Detail Information

Basic Information:


  VIRBase ID:  

VHID00505906

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           SREBF1:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p SREBF1
miRBase
Accession/Entrez ID		 MIMAT0001581 6720
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - bHLHd1//HMD//IFAP2//SREBP1

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR SREBF1
chr17:17729134(-) A-I      intronic
chr17:17729157(-) A-I      intronic
chr17:17737618(-) A-I      intronic
chr17:17737668(-) A-I      intronic
chr17:17737623(-) A-I      intronic
chr17:17736233(-) A-I      intronic
chr17:17729123(-) A-I      intronic
chr17:17729133(-) A-I      intronic
chr17:17737064(-) A-I      intronic
chr17:17733573(-) A-I      intronic
chr17:17732045(-) A-I      intronic
chr17:17732115(-) A-I      intronic
chr17:17732194(-) A-I      intronic
chr17:17732423(-) A-I      intronic
chr17:17733035(-) A-I      intronic
chr17:17733575(-) A-I      intronic
chr17:17737069(-) A-I      intronic
chr17:17737087(-) A-I      intronic
chr17:17737279(-) A-I      intronic
chr17:17737534(-) A-I      intronic
chr17:17737609(-) A-I      intronic
chr17:17737629(-) A-I      intronic
chr17:17737642(-) A-I      intronic
chr17:17738094(-) A-I      intronic
chr17:17738147(-) A-I      intronic
chr17:17738170(-) A-I      intronic
chr17:17738180(-) A-I      intronic
chr17:17737556(-) A-I      intronic
chr17:17736135(-) A-I      intronic
chr17:17736085(-) A-I      intronic
chr17:17737587(-) A-I      intronic
chr17:17732116(-) A-I      intronic
chr17:17732265(-) A-I      intronic
chr17:17736067(-) A-I      intronic
chr17:17736013(-) A-I      intronic
chr17:17732104(-) A-I      intronic
chr17:17729059(-) A-I      intronic
chr17:17733021(-) A-I      intronic
chr17:17737632(-) A-I      intronic
chr17:17733097(-) A-I      intronic
chr17:17737202(-) A-I      intronic
chr17:17729203(-) A-I      intronic
chr17:17735991(-) A-I      intronic
chr17:17738206(-) A-I      intronic
chr17:17729124(-) A-I      intronic
chr17:17736045(-) A-I      intronic
chr17:17732228(-) A-I      intronic
chr17:17737584(-) A-I      intronic
chr17:17737184(-) A-I      intronic
chr17:17737575(-) A-I      intronic
chr17:17737143(-) A-I      intronic
chr17:17737209(-) A-I      intronic
chr17:17737222(-) A-I      intronic
chr17:17737651(-) A-I      intronic
chr17:17733013(-) A-I      intronic
chr17:17733056(-) A-I      intronic
chr17:17732084(-) A-I      intronic
chr17:17737520(-) A-I      intronic
chr17:17737142(-) A-I      intronic
chr17:17737679(-) A-I      intronic
chr17:17737527(-) A-I      intronic
chr17:17732182(-) A-I      intronic
chr17:17732012(-) A-I      intronic
chr17:17732133(-) A-I      intronic
chr17:17733172(-) A-I      intronic
chr17:17731973(-) A-I      intronic
chr17:17732327(-) A-I      intronic
chr17:17732385(-) A-I      intronic
chr17:17733615(-) A-I      intronic
chr17:17737473(-) A-I      intronic
chr17:17733019(-) A-I      intronic
chr17:17737650(-) A-I      intronic
chr17:17732996(-) A-I      intronic
chr17:17737475(-) A-I      intronic
chr17:17737238(-) A-I      intronic
chr17:17737472(-) A-I      intronic
chr17:17736112(-) A-I      intronic
chr17:17733561(-) A-I      intronic
chr17:17732264(-) A-I      intronic
chr17:17736123(-) A-I      intronic
chr17:17737571(-) A-I      intronic
chr17:17732444(-) A-I      intronic
chr17:17733093(-) A-I      intronic
chr17:17733618(-) A-I      intronic
chr17:17737608(-) A-I      intronic
chr17:17738216(-) A-I      intronic
chr17:17733073(-) A-I      intronic
chr17:17737241(-) A-I      intronic
chr17:17738228(-) A-I      intronic
chr17:17737135(-) A-I      intronic
chr17:17732176(-) A-I      intronic
chr17:17733129(-) A-I      intronic
chr17:17733226(-) A-I      intronic
chr17:17732106(-) A-I      intronic
chr17:17733027(-) A-I      intronic
chr17:17737578(-) A-I      intronic
chr17:17738204(-) A-I      intronic
chr17:17733173(-) A-I      intronic
chr17:17732165(-) A-I      intronic
chr17:17737034(-) A-I      intronic
chr17:17732226(-) A-I      intronic
chr17:17736151(-) A-I      intronic
chr17:17737683(-) A-I      intronic
chr17:17737676(-) A-I      intronic
chr17:17732379(-) A-I      intronic
chr17:17736652(-) A-I      intronic
chr17:17728994(-) A-I      intronic
chr17:17733235(-) A-I      intronic
chr17:17733089(-) A-I      intronic
chr17:17736110(-) A-I      intronic
chr17:17737685(-) A-I      intronic
chr17:17737180(-) A-I      intronic
chr17:17733051(-) A-I      intronic
chr17:17735990(-) A-I      intronic
chr17:17735978(-) A-I      intronic
chr17:17737544(-) A-I      intronic
chr17:17733186(-) A-I      intronic
chr17:17737041(-) A-I      intronic
chr17:17737654(-) A-I      intronic
chr17:17737579(-) A-I      intronic
chr17:17737574(-) A-I      intronic
chr17:17733227(-) A-I      intronic
chr17:17737677(-) A-I      intronic
chr17:17729196(-) A-I      intronic
chr17:17729046(-) A-I      intronic
chr17:17738220(-) A-I      intronic
chr17:17738265(-) A-I      intronic
chr17:17731985(-) A-I      intronic
chr17:17718737(-) A-I      intronic
chr17:17724651(-) A-I      intronic
chr17:17738139(-) A-I      intronic
chr17:17732181(-) A-I      intronic
chr17:17737581(-) A-I      intronic
chr17:17733601(-) A-I      intronic
chr17:17733200(-) A-I      intronic
chr17:17732287(-) A-I      intronic
chr17:17737577(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED SREBF1
chr17:17735978(-) A-I intron -    22028664
chr17:17735990(-) A-I intron -    22028664
chr17:17735991(-) A-I intron -    22028664
chr17:17736013(-) A-I intron -    22028664
chr17:17736045(-) A-I intron -    22028664
chr17:17736067(-) A-I intron -    22028664
chr17:17736123(-) A-I intron -    22028664
chr17:17736135(-) A-I intron -    22028664
chr17:17732226(-) A-I intron -    21960545
chr17:17733601(-) A-I intron -    21960545
chr17:17737608(-) A-I intron -    21960545
chr17:17716496(-) G-A intron -    22484847
chr17:17732106(-) A-G intron -    22484847
chr17:17732265(-) A-G intron -    22484847
chr17:17737677(-) A-G intron -    22484847
chr17:17737679(-) A-G intron -    22484847
chr17:17737683(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase SREBF1
chr17:17714664-17714665(-) m6A 3'UTR       27773535
chr17:17714677-17714678(-) m6A 3'UTR       27773535
chr17:17714757-17714758(-) m6A 3'UTR       27773535
chr17:17715059-17715060(-) m6A 3'UTR//intron       24284625//27773535
chr17:17715072-17715073(-) m6A 3'UTR//intron       24284625//27773535
chr17:17715449-17715450(-) m6A 3'UTR//intron       -
chr17:17715573-17715574(-) m6A 3'UTR//intron       24284625//24981863
chr17:17715752-17715753(-) m6A 3'UTR//intron       24284625//25456834//24981863//22575960
chr17:17715833-17715834(-) m6A 3'UTR//intron       24284625//25456834//24981863//27773536//22575960
chr17:17715934-17715935(-) m6A 3'UTR//intron       24284625//27773536
chr17:17715955-17715956(-) m6A 3'UTR//CDS//intron       24284625//27773536
chr17:17716296-17716297(-) m6A 3'UTR//intron       27773536
chr17:17716316-17716317(-) m6A 3'UTR//intron       27773536
chr17:17716580-17716581(-) m6A 3'UTR//intron       -
chr17:17716738-17716739(-) m6A 3'UTR//CDS//intron       24284625//27773536//22575960
chr17:17716934-17716935(-) m6A 3'UTR//CDS       24284625//27773536//22575960
chr17:17717598-17717599(-) m6A 3'UTR//CDS       27773536//22575960
chr17:17719552-17719553(-) m6A 3'UTR//CDS//exon       22575960
chr17:17719632-17719633(-) m6A 3'UTR//CDS//exon       27773536//22575960
chr17:17719853-17719854(-) m6A 3'UTR//CDS//exon       24284625//22575960
chr17:17719928-17719929(-) m6A 3'UTR//CDS//exon       24284625//22575960
chr17:17719952-17719953(-) m6A 3'UTR//CDS//exon       24284625//22575960
chr17:17720027-17720028(-) m6A 3'UTR//CDS//exon       24284625//22575960
chr17:17720281-17720282(-) m6A 3'UTR//CDS//exon       24284625//22575960
chr17:17720505-17720506(-) m6A exon//intron       24284625
chr17:17720724-17720725(-) m6A 3'UTR//CDS//exon       24284625//22575960
chr17:17720904-17720905(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27371828//22575960
chr17:17720935-17720936(-) m6A 3'UTR//exon//intron       24284625//24981863//27371828//22575960
chr17:17721016-17721017(-) m6A CDS//exon       24284625//24981863//27371828//22575960
chr17:17721145-17721146(-) m6A CDS//exon       24284625//27371828//22575960
chr17:17721155-17721156(-) Gm CDS//exon       -
chr17:17721158-17721159(-) m6A CDS//exon       24284625//27371828//22575960
chr17:17721187-17721188(-) m6A CDS//exon       24284625//27371828//22575960
chr17:17721817-17721818(-) m6A exon//intron       -
chr17:17722018-17722019(-) m6A exon//intron       27773535
chr17:17722047-17722048(-) m6A exon//intron       27773535
chr17:17722647-17722648(-) m6A CDS//exon       22575960
chr17:17722710-17722711(-) m6A CDS//exon       22575960
chr17:17722736-17722737(-) m6A 5'UTR//CDS//exon       22575960
chr17:17723023-17723024(-) m6A 5'UTR//CDS//intron       24284625
chr17:17723106-17723107(-) m6A 5'UTR//intron       24284625
chr17:17723526-17723527(-) m6A 5'UTR//CDS//exon//intron       24284625//24981863//27773535//22575960
chr17:17723747-17723748(-) m6A 5'UTR//CDS//exon       24284625//24981863//27773535//27371828//22575960
chr17:17723807-17723808(-) m6A 5'UTR//CDS//exon       24284625//24981863//27773535//27371828
chr17:17723834-17723835(-) m6A 5'UTR//CDS//exon       24284625//24981863//27773535//27371828
chr17:17740246-17740247(-) m6A 5'UTR       24209618//25456834//24981863//27371828//27773536
chr17:17740287-17740288(-) m6A 5'UTR       24209618//25456834//24981863//27371828//27773536
chr17:17740303-17740304(-) m6A 5'UTR       25456834//24981863//27371828//27773536

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate SREBF1
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Exosome Blood     -
Membrane HCC cell line (HepG2)|K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HCC cell line (HepG2)|HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: SREBF1

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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