Basic Information:

  VIRBase ID:  

VHID00506458

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          ZFP36:  NM_003407     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	ZFP36
miRBase Accession/Entrez ID	MIMAT0001581	7538
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	G0S24//GOS24//NUP475//RNF162A//TIS11//TTP//zfp-36

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	ZFP36	chr19:39897641-39897642(+) m6A CDS//intron       24981863 chr19:39897729-39897730(+) m6A CDS//intron       24981863 chr19:39898093-39898094(+) m6A CDS//intron       25456834//24981863 chr19:39898100-39898101(+) m6A CDS//intron       25456834//24981863 chr19:39898115-39898116(+) m6A CDS//intron       25456834 chr19:39898433-39898434(+) m6A 3'UTR//CDS       25456834 chr19:39898465-39898466(+) m6A 3'UTR//CDS       24284625 chr19:39898673-39898674(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942 chr19:39898688-39898689(+) m6A 3'UTR//CDS       24284625//24209618//25456834//24981863//26404942 chr19:39898792-39898793(+) m6A 3'UTR//CDS       24284625//25456834//24981863//26404942 chr19:39898869-39898870(+) m6A CDS       24284625//24209618//25456834//24981863//26404942 chr19:39898943-39898944(+) m6A CDS       24284625//24209618//25456834//24981863 chr19:39899028-39899029(+) m6A CDS       24284625//25456834//24981863 chr19:39899088-39899089(+) m6A CDS       24284625//25456834//24981863 chr19:39899168-39899169(+) m6A CDS       24284625//24981863 chr19:39899413-39899414(+) m6A 3'UTR       25456834//24981863//26404942 chr19:39899430-39899431(+) m6A 3'UTR       25456834//24981863//26404942 chr19:39899439-39899440(+) m6A 3'UTR       25456834//24981863//26404942 chr19:39899703-39899704(+) m6A 3'UTR       27773535 chr19:39899735-39899736(+) m6A 3'UTR       27773535 chr19:39899804-39899805(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	ZFP36	Exosome Blood     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: ZFP36

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.