Basic Information:

  VIRBase ID:  

VHID00506186

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          TM7SF2:  NR_102367     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	TM7SF2
miRBase Accession/Entrez ID	MIMAT0001581	7108
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	ANG1//C14SR//DHCR14A//NET47

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	TM7SF2	chr11:64879484-64879485(+) m6A 5'UTR//exon//intron       - chr11:64879560-64879561(+) m6A exon//intron       - chr11:64879602-64879603(+) m6A exon//intron       - chr11:64879661-64879662(+) m6A exon//intron       25456834 chr11:64879795-64879796(+) m6A exon//intron       25456834 chr11:64879820-64879821(+) m6A exon//intron       25456834 chr11:64881041-64881042(+) m6A 3'UTR//CDS//exon//intron       - chr11:64883583-64883584(+) m6A 3'UTR//exon       24981863//27773535//22608085 chr11:64883607-64883608(+) m6A 3'UTR//exon       25456834//24981863//27773535//22608085 chr11:64883644-64883645(+) m6A 3'UTR//exon       25456834//24981863//27773535//22608085 chr11:64883688-64883689(+) m6A 3'UTR//exon       25456834//24981863//27773535//22608085 chr11:64883730-64883731(+) m6A 3'UTR       25456834//24981863//22608085 chr11:64883739-64883740(+) m6A 3'UTR       25456834//24981863//22608085 chr11:64883766-64883767(+) m6A 3'UTR       25456834//24981863//22608085 chr11:64883840-64883841(+) m6A 3'UTR       25456834//24981863//22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	TM7SF2	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleus HCC cell line (HepG2)     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: TM7SF2

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.