Detail Information

Basic Information:


  VIRBase ID:  

VHID00506069

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           ZEB1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p ZEB1
miRBase
Accession/Entrez ID		 MIMAT0001581 6935
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - AREB6//BZP//DELTAEF1//FECD6//NIL2A//PPCD3//TCF8//ZFHEP//ZFHX1A

RNA Editing:


Resource Symbol Editing Position
Lncediting ZEB1
    chr10: 31676192
Resource Symbol Editing Position Change Genetic Region
RADAR ZEB1
chr10:31673005(+) A-I      intronic
chr10:31628501(+) A-I      intronic
chr10:31673088(+) A-I      intronic
chr10:31628541(+) A-I      intronic
chr10:31673085(+) A-I      intronic
chr10:31673050(+) A-I      intronic
chr10:31670846(+) A-I      intronic
chr10:31628552(+) A-I      intronic
chr10:31738888(+) A-I      intronic
chr10:31636330(+) A-I      intronic
chr10:31672928(+) A-I      intronic
chr10:31674657(+) A-I      intronic
chr10:31636419(+) A-I      intronic
chr10:31673071(+) A-I      intronic
chr10:31651736(+) A-I      intronic
chr10:31628631(+) A-I      intronic
chr10:31626793(+) A-I      intronic
chr10:31674556(+) A-I      intronic
chr10:31672972(+) A-I      intronic
chr10:31628611(+) A-I      intronic
chr10:31674678(+) A-I      intronic
chr10:31718736(+) A-I      intronic
chr10:31628511(+) A-I      intronic
chr10:31628605(+) A-I      intronic
chr10:31721254(+) A-I      intronic
chr10:31626848(+) A-I      intronic
chr10:31628592(+) A-I      intronic
chr10:31718944(+) A-I      intronic
chr10:31670865(+) A-I      intronic
chr10:31636399(+) A-I      intronic
chr10:31670885(+) A-I      intronic
chr10:31674640(+) A-I      intronic
chr10:31626671(+) A-I      intronic
chr10:31674549(+) A-I      intronic
chr10:31721353(+) A-I      intronic
chr10:31670842(+) A-I      intronic
chr10:31637278(+) A-I      intronic
chr10:31628507(+) A-I      intronic
chr10:31721340(+) A-I      intronic
chr10:31670676(+) A-I      intronic
chr10:31721460(+) A-I      intronic
chr10:31721371(+) A-I      intronic
chr10:31673031(+) A-I      intronic
chr10:31616214(+) A-I      intronic
chr10:31721470(+) A-I      intronic
chr10:31721263(+) A-I      intronic
chr10:31628588(+) A-I      intronic
chr10:31721339(+) A-I      intronic
chr10:31674619(+) A-I      intronic
chr10:31770485(+) A-I      intronic
chr10:31655351(+) A-I      intronic
chr10:31628572(+) A-I      intronic
chr10:31673022(+) A-I      intronic
chr10:31670836(+) A-I      intronic
chr10:31670790(+) A-I      intronic
chr10:31788618(+) A-I      intronic
chr10:31670793(+) A-I      intronic
chr10:31673044(+) A-I      intronic
chr10:31670922(+) A-I      intronic
chr10:31670900(+) A-I      intronic
chr10:31626826(+) A-I      intronic
chr10:31670784(+) A-I      intronic
chr10:31718932(+) A-I      intronic
chr10:31673179(+) A-I      intronic
chr10:31754567(+) A-I      intronic
chr10:31673030(+) A-I      intronic
chr10:31628578(+) A-I      intronic
chr10:31753270(+) A-I      intronic
chr10:31670769(+) A-I      intronic
chr10:31628521(+) A-I      intronic
chr10:31620155(+) A-I      intronic
chr10:31628510(+) A-I      intronic
chr10:31628481(+) A-I      intronic
chr10:31721438(+) A-I      intronic
chr10:31753202(+) A-I      intronic
chr10:31721289(+) A-I      intronic
chr10:31628539(+) A-I      intronic
chr10:31657224(+) A-I      intronic
chr10:31626713(+) A-I      intronic
chr10:31626743(+) A-I      intronic
chr10:31721424(+) A-I      intronic
chr10:31637231(+) A-I      intronic
chr10:31672961(+) A-I      intronic
chr10:31628421(+) A-I      intronic
chr10:31670782(+) A-I      intronic
chr10:31626714(+) A-I      intronic
chr10:31753203(+) A-I      intronic
chr10:31670744(+) A-I      intronic
chr10:31670890(+) A-I      intronic
chr10:31670762(+) A-I      intronic
chr10:31626886(+) A-I      intronic
chr10:31670684(+) A-I      intronic
chr10:31626740(+) A-I      intronic
chr10:31670685(+) A-I      intronic
chr10:31626796(+) A-I      intronic
chr10:31637238(+) A-I      intronic
chr10:31628579(+) A-I      intronic
chr10:31670739(+) A-I      intronic
chr10:31626731(+) A-I      intronic
chr10:31626778(+) A-I      intronic
chr10:31721473(+) A-I      intronic
chr10:31628482(+) A-I      intronic
chr10:31721407(+) A-I      intronic
chr10:31670872(+) A-I      intronic
chr10:31673114(+) A-I      intronic
chr10:31670754(+) A-I      intronic
chr10:31616301(+) A-I      intronic
chr10:31673143(+) A-I      intronic
chr10:31636362(+) A-I      intronic
chr10:31670829(+) A-I      intronic
chr10:31718790(+) A-I      intronic
chr10:31628443(+) A-I      intronic
chr10:31620222(+) A-I      intronic
chr10:31718870(+) A-I      intronic
chr10:31626802(+) A-I      intronic
chr10:31636349(+) A-I      intronic
chr10:31674667(+) A-I      intronic
chr10:31626810(+) A-I      intronic
chr10:31673034(+) A-I      intronic
chr10:31626822(+) A-I      intronic
chr10:31721256(+) A-I      intronic
chr10:31718737(+) A-I      intronic
chr10:31721271(+) A-I      intronic
chr10:31718773(+) A-I      intronic
chr10:31670881(+) A-I      intronic
chr10:31718772(+) A-I      intronic
chr10:31628538(+) A-I      intronic
chr10:31626679(+) A-I      intronic
chr10:31670819(+) A-I      intronic
chr10:31673141(+) A-I      intronic
chr10:31628645(+) A-I      intronic
chr10:31718867(+) A-I      intronic
chr10:31670725(+) A-I      intronic
chr10:31670841(+) A-I      intronic
chr10:31620096(+) A-I      intronic
chr10:31636413(+) A-I      intronic
chr10:31673173(+) A-I      intronic
chr10:31754612(+) A-I      intronic
chr10:31754591(+) A-I      intronic
chr10:31672681(+) A-I      intronic
chr10:31672152(+) A-I      intronic
chr10:31754676(+) A-I      intronic
chr10:31672146(+) A-I      intronic
chr10:31680084(+) A-I      intronic
chr10:31670761(+) A-I      intronic
chr10:31801985(+) A-I      intronic
chr10:31672168(+) A-I      intronic
chr10:31626753(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED ZEB1
chr10:31626713(+) A-G intron -    22484847
chr10:31628645(+) A-G intron -    22484847
chr10:31637231(+) A-G intron -    22484847
chr10:31672961(+) A-G intron -    22484847
chr10:31718772(+) A-G intron -    22484847
chr10:31718773(+) A-G intron -    22484847
chr10:31718790(+) A-G intron -    22484847
chr10:31754567(+) A-G intron -    22484847
chr10:31754713(+) A-T intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase ZEB1
chr10:31607458-31607459(+) m6A exon       24284625//24209618//25456834//24981863//27371828//27773536
chr10:31607914-31607915(+) m6A exon       24284625//24209618//25456834//24981863//27371828//22608085
chr10:31607966-31607967(+) m6A exon       24284625//24209618//25456834//24981863
chr10:31608146-31608147(+) m6A 5'UTR//exon//intron       24981863
chr10:31608203-31608204(+) m6A CDS//exon//intron       24981863
chr10:31609058-31609059(+) m6A 5'UTR//exon//intron       24981863
chr10:31609122-31609123(+) m6A 5'UTR//exon//intron       -
chr10:31749991-31749992(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24209618//24981863
chr10:31750016-31750017(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24209618//24981863
chr10:31750037-31750038(+) m1A 3'UTR//5'UTR//CDS//exon//intron       26863196
chr10:31750097-31750098(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24209618//24981863
chr10:31750102-31750103(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24209618//24981863
chr10:31750148-31750149(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625//24209618//24981863
chr10:31750164-31750165(+) Cm 3'UTR//5'UTR//CDS//exon//intron       -
chr10:31791317-31791318(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625
chr10:31791356-31791357(+) m6A 3'UTR//5'UTR//CDS//exon//intron       24284625
chr10:31809172-31809173(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085
chr10:31809177-31809178(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085
chr10:31809184-31809185(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085
chr10:31809267-31809268(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085
chr10:31809279-31809280(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085
chr10:31809304-31809305(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085
chr10:31809309-31809310(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085
chr10:31809330-31809331(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085
chr10:31809582-31809583(+) m6A 3'UTR//CDS//exon       24981863
chr10:31809589-31809590(+) m6A 3'UTR//CDS//exon       24981863
chr10:31809670-31809671(+) m6A 3'UTR//CDS//exon       22608085
chr10:31809764-31809765(+) m6A 3'UTR//CDS//exon       24981863//22608085
chr10:31809818-31809819(+) m6A 3'UTR//CDS//exon       24209618//24981863//22608085
chr10:31810034-31810035(+) m6A 3'UTR//CDS//exon       24284625//24981863
chr10:31810118-31810119(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085
chr10:31810167-31810168(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085
chr10:31810191-31810192(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085
chr10:31810206-31810207(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085
chr10:31810235-31810236(+) m6A 3'UTR//CDS//exon       24284625//24981863//22608085
chr10:31810269-31810270(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//22608085
chr10:31810277-31810278(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//26404942//22608085
chr10:31810388-31810389(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085
chr10:31810461-31810462(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085
chr10:31810535-31810536(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085
chr10:31810560-31810561(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr10:31810568-31810569(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr10:31810601-31810602(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr10:31810616-31810617(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr10:31810623-31810624(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22575960//22608085
chr10:31810724-31810725(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085
chr10:31810827-31810828(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//22608085
chr10:31812868-31812869(+) m6A 3'UTR//CDS//exon       22608085
chr10:31812953-31812954(+) m6A 3'UTR//CDS//exon       27773535
chr10:31813021-31813022(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535
chr10:31813033-31813034(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535
chr10:31815606-31815607(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535
chr10:31815642-31815643(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085
chr10:31815648-31815649(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085
chr10:31815663-31815664(+) m6A 3'UTR//CDS//exon       24284625//24981863//27773535//22608085
chr10:31815803-31815804(+) Cm 3'UTR//CDS//exon       -
chr10:31815920-31815921(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085
chr10:31815990-31815991(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//27371828//22608085
chr10:31816028-31816029(+) m1A 3'UTR//CDS//exon       26863196
chr10:31816037-31816038(+) m1A 3'UTR//CDS//exon       26863196
chr10:31816073-31816074(+) m1A 3'UTR//CDS//exon       26863196
chr10:31816081-31816082(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//28052920//27773535//27371828//22608085
chr10:31816134-31816135(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085
chr10:31816177-31816178(+) m6A 3'UTR//CDS//exon       24284625//24209618//24981863//27773535//22608085
chr10:31816266-31816267(+) m6A 3'UTR//exon       22608085
chr10:31816317-31816318(+) m6A 3'UTR//exon       22608085
chr10:31816340-31816341(+) m6A 3'UTR//exon       24981863//22608085
chr10:31816403-31816404(+) m6A 3'UTR//exon       24981863//27773535//22608085
chr10:31816410-31816411(+) m6A 3'UTR//exon       24981863//27773535//22608085
chr10:31816446-31816447(+) m6A 3'UTR//exon       24981863//22608085
chr10:31816476-31816477(+) m6A 3'UTR//exon       24981863//22608085
chr10:31817180-31817181(+) m6A 3'UTR//exon       24981863
chr10:31817187-31817188(+) m6A 3'UTR//exon       24981863
chr10:31817208-31817209(+) m6A 3'UTR//exon       24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate ZEB1
Chromatin K562 cells     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: ZEB1

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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