Basic Information:

  VIRBase ID:  

VHID00505661

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          SRSF3:  NR_036610     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	SRSF3
miRBase Accession/Entrez ID	MIMAT0001581	6428
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	SFRS3//SRp20

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	SRSF3	chr6:36563776(+) A-I      intronic chr6:36565707(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	SRSF3	chr6:36564896(+) G-T intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	SRSF3	chr6:36562205-36562206(+) m6A 5'UTR//exon       24284625//25456834//24981863//27773535 chr6:36564564-36564565(+) m6A CDS//exon       27773535 chr6:36564594-36564595(+) m6A CDS//exon       27773535 chr6:36564640-36564641(+) m6A CDS//exon       22575960 chr6:36564669-36564670(+) m6A CDS//exon       22575960 chr6:36564735-36564736(+) Tm CDS//exon       - chr6:36566655-36566656(+) m6A 3'UTR//CDS//exon       22575960 chr6:36567974-36567975(+) m6A 3'UTR//exon//intron       24284625//24981863//27773535 chr6:36569769-36569770(+) m6A 3'UTR//exon       27773535 chr6:36569849-36569850(+) m6A 3'UTR//exon       27773535 chr6:36569911-36569912(+) m6A 3'UTR//exon       27773535 chr6:36570024-36570025(+) m6A 3'UTR//exon       27773535 chr6:36570042-36570043(+) m6A 3'UTR//exon       27773535 chr6:36570053-36570054(+) m6A 3'UTR//exon       27773535 chr6:36570061-36570062(+) m6A 3'UTR//exon       27773535 chr6:36570178-36570179(+) m6A 3'UTR//exon       26404942 chr6:36570195-36570196(+) m6A 3'UTR//exon       26404942 chr6:36570206-36570207(+) m6A 3'UTR//exon       26404942 chr6:36570943-36570944(+) m6A 3'UTR       26404942

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	SRSF3	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleolus K562 cells     - Nucleoplasm K562 cells     - Nucleus HCC cell line (HepG2)|K562 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: SRSF3

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.