Detail Information

Basic Information:


  VIRBase ID:  

VHID00506324

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           UBE2N:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p UBE2N
miRBase
Accession/Entrez ID		 MIMAT0001581 7334
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - HEL-S-71//UBC13//UBC13//UbcH-ben//UbcH13//UBCHBEN

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR UBE2N
chr12:93803823(-) A-I      NonSyn:Asn->Asp
chr12:93803815(-) A-I      Syn:Stp->Stp
chr12:93803816(-) A-I      Syn:Stp->Stp
chr12:93829005(-) A-I      intronic
chr12:93833160(-) A-I      intronic
chr12:93828990(-) A-I      intronic
chr12:93803799(-) A-I      3'UTR
chr12:93827992(-) A-I      intronic
chr12:93803788(-) A-I      3'UTR
chr12:93803808(-) A-I      3'UTR
chr12:93803770(-) A-I      3'UTR
chr12:93803798(-) A-I      3'UTR
chr12:93824760(-) A-I      intronic
chr12:93821922(-) A-I      intronic
chr12:93833110(-) A-I      intronic
chr12:93821859(-) A-I      intronic
chr12:93812040(-) A-I      intronic
chr12:93812017(-) A-I      intronic
chr12:93810616(-) A-I      intronic
chr12:93805741(-) A-I      intronic
chr12:93805723(-) A-I      intronic
chr12:93805719(-) A-I      intronic
chr12:93805638(-) A-I      intronic
chr12:93833208(-) A-I      intronic
chr12:93829954(-) A-I      intronic
chr12:93805637(-) A-I      intronic
chr12:93805598(-) A-I      intronic
chr12:93831508(-) A-I      intronic
chr12:93831502(-) A-I      intronic
chr12:93830043(-) A-I      intronic
chr12:93831501(-) A-I      intronic
chr12:93831483(-) A-I      intronic
chr12:93831482(-) A-I      intronic
chr12:93831453(-) A-I      intronic
chr12:93831338(-) A-I      intronic
chr12:93831316(-) A-I      intronic
chr12:93830828(-) A-I      intronic
chr12:93830099(-) A-I      intronic
chr12:93831561(-) A-I      intronic
chr12:93829665(-) A-I      intronic
chr12:93829662(-) A-I      intronic
chr12:93829640(-) A-I      intronic
chr12:93829363(-) A-I      intronic
chr12:93829210(-) A-I      intronic
chr12:93829186(-) A-I      intronic
chr12:93829166(-) A-I      intronic
chr12:93829127(-) A-I      intronic
chr12:93829119(-) A-I      intronic
chr12:93805607(-) A-I      intronic
chr12:93829066(-) A-I      intronic
chr12:93827896(-) A-I      intronic
chr12:93825922(-) A-I      intronic
chr12:93825859(-) A-I      intronic
chr12:93825851(-) A-I      intronic
chr12:93825842(-) A-I      intronic
chr12:93825836(-) A-I      intronic
chr12:93825805(-) A-I      intronic
chr12:93829019(-) A-I      intronic
chr12:93825775(-) A-I      intronic
chr12:93828992(-) A-I      intronic
chr12:93828809(-) A-I      intronic
chr12:93828789(-) A-I      intronic
chr12:93825767(-) A-I      intronic
chr12:93833060(-) A-I      intronic
chr12:93833097(-) A-I      intronic
chr12:93825753(-) A-I      intronic
chr12:93824881(-) A-I      intronic
chr12:93824854(-) A-I      intronic
chr12:93824846(-) A-I      intronic
chr12:93824840(-) A-I      intronic
chr12:93824798(-) A-I      intronic
chr12:93824761(-) A-I      intronic
chr12:93830516(-) A-I      intronic
chr12:93805545(-) A-I      intronic
chr12:93831410(-) A-I      intronic
chr12:93805747(-) A-I      intronic
chr12:93815142(-) A-I      intronic
chr12:93805740(-) A-I      intronic
chr12:93833240(-) A-I      intronic
chr12:93830014(-) A-I      intronic
chr12:93831448(-) A-I      intronic
chr12:93805671(-) A-I      intronic
chr12:93830795(-) A-I      intronic
chr12:93812083(-) A-I      intronic
chr12:93829342(-) A-I      intronic
chr12:93807721(-) A-I      intronic
chr12:93830821(-) A-I      intronic
chr12:93830468(-) A-I      intronic
chr12:93815050(-) A-I      intronic
chr12:93829004(-) A-I      intronic
chr12:93805634(-) A-I      intronic
chr12:93831457(-) A-I      intronic
chr12:93805558(-) A-I      intronic
chr12:93810369(-) A-I      intronic
chr12:93830873(-) A-I      intronic
chr12:93810368(-) A-I      intronic
chr12:93830997(-) A-I      intronic
chr12:93824708(-) A-I      intronic
chr12:93805572(-) A-I      intronic
chr12:93823044(-) A-I      intronic
chr12:93831390(-) A-I      intronic
chr12:93813012(-) A-I      intronic
chr12:93812077(-) A-I      intronic
chr12:93830036(-) A-I      intronic
chr12:93830008(-) A-I      intronic
chr12:93812023(-) A-I      intronic
chr12:93820969(-) A-I      intronic
chr12:93813018(-) A-I      intronic
chr12:93805630(-) A-I      intronic
chr12:93813004(-) A-I      intronic
chr12:93811965(-) A-I      intronic
chr12:93821909(-) A-I      intronic
chr12:93812039(-) A-I      intronic
chr12:93821919(-) A-I      intronic
chr12:93820763(-) A-I      intronic
chr12:93826820(-) A-I      intronic
chr12:93826982(-) A-I      intronic
chr12:93831489(-) A-I      intronic
chr12:93830024(-) A-I      intronic
chr12:93828840(-) A-I      intronic
chr12:93833124(-) A-I      intronic
chr12:93815212(-) A-I      intronic
chr12:93810584(-) A-I      intronic
chr12:93810603(-) A-I      intronic
chr12:93811967(-) A-I      intronic
chr12:93826847(-) A-I      intronic
chr12:93825921(-) A-I      intronic
chr12:93829966(-) A-I      intronic
chr12:93833143(-) A-I      intronic
chr12:93831356(-) A-I      intronic
chr12:93829970(-) A-I      intronic
chr12:93811795(-) A-I      intronic
chr12:93830464(-) A-I      intronic
chr12:93824964(-) A-I      intronic
chr12:93815110(-) A-I      intronic
chr12:93830518(-) A-I      intronic
chr12:93827985(-) A-I      intronic
chr12:93833028(-) A-I      intronic
chr12:93828801(-) A-I      intronic
chr12:93830079(-) A-I      intronic
chr12:93830510(-) A-I      intronic
chr12:93821862(-) A-I      intronic
chr12:93833130(-) A-I      intronic
chr12:93821863(-) A-I      intronic
chr12:93821855(-) A-I      intronic
chr12:93830152(-) A-I      intronic
chr12:93831328(-) A-I      intronic
chr12:93831355(-) A-I      intronic
chr12:93827826(-) A-I      intronic
chr12:93825973(-) A-I      intronic
chr12:93821865(-) A-I      intronic
chr12:93830078(-) A-I      intronic
chr12:93805541(-) A-I      intronic
chr12:93826817(-) A-I      intronic
chr12:93830022(-) A-I      intronic
chr12:93831407(-) A-I      intronic
chr12:93810449(-) A-I      intronic
chr12:93830153(-) A-I      intronic
chr12:93830548(-) A-I      intronic
chr12:93830040(-) A-I      intronic
chr12:93830437(-) A-I      intronic
chr12:93810446(-) A-I      intronic
chr12:93821938(-) A-I      intronic
chr12:93810447(-) A-I      intronic
chr12:93821806(-) A-I      intronic
chr12:93812045(-) A-I      intronic
chr12:93830772(-) A-I      intronic
chr12:93821910(-) A-I      intronic
chr12:93805503(-) A-I      intronic
chr12:93821759(-) A-I      intronic
chr12:93828779(-) A-I      intronic
chr12:93813054(-) A-I      intronic
chr12:93815074(-) A-I      intronic
chr12:93831322(-) A-I      intronic
chr12:93828832(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED UBE2N
chr12:93830079(-) A-I intron -    21960545
chr12:93810449(-) A-G intron -    22484847
chr12:93830079(-) A-G intron -    22484847
chr12:93830510(-) A-G intron -    22484847
chr12:93830516(-) A-G intron -    22484847
chr12:93805630(-) A-G intron -    22484847
chr12:93805747(-) A-G intron -    22484847
chr12:93805758(-) T-C intron -    22484847
chr12:93810446(-) A-G intron -    22484847
chr12:93810447(-) A-G intron -    22484847
chr12:93810603(-) A-G intron -    22484847
chr12:93812039(-) A-G intron -    22484847
chr12:93812045(-) A-G intron -    22484847
chr12:93813012(-) A-G intron -    22484847
chr12:93821919(-) A-G intron -    22484847
chr12:93821938(-) A-G intron -    22484847
chr12:93826847(-) A-G intron -    22484847
chr12:93826982(-) A-G intron -    22484847
chr12:93827985(-) A-G intron -    22484847
chr12:93828801(-) A-G intron -    22484847
chr12:93829342(-) A-G intron -    22484847
chr12:93829966(-) A-G intron -    22484847
chr12:93829970(-) A-G intron -    22484847
chr12:93830013(-) G-A intron -    22484847
chr12:93830014(-) A-G intron -    22484847
chr12:93830024(-) A-G intron -    22484847
chr12:93830036(-) A-G intron -    22484847
chr12:93830078(-) A-G intron -    22484847
chr12:93830149(-) T-C intron -    22484847
chr12:93830152(-) A-G intron -    22484847
chr12:93830153(-) A-G intron -    22484847
chr12:93830437(-) A-G intron -    22484847
chr12:93830464(-) A-G intron -    22484847
chr12:93830518(-) A-G intron -    22484847
chr12:93830821(-) A-G intron -    22484847
chr12:93831322(-) A-G intron -    22484847
chr12:93831328(-) A-G intron -    22484847
chr12:93831355(-) A-G intron -    22484847
chr12:93831356(-) A-G intron -    22484847
chr12:93831390(-) A-G intron -    22484847
chr12:93831407(-) A-G intron -    22484847
chr12:93831410(-) A-G intron -    22484847
chr12:93831448(-) A-G intron -    22484847
chr12:93831457(-) A-G intron -    22484847
chr12:93831489(-) A-G intron -    22484847
chr12:93833130(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase UBE2N
chr12:93799459-93799460(-) m6A exon       27773535
chr12:93799522-93799523(-) m6A 3'UTR//exon       27773535
chr12:93800955-93800956(-) m6A 3'UTR//exon       27773535
chr12:93800999-93801000(-) m6A 3'UTR//exon       25456834//27773535//22608085
chr12:93801018-93801019(-) m6A 3'UTR//exon       25456834//27773535//22608085
chr12:93801045-93801046(-) m6A 3'UTR//exon       25456834//27773535//22608085
chr12:93801092-93801093(-) m6A 3'UTR//exon       27773535//22608085
chr12:93803700-93803701(-) m6A 3'UTR       24284625
chr12:93803724-93803725(-) m6A 3'UTR       24284625//24981863
chr12:93803738-93803739(-) m6A 3'UTR       24284625//24981863
chr12:93803767-93803768(-) m6A 3'UTR       24284625//24981863
chr12:93803843-93803844(-) m6A 3'UTR//CDS       24284625//24981863
chr12:93803895-93803896(-) m6A 3'UTR//intron       24284625//24981863
chr12:93804446-93804447(-) m6A 3'UTR//intron       24981863
chr12:93804512-93804513(-) m6A 3'UTR//CDS//intron       24981863
chr12:93804863-93804864(-) m6A CDS//intron       24284625//27773535
chr12:93804940-93804941(-) m6A 5'UTR//CDS       24284625//27773535//27371828
chr12:93804946-93804947(-) m6A 5'UTR//CDS       24284625//27773535//27371828
chr12:93804954-93804955(-) m6A 5'UTR//CDS       24284625//27773535//27371828
chr12:93805027-93805028(-) m6A 5'UTR//CDS       24284625//25456834//27773535//27371828//27773536//22608085
chr12:93805051-93805052(-) m6A 5'UTR//CDS       24284625//25456834//27773535//27371828//27773536//22608085
chr12:93805071-93805072(-) m6A 5'UTR//CDS       24284625//25456834//24981863//27371828//27773536//22608085
chr12:93818074-93818075(-) m6A 5'UTR//intron       24284625//25456834//24981863//27371828//27773536//22608085
chr12:93835676-93835677(-) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536//22608085
chr12:93835688-93835689(-) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536//22608085
chr12:93835728-93835729(-) m6A 5'UTR       24284625//25456834//24981863//27371828//27773536//22608085
chr12:93835803-93835804(-) m6A 5'UTR       25456834//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate UBE2N
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Ribosome HEK-293 cells     22199352
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: UBE2N

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

Starting a new search, please wait ...