Basic Information:

  VIRBase ID:  

VHID00506242

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          HSP90B1:  NM_003299     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	HSP90B1
miRBase Accession/Entrez ID	MIMAT0001581	7184
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	ECGP//GP96//GRP94//HEL-S-125m//HEL35//TRA1

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	HSP90B1	chr12:104331716(+) A-I      intronic chr12:104328741(+) A-I      intronic chr12:104330314(+) A-I      intronic chr12:104330165(+) A-I      intronic chr12:104328605(+) A-I      intronic chr12:104338434(+) A-I      intronic chr12:104331735(+) A-I      intronic chr12:104339660(+) A-I      intronic chr12:104328584(+) A-I      intronic chr12:104328579(+) A-I      intronic chr12:104328560(+) A-I      intronic chr12:104328557(+) A-I      intronic chr12:104330304(+) A-I      intronic chr12:104328484(+) A-I      intronic chr12:104330236(+) A-I      intronic chr12:104330345(+) A-I      intronic chr12:104331789(+) A-I      intronic chr12:104331869(+) A-I      intronic chr12:104331898(+) A-I      intronic chr12:104330288(+) A-I      intronic chr12:104330170(+) A-I      intronic chr12:104328641(+) A-I      intronic chr12:104328606(+) A-I      intronic chr12:104331815(+) A-I      intronic chr12:104339008(+) A-I      intronic chr12:104330162(+) A-I      intronic chr12:104331838(+) A-I      intronic chr12:104339680(+) A-I      intronic chr12:104331828(+) A-I      intronic chr12:104330366(+) A-I      intronic chr12:104339653(+) A-I      intronic chr12:104330278(+) A-I      intronic chr12:104332947(+) A-I      intronic chr12:104331890(+) A-I      intronic chr12:104328480(+) A-I      intronic chr12:104339044(+) A-I      intronic chr12:104330142(+) A-I      intronic chr12:104331845(+) A-I      intronic chr12:104331769(+) A-I      intronic chr12:104328753(+) A-I      intronic chr12:104331690(+) A-I      intronic chr12:104338358(+) A-I      intronic chr12:104330270(+) A-I      intronic chr12:104328756(+) A-I      intronic chr12:104339100(+) A-I      intronic chr12:104330210(+) A-I      intronic chr12:104328580(+) A-I      intronic chr12:104338997(+) A-I      intronic chr12:104339607(+) A-I      intronic chr12:104330200(+) A-I      intronic chr12:104330238(+) A-I      intronic chr12:104330830(+) A-I      intronic chr12:104328662(+) A-I      intronic chr12:104339064(+) A-I      intronic chr12:104338438(+) A-I      intronic chr12:104330318(+) A-I      intronic chr12:104331933(+) A-I      intronic chr12:104330187(+) A-I      intronic chr12:104331681(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	HSP90B1	chr12:104330210(+) A-I intron -    22327324 chr12:104330304(+) A-I intron -    22327324 chr12:104330318(+) A-I intron -    22327324 chr12:104330162(+) A-I intron -    21960545 chr12:104330996(+) A-I intron -    21960545 chr12:104330162(+) A-G intron -    22484847 chr12:104330200(+) A-G intron -    22484847 chr12:104330210(+) A-G intron -    22484847 chr12:104330278(+) A-G intron -    22484847 chr12:104330304(+) A-G intron -    22484847 chr12:104338358(+) A-G intron -    22484847 chr12:104339008(+) A-G intron -    22484847 chr12:104339695(+) C-A intron -    22484847 chr12:104339698(+) T-A intron -    22484847 chr12:104328580(+) A-G intron -    22484847 chr12:104328662(+) A-G intron -    22484847 chr12:104331735(+) A-G intron -    22484847 chr12:104332890(+) C-T intron -    22484847 chr12:104338523(+) G-A intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	HSP90B1	chr12:104324196-104324197(+) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr12:104324225-104324226(+) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//26404942//22575960//22608085 chr12:104324268-104324269(+) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:104324275-104324276(+) m6A 5'UTR//exon//intron       24284625//24209618//25456834//24981863//27773535//22575960//22608085 chr12:104325398-104325399(+) Gm 5'UTR//CDS//exon       - chr12:104325417-104325418(+) m6A exon//intron       24209618//24981863//27773535//22575960 chr12:104325444-104325445(+) m6A exon//intron       24284625//24209618//24981863//27773535//22575960 chr12:104326062-104326063(+) m1A 3'UTR//5'UTR//CDS//exon       26863196 chr12:104326105-104326106(+) m6A 3'UTR//5'UTR//CDS//exon       24981863//27773535//22575960 chr12:104326162-104326163(+) m6A 3'UTR//CDS//exon       24981863//27773535//22575960 chr12:104326617-104326618(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535//22575960 chr12:104326701-104326702(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535//22575960 chr12:104327749-104327750(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535//22575960 chr12:104327767-104327768(+) m6A 3'UTR//CDS//exon       24981863//26404942//27773535//22575960 chr12:104327806-104327807(+) m6A CDS//exon       24981863//26404942//27773535 chr12:104327832-104327833(+) m6A CDS//exon       24981863//26404942//27773535 chr12:104327848-104327849(+) m6A CDS//exon       24981863//26404942//27773535 chr12:104327963-104327964(+) m6A CDS//exon       27773535 chr12:104328037-104328038(+) m6A CDS//exon       26404942//27773535 chr12:104331555-104331556(+) m6A CDS//exon       24981863//26404942//27773535 chr12:104332021-104332022(+) m6A exon//intron       24981863//27773535//22608085 chr12:104332061-104332062(+) m6A exon//intron       24981863//27773535//22575960//22608085 chr12:104332080-104332081(+) m6A exon//intron       24981863//27773535//22575960//22608085 chr12:104332117-104332118(+) m6A CDS//exon       24981863//27773535//22575960//22608085 chr12:104332123-104332124(+) m6A CDS//exon       24981863//27773535//22575960//22608085 chr12:104332221-104332222(+) m6A CDS//exon//intron       24981863//27773535//22575960//22608085 chr12:104332228-104332229(+) m6A CDS//exon//intron       24981863//27773535//22575960//22608085 chr12:104333295-104333296(+) m6A CDS//exon//intron       24981863//27773535//22575960//22608085 chr12:104333305-104333306(+) m6A CDS//exon//intron       24981863//27773535//22575960//22608085 chr12:104333312-104333313(+) m6A CDS//exon//intron       24981863//27773535//22575960//22608085 chr12:104333330-104333331(+) m6A CDS//exon//intron       24981863//27773535//22575960//22608085 chr12:104333345-104333346(+) m6A CDS//exon//intron       24981863//27773535//22608085 chr12:104335297-104335298(+) Tm CDS//exon//intron       - chr12:104335613-104335614(+) m6A CDS//exon//intron       27773535 chr12:104335648-104335649(+) m6A CDS//exon//intron       27773535//22575960 chr12:104335665-104335666(+) m6A CDS//exon//intron       27773535//22575960 chr12:104336338-104336339(+) m6A CDS//exon//intron       27773535//22575960 chr12:104336425-104336426(+) m6A CDS//exon//intron       27773535//22575960 chr12:104336439-104336440(+) m6A CDS//exon//intron       27773535//22575960 chr12:104336453-104336454(+) m6A CDS//exon//intron       27773535//22575960 chr12:104336503-104336504(+) m6A CDS//exon//intron       27773535//22575960 chr12:104336531-104336532(+) m6A CDS//exon//intron       27773535 chr12:104336536-104336537(+) m6A CDS//exon//intron       27773535 chr12:104336583-104336584(+) m6A exon//intron       27773535 chr12:104336658-104336659(+) m6A exon//intron       27773535 chr12:104336916-104336917(+) m6A CDS//exon//intron       24981863//27773535//22575960 chr12:104337016-104337017(+) m6A CDS//exon//intron       24981863//27773535//22575960 chr12:104337092-104337093(+) m6A CDS//exon//intron       24981863//27773535//22575960 chr12:104337162-104337163(+) m6A exon//intron       27773535//22575960 chr12:104337639-104337640(+) m6A CDS//exon//intron       24981863//27773535 chr12:104340417-104340418(+) m6A CDS//exon//intron       24981863//27773535 chr12:104340437-104340438(+) m6A CDS//exon//intron       24981863//27773535 chr12:104340454-104340455(+) m6A CDS//exon//intron       24981863//27773535 chr12:104340581-104340582(+) m6A CDS//exon//intron       24981863//27773535 chr12:104340614-104340615(+) m6A CDS//exon//intron       24981863//27773535 chr12:104340648-104340649(+) m6A CDS//exon//intron       24981863//27773535 chr12:104340699-104340700(+) m6A CDS//exon//intron       25456834//24981863//28052920//27773535//27371828//22575960 chr12:104341095-104341096(+) m1A CDS//exon//intron       26863196 chr12:104341107-104341108(+) m1A CDS//exon//intron       26863196 chr12:104341111-104341112(+) m6A CDS//exon//intron       25456834//24981863//28052920//27773535//27371828//22575960 chr12:104341118-104341119(+) Gm CDS//exon//intron       - chr12:104341121-104341122(+) m6A CDS//exon//intron       25456834//24981863//28052920//27773535//27371828//22575960 chr12:104341131-104341132(+) m6A CDS//exon//intron       25456834//24981863//28052920//27773535//27371828//22575960 chr12:104341143-104341144(+) m6A CDS//exon//intron       25456834//24981863//28052920//27773535//27371828//22575960 chr12:104341181-104341182(+) m6A 3'UTR//CDS//exon       25456834//24981863//28052920//27773535//27371828//22575960 chr12:104341191-104341192(+) m1A 3'UTR//CDS//exon       26863196 chr12:104341199-104341200(+) m6A 3'UTR//CDS//exon       25456834//24981863//28052920//27773535//27371828//22575960 chr12:104341511-104341512(+) m6A 3'UTR//exon//intron       24981863//26404942//27773535//22575960 chr12:104347177-104347178(+) m6A 3'UTR       27773535 chr12:104347270-104347271(+) m6A 3'UTR       27773535//27773536 chr12:104347294-104347295(+) m6A 3'UTR       27773535//27773536 chr12:104347321-104347322(+) m6A 3'UTR       27773535//27773536 chr12:104347362-104347363(+) m6A 3'UTR       27773535 chr12:104347370-104347371(+) m6A 3'UTR       27773535 chr12:104347383-104347384(+) m6A 3'UTR       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	HSP90B1	Chromatin K562 cells     - Cytosol K562 cells     - Cytosolic polysome Human T lymphocytes (Jurkat E6-1)     12923260 Endoplasmic reticulum HEK-293T cells     21431749 Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539 ER-bound polysome Human T lymphocytes (Jurkat E6-1)     12923260 Exosome Blood     - Membrane-bound ribosome Cell line (HeLa)     18192611 Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|K562 cells     - Perinuclear Human embryonic kidney cell line (HEK-293)     12923260 Ribosome HEK-293 cells     22199352 Ribosome HeLa cells     25063809

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: HSP90B1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.