Detail Information

Basic Information:


  VIRBase ID:  

VHID00506536

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           TRIM26:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p TRIM26
miRBase
Accession/Entrez ID		 MIMAT0001581 7726
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - AFP//RNF95//ZNF173

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TRIM26
chr6:30167686(-) A-I      intronic
chr6:30162508(-) A-I      intronic
chr6:30169441(-) A-I      intronic
chr6:30169497(-) A-I      intronic
chr6:30167618(-) A-I      intronic
chr6:30167546(-) A-I      intronic
chr6:30167510(-) A-I      intronic
chr6:30162669(-) A-I      intronic
chr6:30162647(-) A-I      intronic
chr6:30162550(-) A-I      intronic
chr6:30162532(-) A-I      intronic
chr6:30162520(-) A-I      intronic
chr6:30162497(-) A-I      intronic
chr6:30160435(-) A-I      intronic
chr6:30160428(-) A-I      intronic
chr6:30160412(-) A-I      intronic
chr6:30171331(-) A-I      intronic
chr6:30177580(-) A-I      intronic
chr6:30173427(-) A-I      intronic
chr6:30173394(-) A-I      intronic
chr6:30171461(-) A-I      intronic
chr6:30171445(-) A-I      intronic
chr6:30171444(-) A-I      intronic
chr6:30171398(-) A-I      intronic
chr6:30171397(-) A-I      intronic
chr6:30171389(-) A-I      intronic
chr6:30171388(-) A-I      intronic
chr6:30171387(-) A-I      intronic
chr6:30171357(-) A-I      intronic
chr6:30171318(-) A-I      intronic
chr6:30171282(-) A-I      intronic
chr6:30171220(-) A-I      intronic
chr6:30170897(-) A-I      intronic
chr6:30169586(-) A-I      intronic
chr6:30169568(-) A-I      intronic
chr6:30167983(-) A-I      intronic
chr6:30167868(-) A-I      intronic
chr6:30162484(-) A-I      intronic
chr6:30160431(-) A-I      intronic
chr6:30161129(-) A-I      intronic
chr6:30172815(-) A-I      intronic
chr6:30168009(-) A-I      intronic
chr6:30168053(-) A-I      intronic
chr6:30167609(-) A-I      intronic
chr6:30173380(-) A-I      intronic
chr6:30167959(-) A-I      intronic
chr6:30170949(-) A-I      intronic
chr6:30167680(-) A-I      intronic
chr6:30167865(-) A-I      intronic
chr6:30170893(-) A-I      intronic
chr6:30171095(-) A-I      intronic
chr6:30169509(-) A-I      intronic
chr6:30160330(-) A-I      intronic
chr6:30167876(-) A-I      intronic
chr6:30167447(-) A-I      intronic
chr6:30170928(-) A-I      intronic
chr6:30170989(-) A-I      intronic
chr6:30170888(-) A-I      intronic
chr6:30162671(-) A-I      intronic
chr6:30177834(-) A-I      intronic
chr6:30169581(-) A-I      intronic
chr6:30170918(-) A-I      intronic
chr6:30170980(-) A-I      intronic
chr6:30173398(-) A-I      intronic
chr6:30168018(-) A-I      intronic
chr6:30167804(-) A-I      intronic
chr6:30169499(-) A-I      intronic
chr6:30168045(-) A-I      intronic
chr6:30167552(-) A-I      intronic
chr6:30171330(-) A-I      intronic
chr6:30171467(-) A-I      intronic
chr6:30161044(-) A-I      intronic
chr6:30168012(-) A-I      intronic
chr6:30169379(-) A-I      intronic
chr6:30167947(-) A-I      intronic
chr6:30170856(-) A-I      intronic
chr6:30170988(-) A-I      intronic
chr6:30171602(-) A-I      intronic
chr6:30161183(-) A-I      intronic
chr6:30167669(-) A-I      intronic
chr6:30171097(-) A-I      intronic
chr6:30167813(-) A-I      intronic
chr6:30169433(-) A-I      intronic
chr6:30168002(-) A-I      intronic
chr6:30162492(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TRIM26
chr6:30152244-30152245(-) m6A 3'UTR//exon       27773535
chr6:30152459-30152460(-) m6A 3'UTR//exon       24284625//24981863//28052920//27773535//22608085
chr6:30152614-30152615(-) m6A 3'UTR//exon       24284625//24981863//27773535
chr6:30152701-30152702(-) m6A 3'UTR//exon       24284625//27773535
chr6:30152815-30152816(-) m6A 3'UTR//exon       24284625
chr6:30152836-30152837(-) m6A 3'UTR//exon       24284625
chr6:30152844-30152845(-) m6A 3'UTR//exon       24284625
chr6:30152874-30152875(-) m6A 3'UTR//exon       24284625
chr6:30153136-30153137(-) m6A 3'UTR//exon       24284625//24981863//27773535
chr6:30153188-30153189(-) m6A 3'UTR//exon       24981863
chr6:30153192-30153193(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535
chr6:30153252-30153253(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535
chr6:30153291-30153292(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535
chr6:30153302-30153303(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535
chr6:30153419-30153420(-) m6A 3'UTR//exon       24284625//24209618//27773535//22575960
chr6:30153543-30153544(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:30153592-30153593(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:30153658-30153659(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:30153675-30153676(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:30153745-30153746(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:30153920-30153921(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:30153941-30153942(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:30153998-30153999(-) m1A CDS//exon       26863196//26863410
chr6:30154121-30154122(-) m1A CDS//exon       26863196//26863410
chr6:30154280-30154281(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:30154319-30154320(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:30154929-30154930(-) m6A intron       27773535
chr6:30154953-30154954(-) m6A intron       27773535
chr6:30154960-30154961(-) m6A intron       27773535
chr6:30155024-30155025(-) m6A intron       27773535
chr6:30156946-30156947(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr6:30156960-30156961(-) m6A CDS//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr6:30157231-30157232(-) m6A CDS//exon       24284625//24209618//27773535//22575960
chr6:30157251-30157252(-) m6A CDS//exon       24284625
chr6:30157279-30157280(-) m6A CDS//exon       24284625
chr6:30157792-30157793(-) m6A CDS//exon       27371828//27773536
chr6:30157801-30157802(-) m6A CDS//exon       27371828//27773536
chr6:30157810-30157811(-) m6A CDS//exon       27371828//27773536
chr6:30157926-30157927(-) m6A exon//intron       27371828//27773536
chr6:30164334-30164335(-) m6A CDS       24284625//24209618//27773535//27371828//27773536
chr6:30164433-30164434(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chr6:30164445-30164446(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chr6:30164509-30164510(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chr6:30166257-30166258(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chr6:30166263-30166264(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chr6:30166287-30166288(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22575960
chr6:30166629-30166630(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:30166650-30166651(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:30166689-30166690(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//27371828//27773536//22575960//22608085
chr6:30166806-30166807(-) m6A CDS//intron       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085
chr6:30166891-30166892(-) m6A 5'UTR//intron       24284625//24209618//24981863//27773535//27371828//22608085
chr6:30166901-30166902(-) m6A 5'UTR//intron       24284625//24209618//24981863//27773535//27371828//22608085
chr6:30166923-30166924(-) m1A 5'UTR//intron       26863196
chr6:30172447-30172448(-) m6A 5'UTR//exon//intron       24284625//24209618//27773535
chr6:30172493-30172494(-) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535
chr6:30181084-30181085(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27773535
chr6:30181141-30181142(-) m6A 5'UTR//exon       24284625//24209618//25456834//24981863//27773535
chr6:30181148-30181149(-) m6A 5'UTR       24284625//25456834//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate TRIM26
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: TRIM26

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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