Detail Information

Basic Information:


  VIRBase ID:  

VHID00506329

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           UBP1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p UBP1
miRBase
Accession/Entrez ID		 MIMAT0001581 7342
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - LBP-1a//LBP-1B//LBP1A//LBP1B

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR UBP1
chr3:33462105(-) A-I      intronic
chr3:33468552(-) A-I      intronic
chr3:33468562(-) A-I      intronic
chr3:33468724(-) A-I      intronic
chr3:33469454(-) A-I      intronic
chr3:33475069(-) A-I      intronic
chr3:33462119(-) A-I      intronic
chr3:33469458(-) A-I      intronic
chr3:33473633(-) A-I      intronic
chr3:33470843(-) A-I      intronic
chr3:33462135(-) A-I      intronic
chr3:33462154(-) A-I      intronic
chr3:33462158(-) A-I      intronic
chr3:33462861(-) A-I      intronic
chr3:33462113(-) A-I      intronic
chr3:33460304(-) A-I      intronic
chr3:33461926(-) A-I      intronic
chr3:33461885(-) A-I      intronic
chr3:33461875(-) A-I      intronic
chr3:33462897(-) A-I      intronic
chr3:33463034(-) A-I      intronic
chr3:33463373(-) A-I      intronic
chr3:33470870(-) A-I      intronic
chr3:33463379(-) A-I      intronic
chr3:33470982(-) A-I      intronic
chr3:33473599(-) A-I      intronic
chr3:33473678(-) A-I      intronic
chr3:33473784(-) A-I      intronic
chr3:33474658(-) A-I      intronic
chr3:33474713(-) A-I      intronic
chr3:33474731(-) A-I      intronic
chr3:33460289(-) A-I      intronic
chr3:33460227(-) A-I      intronic
chr3:33474732(-) A-I      intronic
chr3:33474746(-) A-I      intronic
chr3:33471038(-) A-I      intronic
chr3:33473734(-) A-I      intronic
chr3:33477081(-) A-I      intronic
chr3:33477003(-) A-I      intronic
chr3:33464643(-) A-I      intronic
chr3:33476405(-) A-I      intronic
chr3:33476354(-) A-I      intronic
chr3:33476276(-) A-I      intronic
chr3:33476255(-) A-I      intronic
chr3:33476246(-) A-I      intronic
chr3:33475123(-) A-I      intronic
chr3:33475093(-) A-I      intronic
chr3:33469508(-) A-I      intronic
chr3:33475082(-) A-I      intronic
chr3:33470957(-) A-I      intronic
chr3:33473603(-) A-I      intronic
chr3:33473625(-) A-I      intronic
chr3:33464647(-) A-I      intronic
chr3:33464648(-) A-I      intronic
chr3:33464656(-) A-I      intronic
chr3:33464795(-) A-I      intronic
chr3:33464711(-) A-I      intronic
chr3:33477069(-) A-I      intronic
chr3:33477124(-) A-I      intronic
chr3:33474717(-) A-I      intronic
chr3:33475896(-) A-I      intronic
chr3:33469530(-) A-I      intronic
chr3:33476963(-) A-I      intronic
chr3:33475112(-) A-I      intronic
chr3:33468494(-) A-I      intronic
chr3:33464135(-) A-I      intronic
chr3:33464700(-) A-I      intronic
chr3:33474747(-) A-I      intronic
chr3:33468650(-) A-I      intronic
chr3:33461856(-) A-I      intronic
chr3:33472986(-) A-I      intronic
chr3:33473120(-) A-I      intronic
chr3:33473707(-) A-I      intronic
chr3:33461894(-) A-I      intronic
chr3:33468651(-) A-I      intronic
chr3:33464782(-) A-I      intronic
chr3:33463323(-) A-I      intronic
chr3:33473740(-) A-I      intronic
chr3:33477013(-) A-I      intronic
chr3:33473691(-) A-I      intronic
chr3:33475416(-) A-I      intronic
chr3:33459933(-) A-I      intronic
chr3:33471094(-) A-I      intronic
chr3:33464122(-) A-I      intronic
chr3:33471093(-) A-I      intronic
chr3:33475954(-) A-I      intronic
chr3:33469562(-) A-I      intronic
chr3:33464173(-) A-I      intronic
chr3:33472985(-) A-I      intronic
chr3:33476275(-) A-I      intronic
chr3:33475902(-) A-I      intronic
chr3:33476383(-) A-I      intronic
chr3:33462929(-) A-I      intronic
chr3:33464171(-) A-I      intronic
chr3:33460871(-) A-I      intronic
chr3:33469449(-) A-I      intronic
chr3:33476953(-) A-I      intronic
chr3:33469439(-) A-I      intronic
chr3:33474620(-) A-I      intronic
chr3:33463436(-) A-I      intronic
chr3:33460299(-) A-I      intronic
chr3:33469517(-) A-I      intronic
chr3:33473156(-) A-I      intronic
chr3:33472995(-) A-I      intronic
chr3:33474691(-) A-I      intronic
chr3:33473704(-) A-I      intronic
chr3:33473602(-) A-I      intronic
chr3:33466293(-) A-I      intronic
chr3:33473185(-) A-I      intronic
chr3:33461929(-) A-I      intronic
chr3:33475957(-) A-I      intronic
chr3:33461890(-) A-I      intronic
chr3:33460251(-) A-I      intronic
chr3:33469587(-) A-I      intronic
chr3:33468597(-) A-I      intronic
chr3:33477009(-) A-I      intronic
chr3:33463453(-) A-I      intronic
chr3:33474965(-) A-I      intronic
chr3:33463370(-) A-I      intronic
chr3:33477095(-) A-I      intronic
chr3:33469598(-) A-I      intronic
chr3:33464705(-) A-I      intronic
chr3:33473062(-) A-I      intronic
chr3:33463284(-) A-I      intronic
chr3:33473668(-) A-I      intronic
chr3:33461878(-) A-I      intronic
chr3:33470959(-) A-I      intronic
chr3:33471080(-) A-I      intronic
chr3:33464714(-) A-I      intronic
chr3:33469425(-) A-I      intronic
chr3:33460736(-) A-I      intronic
chr3:33475997(-) A-I      intronic
chr3:33474625(-) A-I      intronic
chr3:33476443(-) A-I      intronic
chr3:33473056(-) A-I      intronic
chr3:33464601(-) A-I      intronic
chr3:33470903(-) A-I      intronic
chr3:33476051(-) A-I      intronic
chr3:33460134(-) A-I      intronic
chr3:33470967(-) A-I      intronic
chr3:33473218(-) A-I      intronic
chr3:33475928(-) A-I      intronic
chr3:33463493(-) A-I      intronic
chr3:33468565(-) A-I      intronic
chr3:33475101(-) A-I      intronic
chr3:33462980(-) A-I      intronic
chr3:33474982(-) A-I      intronic
chr3:33473106(-) A-I      intronic
chr3:33460188(-) A-I      intronic
chr3:33475345(-) A-I      intronic
chr3:33463454(-) A-I      intronic
chr3:33473699(-) A-I      intronic
chr3:33470954(-) A-I      intronic
chr3:33463521(-) A-I      intronic
chr3:33469511(-) A-I      intronic
chr3:33463420(-) A-I      intronic
chr3:33476343(-) A-I      intronic
chr3:33472973(-) A-I      intronic
chr3:33471022(-) A-I      intronic
chr3:33473113(-) A-I      intronic
chr3:33475941(-) A-I      intronic
chr3:33473043(-) A-I      intronic
chr3:33466321(-) A-I      intronic
chr3:33459930(-) A-I      intronic
chr3:33475410(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED UBP1
chr3:33477095(-) A-I intron -    21960545
chr3:33459930(-) A-G intron -    22484847
chr3:33459933(-) A-G intron -    22484847
chr3:33460134(-) A-G intron -    22484847
chr3:33460188(-) A-G intron -    22484847
chr3:33460229(-) A-G intron -    22484847
chr3:33460251(-) A-G intron -    22484847
chr3:33460299(-) A-G intron -    22484847
chr3:33461037(-) A-G intron -    22484847
chr3:33461081(-) A-G intron -    22484847
chr3:33462098(-) T-C intron -    22484847
chr3:33463420(-) A-G intron -    22484847
chr3:33463454(-) A-G intron -    22484847
chr3:33463521(-) A-G intron -    22484847
chr3:33464117(-) A-G intron -    22484847
chr3:33464122(-) A-G intron -    22484847
chr3:33464542(-) A-C intron -    22484847
chr3:33464700(-) A-G intron -    22484847
chr3:33464705(-) A-G intron -    22484847
chr3:33464711(-) A-G intron -    22484847
chr3:33464714(-) A-G intron -    22484847
chr3:33464781(-) A-G intron -    22484847
chr3:33464782(-) A-G intron -    22484847
chr3:33468494(-) A-G intron -    22484847
chr3:33468658(-) A-G intron -    22484847
chr3:33469587(-) A-G intron -    22484847
chr3:33470903(-) A-G intron -    22484847
chr3:33470906(-) A-G intron -    22484847
chr3:33470959(-) A-G intron -    22484847
chr3:33470960(-) A-G intron -    22484847
chr3:33470967(-) A-G intron -    22484847
chr3:33471022(-) A-G intron -    22484847
chr3:33471080(-) A-G intron -    22484847
chr3:33473056(-) A-G intron -    22484847
chr3:33473106(-) A-G intron -    22484847
chr3:33473110(-) A-G intron -    22484847
chr3:33473113(-) A-G intron -    22484847
chr3:33473120(-) A-G intron -    22484847
chr3:33473156(-) A-G intron -    22484847
chr3:33473185(-) A-G intron -    22484847
chr3:33473186(-) A-G intron -    22484847
chr3:33473235(-) C-T intron -    22484847
chr3:33473691(-) A-G intron -    22484847
chr3:33473704(-) A-G intron -    22484847
chr3:33474691(-) A-G intron -    22484847
chr3:33474717(-) A-G intron -    22484847
chr3:33474721(-) A-G intron -    22484847
chr3:33474747(-) A-G intron -    22484847
chr3:33475101(-) A-G intron -    22484847
chr3:33475410(-) A-G intron -    22484847
chr3:33475416(-) A-G intron -    22484847
chr3:33475927(-) A-G intron -    22484847
chr3:33475941(-) A-G intron -    22484847
chr3:33476382(-) A-G intron -    22484847
chr3:33476443(-) A-G intron -    22484847
chr3:33477009(-) A-G intron -    22484847
chr3:33477044(-) A-G intron -    22484847
chr3:33477069(-) A-G intron -    22484847
chr3:33477095(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase UBP1
chr3:33430563-33430564(-) m6A 3'UTR//exon       27773535
chr3:33430648-33430649(-) m6A 3'UTR//exon       27773535
chr3:33430726-33430727(-) m6A 3'UTR//exon       27773535
chr3:33430794-33430795(-) m6A 3'UTR//exon       27773535
chr3:33430815-33430816(-) m6A 3'UTR//exon       27773535
chr3:33430838-33430839(-) m6A 3'UTR//exon       27773535
chr3:33430923-33430924(-) m6A 3'UTR//exon       27773535
chr3:33430946-33430947(-) m6A 3'UTR//exon       24284625//26404942//27773535
chr3:33431034-33431035(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr3:33431108-33431109(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//22608085
chr3:33431146-33431147(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27773535//22608085
chr3:33431205-33431206(-) m6A 3'UTR//exon       24284625//24209618//24981863//28052920//27773535//22608085
chr3:33431389-33431390(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr3:33431420-33431421(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr3:33431471-33431472(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr3:33431703-33431704(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//27371828//22608085
chr3:33431761-33431762(-) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//27371828//22608085
chr3:33431804-33431805(-) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22608085
chr3:33431809-33431810(-) m6A 3'UTR//exon       24284625//24981863//26404942//27773535//22608085
chr3:33432886-33432887(-) m6A exon//intron       27773535
chr3:33432965-33432966(-) m6A exon//intron       27773535
chr3:33433491-33433492(-) m6A exon//intron       27773535
chr3:33433612-33433613(-) m6A exon//intron       27773535
chr3:33433670-33433671(-) m6A exon//intron       27773535
chr3:33441699-33441700(-) m6A CDS//exon       27773535
chr3:33441721-33441722(-) m6A CDS//exon       24284625//27773535
chr3:33441743-33441744(-) m6A CDS//exon       24284625//27773535
chr3:33442464-33442465(-) m6A CDS//exon       24284625//27773535
chr3:33444295-33444296(-) m6A CDS//exon       24284625//24981863//27773535
chr3:33450212-33450213(-) m6A CDS//exon//intron       24284625//24981863//27773535//27371828
chr3:33450225-33450226(-) m6A CDS//exon//intron       24981863//27773535//27371828
chr3:33450253-33450254(-) m6A CDS//exon//intron       24981863//27773535//27371828
chr3:33450783-33450784(-) m6A CDS//exon       24981863
chr3:33450810-33450811(-) m6A 5'UTR//CDS//exon       24981863
chr3:33450817-33450818(-) m6A 5'UTR//CDS//exon       24981863
chr3:33450824-33450825(-) m6A 5'UTR//CDS//exon       24981863
chr3:33457528-33457529(-) m6A exon//intron       24981863
chr3:33481881-33481882(-) m6A 5'UTR//intron       25456834//24981863//27773536
chr3:33482008-33482009(-) m6A 5'UTR//intron       25456834

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate UBP1
Chromatin K562 cells     -
Cytosol HCC cell line (HepG2)|K562 cells     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)|K562 cells     -
Membrane HCC cell line (HepG2)     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: UBP1

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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