Detail Information

Basic Information:


  VIRBase ID:  

VHID00505366

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           RELA:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p RELA
miRBase
Accession/Entrez ID		 MIMAT0001581 5970
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - CMCU//NFKB3//p65

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR RELA
chr11:65428693(-) A-I      intronic
chr11:65428725(-) A-I      intronic
chr11:65428675(-) A-I      intronic
chr11:65428749(-) A-I      intronic
chr11:65428674(-) A-I      intronic
chr11:65428789(-) A-I      intronic
chr11:65428714(-) A-I      intronic
chr11:65428266(-) A-I      intronic
chr11:65428244(-) A-I      intronic
chr11:65428388(-) A-I      intronic
chr11:65428701(-) A-I      intronic
chr11:65428253(-) A-I      intronic
chr11:65428375(-) A-I      intronic
chr11:65428423(-) A-I      intronic
chr11:65428779(-) A-I      intronic
chr11:65428362(-) A-I      intronic
chr11:65428639(-) A-I      intronic
chr11:65428320(-) A-I      intronic
chr11:65428686(-) A-I      intronic
chr11:65428773(-) A-I      intronic
chr11:65428717(-) A-I      intronic
chr11:65428265(-) A-I      intronic
chr11:65428352(-) A-I      intronic
chr11:65428336(-) A-I      intronic
chr11:65428453(-) A-I      intronic
chr11:65428748(-) A-I      intronic
chr11:65428697(-) A-I      intronic
chr11:65428671(-) A-I      intronic
chr11:65428386(-) A-I      intronic
chr11:65428787(-) A-I      intronic
chr11:65428345(-) A-I      intronic
chr11:65428770(-) A-I      intronic
chr11:65428666(-) A-I      intronic
chr11:65428267(-) A-I      intronic
chr11:65428762(-) A-I      intronic
chr11:65428637(-) A-I      intronic
chr11:65428579(-) A-I      intronic
chr11:65428621(-) A-I      intronic
chr11:65428598(-) A-I      intronic
chr11:65428670(-) A-I      intronic
chr11:65428566(-) A-I      intronic
chr11:65428578(-) A-I      intronic
chr11:65428574(-) A-I      intronic
chr11:65428663(-) A-I      intronic
chr11:65428447(-) A-I      intronic
chr11:65428771(-) A-I      intronic
chr11:65428716(-) A-I      intronic
chr11:65428740(-) A-I      intronic
chr11:65428342(-) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED RELA
chr11:65428663(-) A-I intron -    21960545   //22327324
chr11:65428670(-) A-I intron -    22327324
chr11:65428579(-) A-I intron -    21960545
chr11:65428598(-) A-I intron -    21960545
chr11:65428666(-) A-I intron -    21960545
chr11:65428267(-) A-G intron -    22484847
chr11:65428352(-) A-G intron -    22484847
chr11:65428386(-) A-G intron -    22484847
chr11:65428447(-) A-G intron -    22484847
chr11:65428532(-) C-T intron -    22484847
chr11:65428663(-) A-G intron -    22484847
chr11:65428666(-) A-G intron -    22484847
chr11:65428670(-) A-G intron -    22484847
chr11:65428779(-) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase RELA
chr11:65421095-65421096(-) m6A 3'UTR       24284625//24981863//28052920//27773535//27371828//22608085
chr11:65421117-65421118(-) m6A 3'UTR       24284625//24981863//28052920//27773535//27371828//22608085
chr11:65421134-65421135(-) m6A 3'UTR       24284625//24981863//28052920//27773535//27371828//22608085
chr11:65421242-65421243(-) m6A 3'UTR       24284625//24981863//27773535//22608085
chr11:65421295-65421296(-) m6A 3'UTR       24284625//24981863
chr11:65421882-65421883(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:65421888-65421889(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:65421906-65421907(-) m6A 3'UTR//CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085
chr11:65422068-65422069(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//27773535//27371828//22575960//22608085
chr11:65422110-65422111(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//27773535//27371828//22575960
chr11:65422128-65422129(-) m6A 3'UTR//CDS//exon//intron       24284625//24209618//24981863//27773535//27371828//22575960
chr11:65422158-65422159(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863//27773535//27371828
chr11:65422638-65422639(-) m6A 3'UTR//intron       27773535//27371828
chr11:65422643-65422644(-) m6A 3'UTR//intron       27773535//27371828
chr11:65422668-65422669(-) m6A 3'UTR//intron       27773535//27371828
chr11:65422751-65422752(-) m6A 3'UTR//intron       25456834//27371828
chr11:65422771-65422772(-) m6A 3'UTR//intron       25456834//27371828
chr11:65422836-65422837(-) m6A 3'UTR//intron       24284625
chr11:65422889-65422890(-) m6A 3'UTR//intron       -
chr11:65422984-65422985(-) m6A 3'UTR//intron       27371828
chr11:65423027-65423028(-) m6A 3'UTR//intron       27371828
chr11:65423065-65423066(-) m6A CDS//intron       27371828
chr11:65423085-65423086(-) m6A CDS//intron       27371828
chr11:65423340-65423341(-) m1A 3'UTR//CDS//exon//intron       26863196
chr11:65423361-65423362(-) m6A 3'UTR//CDS//exon//intron       24981863//27773535
chr11:65423370-65423371(-) m6A 3'UTR//CDS//exon//intron       27773535
chr11:65425858-65425859(-) m6A 3'UTR//CDS//exon//intron       24284625//27773535
chr11:65425874-65425875(-) m6A 3'UTR//CDS//exon//intron       24284625//27773535
chr11:65425944-65425945(-) m6A 3'UTR//CDS//exon//intron       24284625//27773535
chr11:65425966-65425967(-) m6A 3'UTR//CDS//exon//intron       27773535
chr11:65426247-65426248(-) m6A 3'UTR//CDS//exon//intron       27773535
chr11:65426253-65426254(-) m6A 3'UTR//CDS//exon//intron       27773535
chr11:65427195-65427196(-) m6A 3'UTR//CDS//exon       27773535
chr11:65427243-65427244(-) m6A 3'UTR//CDS//exon//intron       24284625//27773535
chr11:65427583-65427584(-) m6A exon//intron       27773535//27371828
chr11:65427615-65427616(-) m6A 3'UTR//CDS//exon//intron       27773535//27371828
chr11:65427647-65427648(-) m6A 3'UTR//CDS//exon//intron       27773535//27371828
chr11:65427677-65427678(-) m6A 3'UTR//CDS//exon//intron       27773535//27371828
chr11:65427707-65427708(-) m6A exon//intron       27773535//27371828
chr11:65427715-65427716(-) m6A exon//intron       27773535//27371828
chr11:65427840-65427841(-) m6A exon//intron       27773535
chr11:65427981-65427982(-) m6A exon//intron       27773535
chr11:65427999-65428000(-) m6A exon//intron       27773535
chr11:65428037-65428038(-) m6A exon//intron       27773535
chr11:65429172-65429173(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863
chr11:65429211-65429212(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863
chr11:65429253-65429254(-) m6A CDS//exon//intron       24284625//24981863
chr11:65429281-65429282(-) m6A CDS//exon//intron       24284625//24981863
chr11:65429288-65429289(-) m6A CDS//exon//intron       24284625//24981863
chr11:65429309-65429310(-) m6A CDS//exon//intron       24284625//24981863
chr11:65429366-65429367(-) m6A exon//intron       24284625//24981863
chr11:65429374-65429375(-) m6A exon//intron       24284625//24981863//27773535
chr11:65429424-65429425(-) m6A CDS//exon//intron       24284625//24981863//27773535
chr11:65429674-65429675(-) m6A 5'UTR//CDS//exon//intron       24209618//24981863//27371828
chr11:65430311-65430312(-) m6A 5'UTR//exon       24209618//24981863

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate RELA
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Human embryonic kidney cell line (HEK-293T)     30844390
Nucleus HeLa-S3 cells|K562 cells     -
Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: RELA

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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