Detail Information

Basic Information:


  VIRBase ID:  

VHID00505947

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           STAT1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p STAT1
miRBase
Accession/Entrez ID		 MIMAT0001581 6772
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - CANDF7//IMD31A//IMD31B//IMD31C//ISGF-3//STAT91

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR STAT1
chr2:191857962(-) A-I      intronic
chr2:191857972(-) A-I      intronic
chr2:191857971(-) A-I      intronic
chr2:191857965(-) A-I      intronic
chr2:191858040(-) A-I      intronic
chr2:191858035(-) A-I      intronic
chr2:191858030(-) A-I      intronic
chr2:191858014(-) A-I      intronic
chr2:191858007(-) A-I      intronic
chr2:191857990(-) A-I      intronic
chr2:191857979(-) A-I      intronic
chr2:191858012(-) A-I      intronic
chr2:191876684(-) A-I      intronic
chr2:191876676(-) A-I      intronic
chr2:191859560(-) A-I      intronic
chr2:191876709(-) A-I      intronic
chr2:191876773(-) A-I      intronic
chr2:191876704(-) A-I      intronic
chr2:191876242(-) A-I      intronic
chr2:191857558(-) A-I      intronic
chr2:191836430(-) A-I      intronic
chr2:191876922(-) A-I      intronic
chr2:191876966(-) A-I      intronic
chr2:191877060(-) A-I      intronic
chr2:191876947(-) A-I      intronic
chr2:191877079(-) A-I      intronic
chr2:191877055(-) A-I      intronic
chr2:191877134(-) A-I      intronic
chr2:191877059(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED STAT1
chr2:191858027(-) A-I intron -    22327324
chr2:191858032(-) A-I intron -    22327324
chr2:191858041(-) A-I intron -    22327324
chr2:191858235(-) A-I intron -    22327324
chr2:191876242(-) A-I intron -    22327324
chr2:191876947(-) A-I intron -    22327324
chr2:191857252(-) A-I intron -    21960545
chr2:191857334(-) A-I intron -    21960545
chr2:191836426(-) A-G intron -    22484847
chr2:191836428(-) G-A intron -    22484847
chr2:191836430(-) A-G intron -    22484847
chr2:191836434(-) G-A intron -    22484847
chr2:191836438(-) G-A intron -    22484847
chr2:191836442(-) A-G intron -    22484847
chr2:191853286(-) G-T intron -    22484847
chr2:191863398(-) G-T intron -    22484847
chr2:191863399(-) T-G intron -    22484847
chr2:191863407(-) G-T intron -    22484847
chr2:191863408(-) T-G intron -    22484847
chr2:191876242(-) A-G intron -    22484847
chr2:191876253(-) A-G intron -    22484847
chr2:191876277(-) A-G intron -    22484847
chr2:191876917(-) A-G intron -    22484847
chr2:191876922(-) A-G intron -    22484847
chr2:191876947(-) A-G intron -    22484847
chr2:191876966(-) A-G intron -    22484847
chr2:191877055(-) A-G intron -    22484847
chr2:191877059(-) A-G intron -    22484847
chr2:191877060(-) A-G intron -    22484847
chr2:191877079(-) A-G intron -    22484847
chr2:191877134(-) A-G intron -    22484847
chr2:191876283(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase STAT1
chr2:191833967-191833968(-) Y 3'UTR//intron       26075521
chr2:191834403-191834404(-) m6A 3'UTR//intron       26404942
chr2:191835032-191835033(-) m6A 3'UTR//intron       22575960
chr2:191835175-191835176(-) m6A 3'UTR//intron       22575960
chr2:191841603-191841604(-) m6A 3'UTR//CDS       26404942
chr2:191850374-191850375(-) m6A 3'UTR//CDS       22575960
chr2:191851628-191851629(-) m6A 3'UTR//CDS       22575960
chr2:191856027-191856028(-) m6A 3'UTR//CDS       26404942
chr2:191859822-191859823(-) m6A 3'UTR//CDS       26404942//27773535
chr2:191859840-191859841(-) m6A 3'UTR//CDS       26404942//27773535
chr2:191859860-191859861(-) m6A 3'UTR//CDS       26404942//27773535
chr2:191859878-191859879(-) m6A 3'UTR//CDS       26404942//27773535
chr2:191862584-191862585(-) m6A 3'UTR//CDS       24981863//26404942//27773535
chr2:191862640-191862641(-) m6A 3'UTR//CDS       24981863//28052920//26404942//27773535
chr2:191862661-191862662(-) m6A 3'UTR//CDS       24981863//28052920//26404942//27773535//22575960
chr2:191862691-191862692(-) m6A 3'UTR//CDS       24981863//28052920//26404942//27773535//22575960
chr2:191862990-191862991(-) m6A CDS//intron       24981863//28052920//27773535//22575960
chr2:191862996-191862997(-) m6A CDS//intron       24981863//28052920//27773535//22575960
chr2:191863025-191863026(-) m6A CDS//intron       24981863//28052920//27773535//22575960
chr2:191864356-191864357(-) m6A CDS       24981863//28052920//27773535//22575960
chr2:191864366-191864367(-) m6A CDS       24981863//28052920//27773535//22575960
chr2:191865809-191865810(-) m6A CDS       24981863//28052920//26404942//27773535//22575960
chr2:191865851-191865852(-) m6A CDS       24981863//26404942//27773535//22575960
chr2:191878510-191878511(-) m6A 5'UTR//intron       27371828
chr2:191878788-191878789(-) Y 5'UTR//intron       25219674
chr2:191878824-191878825(-) m6A 5'UTR//intron       25456834//24981863//27371828//27773536
chr2:191878831-191878832(-) m6A 5'UTR//intron       25456834//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate STAT1
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Insoluble cytoplasm HCC cell line (HepG2)     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -
Ribosome HEK-293 cells     22199352

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: STAT1

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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