Basic Information:

  VIRBase ID:  

VHID00506235

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          TPR:  NM_003292     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	TPR
miRBase Accession/Entrez ID	MIMAT0001581	7175
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	-

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TPR	chr1:186281707-186281708(-) m6A 3'UTR       27773535 chr1:186281713-186281714(-) m6A 3'UTR       27773535 chr1:186281822-186281823(-) Y 3'UTR       26075521 chr1:186283011-186283012(-) m6A 3'UTR       24981863//27773535 chr1:186283027-186283028(-) m6A 3'UTR       24981863//27773535 chr1:186283090-186283091(-) m6A 3'UTR       24981863//28052920//27773535 chr1:186283121-186283122(-) m6A CDS       24981863//28052920//27773535 chr1:186283767-186283768(-) m6A CDS       24981863//26404942//27773535 chr1:186283797-186283798(-) m6A CDS       24981863//27773535 chr1:186283808-186283809(-) m6A CDS       24981863//27773535 chr1:186283815-186283816(-) m6A CDS       24981863//27773535 chr1:186287630-186287631(-) m6A CDS       27773535 chr1:186287694-186287695(-) m6A CDS//exon       27773535 chr1:186292829-186292830(-) m6A CDS       - chr1:186292862-186292863(-) m6A CDS       - chr1:186292919-186292920(-) m6A CDS       - chr1:186292946-186292947(-) m6A CDS       - chr1:186294667-186294668(-) m6A exon//intron       - chr1:186294900-186294901(-) m6A CDS//exon       24981863//28052920//27773535 chr1:186294955-186294956(-) m6A CDS//exon       24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr1:186294973-186294974(-) m6A CDS//exon       24209618//24981863//28052920//26404942//27773535//22575960//22608085 chr1:186295282-186295283(-) m6A CDS//exon       24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr1:186296597-186296598(-) m6A CDS       24209618//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr1:186296625-186296626(-) m1A CDS       26863196 chr1:186296746-186296747(-) m6A CDS       24981863//27773535 chr1:186296757-186296758(-) m6A CDS       24981863//26404942//27773535 chr1:186300670-186300671(-) m6A CDS       26404942//27773535 chr1:186301331-186301332(-) m6A CDS       26404942//27773535 chr1:186302500-186302501(-) m6A CDS       27773535 chr1:186303650-186303651(-) m6A CDS       24981863//27773535 chr1:186304227-186304228(-) m6A CDS       24981863//27773535 chr1:186304243-186304244(-) m6A CDS       24981863//27773535 chr1:186304252-186304253(-) m6A CDS       24981863//27773535 chr1:186304481-186304482(-) m6A CDS       24981863//27773535 chr1:186304511-186304512(-) m6A CDS       24981863//27773535 chr1:186304525-186304526(-) Gm CDS       - chr1:186304532-186304533(-) m6A CDS       24981863//27773535 chr1:186304634-186304635(-) m6A CDS       24981863//27773535//22575960 chr1:186305675-186305676(-) m6A CDS       24981863//27773535 chr1:186305726-186305727(-) m6A CDS       24981863//27773535 chr1:186305760-186305761(-) m6A CDS       24981863//27773535//27371828 chr1:186305784-186305785(-) m6A CDS       24981863//27773535//27371828 chr1:186305807-186305808(-) m6A CDS       24981863//27773535//27371828 chr1:186306188-186306189(-) m6A CDS       24981863//27773535//27371828 chr1:186306216-186306217(-) m6A CDS       24981863//27773535//27371828 chr1:186306256-186306257(-) m6A CDS       24981863//27773535 chr1:186306278-186306279(-) m6A CDS       24981863//27773535 chr1:186307185-186307186(-) m6A CDS       24981863//27773535 chr1:186307199-186307200(-) m6A CDS       24981863//27773535 chr1:186307238-186307239(-) m6A CDS       24981863//27773535 chr1:186307279-186307280(-) m6A CDS       24981863//27773535 chr1:186307292-186307293(-) m6A CDS       24981863//27773535 chr1:186307304-186307305(-) m6A CDS       24981863//27773535//22575960 chr1:186307345-186307346(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186308793-186308794(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186310282-186310283(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960 chr1:186310410-186310411(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960 chr1:186310416-186310417(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960 chr1:186310448-186310449(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960 chr1:186310469-186310470(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960 chr1:186310475-186310476(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960 chr1:186310488-186310489(-) m6A CDS//exon       24981863//28052920//27773535//27371828//22575960 chr1:186310508-186310509(-) m6A CDS//exon       24981863//27773535//27371828//22575960 chr1:186310571-186310572(-) m6A exon//intron       24981863//27773535//27371828 chr1:186310579-186310580(-) m6A exon//intron       24981863//27773535//27371828 chr1:186312496-186312497(-) m6A CDS//exon       24981863 chr1:186312520-186312521(-) m6A CDS//exon       24981863 chr1:186312573-186312574(-) m6A CDS//exon       24981863//22575960 chr1:186313057-186313058(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186313172-186313173(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186313177-186313178(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186313577-186313578(-) m6A CDS       24981863//27773535//22575960 chr1:186314809-186314810(-) m6A CDS       27773535 chr1:186315272-186315273(-) m6A CDS       24981863//27773535 chr1:186315311-186315312(-) m6A CDS       24981863//27773535 chr1:186315317-186315318(-) m6A CDS       24981863//27773535 chr1:186315358-186315359(-) m6A CDS       24981863//27773535//22575960 chr1:186316426-186316427(-) m6A CDS       24981863//27773535//22575960 chr1:186316436-186316437(-) m6A CDS       24981863//27773535//22575960 chr1:186316477-186316478(-) m6A CDS       24981863//28052920//27773535//22575960 chr1:186316497-186316498(-) m6A CDS       24981863//28052920//27773535//22575960 chr1:186316504-186316505(-) m6A CDS       24981863//28052920//27773535//22575960 chr1:186316540-186316541(-) m6A CDS       24981863//28052920//27773535//22575960 chr1:186319363-186319364(-) m6A CDS       24981863//28052920//26404942//27773535//22575960 chr1:186319415-186319416(-) m6A CDS       24981863//26404942//27773535 chr1:186319454-186319455(-) m6A CDS       24981863//26404942//27773535//22575960 chr1:186319480-186319481(-) m6A CDS       24981863//27773535//22575960 chr1:186319496-186319497(-) m6A CDS       24981863//27773535//22575960 chr1:186320491-186320492(-) m6A CDS       24981863//27773535//22575960 chr1:186320536-186320537(-) m6A CDS       24981863//27773535//22575960 chr1:186320542-186320543(-) m6A CDS       24981863//27773535//22575960 chr1:186320569-186320570(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186320574-186320575(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186320580-186320581(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186321115-186321116(-) m6A CDS//exon       27773535 chr1:186321138-186321139(-) m6A CDS//exon       27773535 chr1:186321152-186321153(-) m6A CDS//exon       27773535//27371828 chr1:186322882-186322883(-) m6A CDS//exon       26404942//27773535//27371828//22575960 chr1:186322909-186322910(-) m6A CDS//exon       26404942//27773535//27371828//22575960 chr1:186324606-186324607(-) m6A CDS//exon       24981863 chr1:186324615-186324616(-) m6A CDS//exon       24981863 chr1:186326541-186326542(-) m6A CDS//exon       24981863 chr1:186326548-186326549(-) m6A CDS//exon       24981863 chr1:186326565-186326566(-) m6A CDS//exon       24981863 chr1:186327759-186327760(-) m6A CDS//exon       22575960 chr1:186328942-186328943(-) m6A CDS//exon       24981863//22575960 chr1:186329072-186329073(-) m6A CDS//exon       22575960 chr1:186329080-186329081(-) m6A CDS//exon       22575960 chr1:186329106-186329107(-) m6A CDS//exon       22575960 chr1:186330775-186330776(-) m6A CDS//exon       24981863//27773535 chr1:186330784-186330785(-) m6A CDS//exon       24981863//27773535 chr1:186330805-186330806(-) m6A CDS//exon       24981863//27773535 chr1:186330938-186330939(-) m6A CDS//exon       24981863//26404942//27773535 chr1:186330992-186330993(-) m6A CDS//exon       24981863//26404942//27773535 chr1:186331464-186331465(-) m6A CDS//exon       24981863//27773535 chr1:186331475-186331476(-) m6A CDS//exon       24981863//27773535 chr1:186331494-186331495(-) m6A CDS//exon       24981863//27773535 chr1:186331503-186331504(-) m6A CDS//exon       24981863//27773535 chr1:186332043-186332044(-) m6A CDS//exon       24981863//27773535 chr1:186332051-186332052(-) m6A CDS//exon       24981863//27773535 chr1:186332057-186332058(-) m6A CDS//exon       24981863//27773535 chr1:186332500-186332501(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186332521-186332522(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186332551-186332552(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186337033-186337034(-) m6A CDS//exon       24981863//27773535//22575960 chr1:186337045-186337046(-) m6A CDS//exon       24981863//27773535 chr1:186337056-186337057(-) m6A CDS//exon       24981863//27773535 chr1:186337067-186337068(-) m6A CDS//exon       24981863//27773535 chr1:186337098-186337099(-) m6A CDS//exon       24981863//27773535 chr1:186340137-186340138(-) m6A CDS//exon       24981863//27773535 chr1:186340144-186340145(-) m6A CDS//exon       24981863//27773535 chr1:186342494-186342495(-) m6A CDS//exon       24981863//27773535 chr1:186342532-186342533(-) m6A CDS//exon       24981863//27773535 chr1:186342545-186342546(-) m6A CDS//exon       24981863//27773535 chr1:186344021-186344022(-) Am CDS//exon       - chr1:186344092-186344093(-) m6A CDS//exon       27773535 chr1:186344116-186344117(-) m6A CDS//exon       27773535//27773536 chr1:186344331-186344332(-) m6A 5'UTR//exon//intron       25456834//24981863//27371828//27773536//22608085 chr1:186344763-186344764(-) m6A 5'UTR       25456834//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TPR	Chromatin K562 cells     - Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Exosome Blood     - Insoluble cytoplasm K562 cells     - Membrane K562 cells     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     - Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: TPR

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.