5:112245755(-) A-I      intronic
chr5:112245834(-) A-I      intronic
chr5:112229919(-) A-I      intronic
chr5:112244454(-) A-I      intronic
chr5:112237327(-) A-I      intronic
chr5:112236666(-) A-I      intronic
chr5:112236672(-) A-I      intronic
chr5:112229024(-) A-I      intronic
chr5:112237149(-) A-I      intronic
chr5:112236831(-) A-I      intronic
chr5:112249837(-) A-I      intronic
chr5:112230671(-) A-I      intronic
chr5:112236658(-) A-I      intronic
chr5:112249763(-) A-I      intronic
chr5:112236808(-) A-I      intronic
chr5:112236778(-) A-I      intronic
chr5:112249801(-) A-I      intronic
chr5:112225688(-) A-I      intronic
chr5:112232528(-) A-I      intronic
chr5:112235093(-) A-I      intronic
chr5:112249998(-) A-I      intronic
chr5:112233512(-) A-I      intronic
chr5:112230033(-) A-I      intronic
chr5:112237287(-) A-I      intronic
chr5:112244042(-) A-I      intronic
chr5:112232137(-) A-I      intronic
chr5:112230063(-) A-I      intronic
chr5:112237309(-) A-I      intronic
chr5:112236577(-) A-I      intronic
chr5:112216718(-) A-I      intronic
chr5:112244431(-) A-I      intronic
chr5:112235104(-) A-I      intronic
chr5:112237629(-) A-I      intronic
chr5:112244426(-) A-I      intronic
chr5:112233511(-) A-I      intronic
chr5:112236809(-) A-I      intronic
chr5:112229955(-) A-I      intronic
chr5:112232157(-) A-I      intronic
chr5:112236714(-) A-I      intronic
chr5:112229025(-) A-I      intronic
chr5:112245837(-) A-I      intronic
chr5:112249221(-) A-I      intronic
chr5:112245917(-) A-I      intronic
chr5:112244296(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED REEP5
chr5:112227556(-) A-I intron -    22327324
chr5:112227582(-) A-I intron -    22327324
chr5:112227585(-) A-I intron -    22327324
chr5:112227650(-) A-I intron -    22327324
chr5:112227789(-) A-I intron -    22327324
chr5:112227792(-) A-I intron -    22327324
chr5:112227906(-) A-I intron -    22327324
chr5:112228245(-) A-I intron -    22327324
chr5:112228323(-) A-I intron -    22327324
chr5:112229089(-) A-I intron -    22327324
chr5:112230073(-) A-I intron -    22327324
chr5:112230694(-) A-I intron -    22327324
chr5:112228865(-) T-C intron -    22484847
chr5:112229024(-) A-G intron -    22484847
chr5:112229025(-) A-G intron -    22484847
chr5:112229027(-) T-C intron -    22484847
chr5:112229028(-) T-C intron -    22484847
chr5:112229089(-) T-C intron -    22484847
chr5:112229919(-) A-G intron -    22484847
chr5:112230059(-) T-C intron -    22484847
chr5:112230073(-) T-C intron -    22484847
chr5:112230694(-) T-C intron -    22484847
chr5:112230707(-) T-C intron -    22484847
chr5:112232201(-) T-C intron -    22484847
chr5:112232507(-) T-C intron -    22484847
chr5:112232565(-) T-C intron -    22484847
chr5:112233511(-) A-G intron -    22484847
chr5:112233635(-) T-C intron -    22484847
chr5:112233636(-) T-C intron -    22484847
chr5:112235039(-) T-C intron -    22484847
chr5:112236538(-) G-A intron -    22484847
chr5:112236577(-) A-G intron -    22484847
chr5:112236595(-) A-G intron -    22484847
chr5:112236658(-) A-G intron -    22484847
chr5:112236714(-) A-G intron -    22484847
chr5:112236778(-) A-G intron -    22484847
chr5:112236808(-) A-G intron -    22484847
chr5:112236809(-) A-G intron -    22484847
chr5:112237223(-) A-G intron -    22484847
chr5:112237287(-) A-G intron -    22484847
chr5:112237309(-) A-G intron -    22484847
chr5:112237326(-) A-G intron -    22484847
chr5:112237551(-) A-G intron -    22484847
chr5:112237560(-) A-G intron -    22484847
chr5:112237573(-) A-G intron -    22484847
chr5:112237616(-) A-G intron -    22484847
chr5:112237629(-) A-G intron -    22484847
chr5:112237667(-) C-T intron -    22484847
chr5:112237915(-) C-A intron -    22484847
chr5:112244437(-) T-C intron -    22484847
chr5:112245947(-) A-G intron -    22484847
chr5:112248830(-) T-C intron -    22484847
chr5:112249703(-) A-G intron -    22484847
chr5:112249763(-) A-G intron -    22484847
chr5:112249801(-) A-G intron -    22484847
chr5:112249837(-) A-G intron -    22484847
chr5:112250098(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase REEP5
chr5:112213850-112213851(-) m6A 3'UTR//exon       27773535
chr5:112213914-112213915(-) m6A 3'UTR//exon       27773535
chr5:112213937-112213938(-) m6A 3'UTR//exon       27773535
chr5:112214377-112214378(-) m6A 3'UTR//exon       -
chr5:112214414-112214415(-) m6A 3'UTR//exon       -
chr5:112214465-112214466(-) m6A 3'UTR//exon       24981863//28052920//22575960
chr5:112214476-112214477(-) m6A 3'UTR//exon       24981863//28052920//22575960
chr5:112214481-112214482(-) m6A 3'UTR//exon       24981863//28052920//26404942//22575960
chr5:112214501-112214502(-) Am 3'UTR//CDS//exon       -
chr5:112222735-112222736(-) m6A 3'UTR//CDS//exon//intron       24981863//28052920//26404942//22575960
chr5:112222749-112222750(-) m6A 3'UTR//CDS//exon//intron       24981863//26404942
chr5:112222758-112222759(-) m6A 3'UTR//CDS//exon//intron       24981863//26404942
chr5:112222773-112222774(-) m6A 3'UTR//CDS//exon//intron       24981863//26404942
chr5:112222829-112222830(-) m6A 3'UTR//CDS//exon//intron       24981863
chr5:112228289-112228290(-) m6A 3'UTR//exon//intron       24981863
chr5:112228310-112228311(-) m6A 3'UTR//exon//intron       24981863
chr5:112228344-112228345(-) m6A 3'UTR//exon//intron       24284625//24981863//22608085
chr5:112228395-112228396(-) m6A 3'UTR//exon//intron       24284625//24981863//22608085
chr5:112228502-112228503(-) m6A CDS//exon//intron       24284625
chr5:112256942-112256943(-) m6A CDS//exon       27371828
chr5:112257050-112257051(-) m6A exon//intron       27371828
chr5:112257653-112257654(-) m6A 5'UTR//intron       24981863//27371828//27773536//22608085
chr5:112257662-112257663(-) m6A 5'UTR//intron       24981863//27371828//27773536//22608085
chr5:112257685-112257686(-) m6A 5'UTR//intron       24284625//25456834//24981863//27371828//27773536//22608085
chr5:112257789-112257790(-) m6A CDS       24284625//25456834//24981863//26404942//27371828//27773536//22575960//22608085
chr5:112257799-112257800(-) m6A CDS       24284625//25456834//24981863//26404942//27371828//27773536//22575960//22608085
chr5:112257837-112257838(-) m6A CDS       24284625//25456834//24981863//26404942//27371828//27773536//22575960//22608085
chr5:112257916-112257917(-) m6A 5'UTR//CDS       24284625//25456834//24981863//26404942//27371828//27773536//22575960//22608085
chr5:112258153-112258154(-) m6A 5'UTR       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate REEP5
Chromatin K562 cells     -
Cytosol K562 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: REEP5

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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