Detail Information

Basic Information:


  VIRBase ID:  

VHID00506269

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           TSPYL1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p TSPYL1
miRBase
Accession/Entrez ID		 MIMAT0001581 7259
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - TSPYL

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR TSPYL1
chr6:116596835(-) A-I      3'UTR
chr6:116596851(-) A-I      3'UTR
chr6:116596880(-) A-I      3'UTR
chr6:116596839(-) A-I      3'UTR
chr6:116596841(-) A-I      3'UTR
chr6:116596863(-) A-I      3'UTR
chr6:116596869(-) A-I      3'UTR
chr6:116596877(-) A-I      3'UTR

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase TSPYL1
chr6:116598420-116598421(-) m6A 3'UTR       24981863//27773535//22608085
chr6:116598536-116598537(-) m6A 3'UTR       24284625//24981863//28052920//27773535//27371828//22608085
chr6:116598585-116598586(-) m6A 3'UTR       24284625//24981863//28052920//27773535//27371828//22608085
chr6:116598590-116598591(-) m6A 3'UTR       24284625//24981863//28052920//27773535//27371828//22608085
chr6:116598630-116598631(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr6:116598793-116598794(-) m6A 3'UTR       27773535
chr6:116598859-116598860(-) m6A 3'UTR       24284625//27773535
chr6:116598945-116598946(-) m6A 3'UTR       24284625//24209618//24981863
chr6:116599236-116599237(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:116599257-116599258(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:116599346-116599347(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:116599372-116599373(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085
chr6:116599626-116599627(-) m6A 3'UTR       24284625//24209618//24981863//27773535//22575960//22608085
chr6:116599845-116599846(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr6:116599878-116599879(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr6:116599884-116599885(-) m6A CDS       24284625//24209618//24981863//27773535//22608085
chr6:116599907-116599908(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22608085
chr6:116599995-116599996(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr6:116600010-116600011(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22608085
chr6:116600044-116600045(-) m6A CDS       24284625//24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr6:116600054-116600055(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr6:116600060-116600061(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr6:116600139-116600140(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr6:116600187-116600188(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:116600274-116600275(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:116600279-116600280(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:116600304-116600305(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//27773536//22575960//22608085
chr6:116600340-116600341(-) m1A CDS       26863196
chr6:116600524-116600525(-) m6A CDS       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22575960//22608085
chr6:116600827-116600828(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536
chr6:116600950-116600951(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22608085
chr6:116600965-116600966(-) m6A CDS       24284625//24209618//24981863//27773535//27371828//27773536//22608085

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate TSPYL1
Chromatin K562 cells     -
Cytoplasm Nasopharyngeal carcinoma cells     20498841
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Nucleus Nasopharyngeal carcinoma cells     20498841
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: TSPYL1

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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