Basic Information:

  VIRBase ID:  

VHID00505725

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          SLC1A7:  NR_109858     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	SLC1A7
miRBase Accession/Entrez ID	MIMAT0001581	6512
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	AAAT//EAAT5

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SLC1A7	chr1:53584529(-) A-I      intronic chr1:53584521(-) A-I      intronic chr1:53584520(-) A-I      intronic chr1:53584547(-) A-I      intronic chr1:53584553(-) A-I      intronic chr1:53584558(-) A-I      intronic chr1:53584545(-) A-I      intronic chr1:53584569(-) A-I      intronic

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SLC1A7	chr1:53553274-53553275(-) m6A 3'UTR//exon       27773535 chr1:53553317-53553318(-) m6A 3'UTR//exon       27773535 chr1:53553349-53553350(-) m6A 3'UTR//exon       27773535 chr1:53553372-53553373(-) m6A 3'UTR//exon       27773535

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SLC1A7	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Exosome Blood     - Nucleus HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: SLC1A7

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.