Basic Information:

  VIRBase ID:  

VHID00505696

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          SIAH1:  NM_003031     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	SIAH1
miRBase Accession/Entrez ID	MIMAT0001581	6477
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	SIAH1A

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SIAH1	chr16:48395694(-) A-I      NonSyn:Lys->Glu chr16:48395693(-) A-I      NonSyn:Lys->Arg chr16:48395682(-) A-I      NonSyn:Asn->Asp chr16:48395683(-) A-I      Syn:Glu->Glu chr16:48395718(-) A-I      NonSyn:Ile->Val chr16:48395672(-) A-I      NonSyn:Tyr->Cys chr16:48395658(-) A-I      NonSyn:Asn->Asp chr16:48395657(-) A-I      NonSyn:Asn->Ser chr16:48395729(-) A-I      NonSyn:Gln->Arg chr16:48395704(-) A-I      NonSyn:Ile->Met chr16:48411399(-) A-I      intronic chr16:48411378(-) A-I      intronic chr16:48398025(-) A-I      intronic chr16:48398017(-) A-I      intronic chr16:48398030(-) A-I      intronic chr16:48398038(-) A-I      intronic chr16:48411767(-) A-I      intronic chr16:48411786(-) A-I      intronic chr16:48412012(-) A-I      intronic chr16:48412129(-) A-I      intronic chr16:48412019(-) A-I      intronic chr16:48412182(-) A-I      intronic chr16:48415193(-) A-I      intronic chr16:48416070(-) A-I      intronic chr16:48416085(-) A-I      intronic chr16:48412259(-) A-I      intronic chr16:48412052(-) A-I      intronic chr16:48412058(-) A-I      intronic chr16:48411406(-) A-I      intronic chr16:48411437(-) A-I      intronic chr16:48412257(-) A-I      intronic chr16:48400946(-) A-I      intronic chr16:48401062(-) A-I      intronic chr16:48411479(-) A-I      intronic chr16:48412181(-) A-I      intronic chr16:48412251(-) A-I      intronic chr16:48412152(-) A-I      intronic chr16:48403531(-) A-I      intronic chr16:48411588(-) A-I      intronic chr16:48403541(-) A-I      intronic chr16:48412116(-) A-I      intronic chr16:48411579(-) A-I      intronic chr16:48411732(-) A-I      intronic chr16:48403577(-) A-I      intronic chr16:48412220(-) A-I      intronic chr16:48416216(-) A-I      intronic chr16:48411428(-) A-I      intronic chr16:48409462(-) A-I      intronic chr16:48412046(-) A-I      intronic chr16:48411580(-) A-I      intronic chr16:48411525(-) A-I      intronic chr16:48403641(-) A-I      intronic chr16:48411533(-) A-I      intronic chr16:48414354(-) A-I      intronic chr16:48400980(-) A-I      intronic chr16:48402433(-) A-I      intronic chr16:48400905(-) A-I      intronic chr16:48400963(-) A-I      intronic chr16:48411438(-) A-I      intronic chr16:48412225(-) A-I      intronic chr16:48400981(-) A-I      intronic chr16:48411524(-) A-I      intronic chr16:48403465(-) A-I      intronic chr16:48411601(-) A-I      intronic chr16:48403571(-) A-I      intronic chr16:48411482(-) A-I      intronic chr16:48403553(-) A-I      intronic chr16:48416214(-) A-I      intronic chr16:48411467(-) A-I      intronic chr16:48414184(-) A-I      intronic chr16:48414301(-) A-I      intronic chr16:48412218(-) A-I      intronic chr16:48411562(-) A-I      intronic chr16:48410557(-) A-I      intronic chr16:48411398(-) A-I      intronic chr16:48415011(-) A-I      intronic chr16:48398043(-) A-I      intronic chr16:48402434(-) A-I      intronic chr16:48411403(-) A-I      intronic chr16:48412124(-) A-I      intronic chr16:48403446(-) A-I      intronic chr16:48401038(-) A-I      intronic chr16:48398632(-) A-I      intronic chr16:48411468(-) A-I      intronic chr16:48411367(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SIAH1	chr16:48411437(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SIAH1	chr16:48395290-48395291(-) m6A 3'UTR//intron       24981863//27773535//22608085 chr16:48395339-48395340(-) m6A 3'UTR//intron       24284625//24209618//24981863//27773535//22608085 chr16:48395382-48395383(-) m6A 3'UTR//exon//intron       24284625//24209618//24981863//27773535//27371828//22608085 chr16:48395406-48395407(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr16:48395454-48395455(-) m6A 3'UTR//exon       24284625//24209618//24981863//27773535//27371828//22575960//22608085 chr16:48395477-48395478(-) m6A 3'UTR//exon       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr16:48395699-48395700(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//27371828//22575960//22608085 chr16:48395754-48395755(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr16:48395833-48395834(-) m6A CDS       24284625//24209618//24981863//26404942//27773535//22575960//22608085 chr16:48395992-48395993(-) m6A CDS       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085 chr16:48396326-48396327(-) m6A CDS       24284625//24209618//25456834//24981863//27773535//27371828//22575960//22608085 chr16:48396407-48396408(-) m6A 5'UTR//intron       24284625//24209618//27371828//22608085 chr16:48396422-48396423(-) m6A 5'UTR//intron       22608085 chr16:48396433-48396434(-) m6A 5'UTR//intron       22608085 chr16:48396562-48396563(-) m6A 5'UTR//intron       22608085 chr16:48396678-48396679(-) m6A 5'UTR//intron       22608085 chr16:48396816-48396817(-) m6A 5'UTR//intron       22608085

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SIAH1	Chromatin K562 cells     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: SIAH1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.