Detail Information

Basic Information:


  VIRBase ID:  

VHID00506381

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           VCP:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p VCP
miRBase
Accession/Entrez ID		 MIMAT0001581 7415
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - CDC48//FTDALS6//p97//TERA

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR VCP
chr9:35058515(-) A-I      intronic
chr9:35066380(-) A-I      intronic
chr9:35066350(-) A-I      intronic
chr9:35066165(-) A-I      intronic
chr9:35064453(-) A-I      intronic
chr9:35065113(-) A-I      intronic
chr9:35066015(-) A-I      intronic
chr9:35058516(-) A-I      intronic
chr9:35066348(-) A-I      intronic
chr9:35064509(-) A-I      intronic
chr9:35066040(-) A-I      intronic
chr9:35066036(-) A-I      intronic
chr9:35066076(-) A-I      intronic
chr9:35066183(-) A-I      intronic
chr9:35066184(-) A-I      intronic
chr9:35066210(-) A-I      intronic
chr9:35066499(-) A-I      intronic
chr9:35066503(-) A-I      intronic
chr9:35065138(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase VCP
chr9:35056078-35056079(-) m6A 3'UTR       27773535
chr9:35056149-35056150(-) m6A 3'UTR       24284625//27773535
chr9:35056255-35056256(-) m6A 3'UTR       24284625//24981863//26404942//27773535//22575960//22608085
chr9:35056373-35056374(-) m6A 3'UTR       24284625//24981863//27773535//22575960//22608085
chr9:35056518-35056519(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr9:35056583-35056584(-) m6A 3'UTR       24284625//24981863//27773535
chr9:35056609-35056610(-) m6A 3'UTR       24284625//24981863//27773535
chr9:35056631-35056632(-) m6A 3'UTR       24284625//27773535
chr9:35056805-35056806(-) m6A 3'UTR       26404942//27773535//22575960
chr9:35056822-35056823(-) m6A 3'UTR       27773535//22575960
chr9:35056937-35056938(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr9:35056966-35056967(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr9:35056992-35056993(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr9:35057033-35057034(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr9:35057074-35057075(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr9:35057138-35057139(-) m6A CDS//exon       24284625//24209618//24981863//26404942//27773535//22575960
chr9:35057204-35057205(-) m6A CDS//exon       24209618//26404942//27773535//22575960
chr9:35057406-35057407(-) m6A CDS//exon       27773535//22575960
chr9:35057605-35057606(-) m6A exon//intron       24981863//27773535
chr9:35057613-35057614(-) m6A exon//intron       24981863//27773535
chr9:35057819-35057820(-) m6A exon//intron       24981863//26404942
chr9:35059077-35059078(-) m6A CDS//exon       24981863//26404942//22575960
chr9:35059208-35059209(-) m6A CDS//exon       26404942//22575960
chr9:35059842-35059843(-) m6A exon//intron       22575960
chr9:35060846-35060847(-) m6A CDS//exon       26404942//27773535
chr9:35060880-35060881(-) m6A CDS//exon       26404942//27773535
chr9:35061042-35061043(-) m6A CDS//exon       26404942//27773535//22575960
chr9:35061064-35061065(-) m6A CDS//exon       26404942//22575960
chr9:35061163-35061164(-) m6A CDS//exon       26404942
chr9:35061576-35061577(-) m6A CDS//exon       26404942
chr9:35061583-35061584(-) m6A CDS//exon       26404942
chr9:35061607-35061608(-) m6A CDS//exon       26404942
chr9:35062033-35062034(-) m6A CDS//exon       24981863//26404942
chr9:35062134-35062135(-) m6A CDS//exon       24981863//26404942//22575960
chr9:35062151-35062152(-) m6A exon//intron       24981863//26404942//22575960
chr9:35063031-35063032(-) m6A CDS//exon       26404942
chr9:35063040-35063041(-) m6A CDS//exon       26404942
chr9:35063050-35063051(-) m6A CDS//exon       26404942
chr9:35064183-35064184(-) m6A CDS//exon       26404942
chr9:35064195-35064196(-) m6A CDS//exon       26404942//22575960
chr9:35065287-35065288(-) m6A CDS//exon       26404942
chr9:35068272-35068273(-) m6A 5'UTR//CDS//exon       26404942

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate VCP
Chromatin K562 cells     -
Cytosol K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: VCP

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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