Basic Information:

  VIRBase ID:  

VHID00506595

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          CXCR4:  NM_001348059     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	CXCR4
miRBase Accession/Entrez ID	MIMAT0001581	7852
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	CD184//D2S201E//FB22//HM89//HSY3RR//LAP-3//LAP3//LCR1//LESTR//NPY3R//NPYR//NPYRL//NPYY3R//WHIM//WHIMS

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	CXCR4	chr2:136872173-136872174(-) m6A 3'UTR       24284625//26404942 chr2:136872178-136872179(-) m6A 3'UTR       24284625//26404942 chr2:136872193-136872194(-) m6A 3'UTR       24284625//26404942 chr2:136872235-136872236(-) m6A 3'UTR//exon       24284625//26404942 chr2:136872364-136872365(-) m6A 3'UTR//exon       24284625//26404942//27773535 chr2:136872423-136872424(-) m6A 3'UTR//exon       24284625//25456834//24981863//26404942//27773535//27371828//22608085 chr2:136872489-136872490(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//22575960//22608085 chr2:136872566-136872567(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//22575960//22608085 chr2:136872604-136872605(-) m6A CDS//exon       24284625//24981863//26404942//27773535//27371828//22575960//22608085 chr2:136872664-136872665(-) m6A CDS//exon       24284625//24981863//26404942//27773535//22575960//22608085 chr2:136872779-136872780(-) m6A CDS//exon       24284625//24981863//27773535//22575960//22608085 chr2:136873099-136873100(-) m6A CDS//exon       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr2:136873180-136873181(-) m6A CDS//exon       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr2:136873195-136873196(-) m6A CDS//exon       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr2:136873276-136873277(-) m6A CDS//exon       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr2:136873293-136873294(-) m6A CDS//exon       24284625//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr2:136873419-136873420(-) m6A CDS//exon       24284625//24981863//28052920//27773535//27371828//22575960//22608085 chr2:136873438-136873439(-) m6A CDS//exon       24284625//24981863//27773535//27371828//22575960//22608085 chr2:136875257-136875258(-) m6A exon//intron       24284625 chr2:136875263-136875264(-) m6A exon//intron       24284625 chr2:136875642-136875643(-) m6A 5'UTR       24284625//24981863//27371828 chr2:136875723-136875724(-) m6A 5'UTR       24284625//24981863//27371828

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	CXCR4	Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HeLa-S3 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: CXCR4

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.