Basic Information:

  VIRBase ID:  

VHID00505337

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          RB1:  NM_000321     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	RB1
miRBase Accession/Entrez ID	MIMAT0001581	5925
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	OSRC//p105-Rb//p110-RB1//pp110//PPP1R130//pRb//RB

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	RB1	chr13:48997124(+) A-I      intronic chr13:48997123(+) A-I      intronic chr13:48997139(+) A-I      intronic chr13:48997181(+) A-I      intronic chr13:48956188(+) A-I      intronic chr13:48978743(+) A-I      intronic chr13:48964140(+) A-I      intronic chr13:48988381(+) A-I      intronic chr13:48950557(+) A-I      intronic chr13:48950476(+) A-I      intronic chr13:48988376(+) A-I      intronic chr13:49034950(+) A-I      intronic chr13:49034887(+) A-I      intronic chr13:49034872(+) A-I      intronic chr13:49034825(+) A-I      intronic chr13:48988271(+) A-I      intronic chr13:48965708(+) A-I      intronic chr13:48978843(+) A-I      intronic chr13:49034389(+) A-I      intronic chr13:49034239(+) A-I      intronic chr13:49034206(+) A-I      intronic chr13:49034169(+) A-I      intronic chr13:49018532(+) A-I      intronic chr13:49018503(+) A-I      intronic chr13:48950580(+) A-I      intronic chr13:49008334(+) A-I      intronic chr13:48950548(+) A-I      intronic chr13:49008328(+) A-I      intronic chr13:48989662(+) A-I      intronic chr13:48989649(+) A-I      intronic chr13:48978066(+) A-I      intronic chr13:48989590(+) A-I      intronic chr13:48949792(+) A-I      intronic chr13:48950556(+) A-I      intronic chr13:48894987(+) A-I      intronic chr13:48989528(+) A-I      intronic chr13:48978039(+) A-I      intronic chr13:48965619(+) A-I      intronic chr13:48978016(+) A-I      intronic chr13:48950423(+) A-I      intronic chr13:48989667(+) A-I      intronic chr13:48950513(+) A-I      intronic chr13:48966524(+) A-I      intronic chr13:48989516(+) A-I      intronic chr13:48964138(+) A-I      intronic chr13:48966523(+) A-I      intronic chr13:48966444(+) A-I      intronic chr13:48978763(+) A-I      intronic chr13:48989509(+) A-I      intronic chr13:48880518(+) A-I      intronic chr13:48966537(+) A-I      intronic chr13:48988389(+) A-I      intronic chr13:48886111(+) A-I      intronic chr13:48966431(+) A-I      intronic chr13:48950424(+) A-I      intronic chr13:48989582(+) A-I      intronic chr13:48888750(+) A-I      intronic chr13:48966340(+) A-I      intronic chr13:48988220(+) A-I      intronic chr13:48965700(+) A-I      intronic chr13:48964139(+) A-I      intronic chr13:48965681(+) A-I      intronic chr13:48949935(+) A-I      intronic chr13:48965677(+) A-I      intronic chr13:48964143(+) A-I      intronic chr13:48989533(+) A-I      intronic chr13:48906578(+) A-I      intronic chr13:48888158(+) A-I      intronic chr13:48989596(+) A-I      intronic chr13:49034919(+) A-I      intronic chr13:49035055(+) A-I      intronic chr13:48888146(+) A-I      intronic chr13:48888092(+) A-I      intronic chr13:49034285(+) A-I      intronic chr13:48989605(+) A-I      intronic chr13:48965977(+) A-I      intronic chr13:48888067(+) A-I      intronic chr13:48950551(+) A-I      intronic chr13:49035053(+) A-I      intronic chr13:48888011(+) A-I      intronic chr13:49034386(+) A-I      intronic chr13:48950475(+) A-I      intronic chr13:48888888(+) A-I      intronic chr13:48989520(+) A-I      intronic chr13:48965613(+) A-I      intronic chr13:48989581(+) A-I      intronic chr13:48963208(+) A-I      intronic chr13:48950494(+) A-I      intronic chr13:49048387(+) A-I      intronic chr13:48965629(+) A-I      intronic chr13:48978764(+) A-I      intronic chr13:48950422(+) A-I      intronic chr13:48888848(+) A-I      intronic chr13:48965952(+) A-I      intronic chr13:48961733(+) A-I      intronic chr13:48978682(+) A-I      intronic chr13:48888790(+) A-I      intronic chr13:48989650(+) A-I      intronic chr13:49035022(+) A-I      intronic chr13:49034932(+) A-I      intronic chr13:48978719(+) A-I      intronic chr13:49034380(+) A-I      intronic chr13:48966412(+) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	RB1	chr13:48881835(+) C-A intron -    22484847 chr13:48882797(+) A-C intron -    22484847 chr13:48882798(+) C-A intron -    22484847 chr13:48888108(+) A-C intron -    22484847 chr13:48963208(+) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	RB1	chr13:48878060-48878061(+) m6A CDS//exon       24209618//24981863//27371828 chr13:48878104-48878105(+) m6A CDS//exon       24209618//27371828 chr13:48878142-48878143(+) m6A CDS//exon       24209618//27371828 chr13:48878154-48878155(+) m6A CDS//exon       24209618//27371828 chr13:48878169-48878170(+) m6A CDS//exon       24209618//27371828 chr13:48919310-48919311(+) Y CDS//exon//intron       26075521 chr13:49030412-49030413(+) m6A CDS//exon       24981863 chr13:49030436-49030437(+) m6A CDS//exon       24981863 chr13:49039177-49039178(+) Y CDS       26075521 chr13:49050836-49050837(+) m6A CDS//exon       24981863 chr13:49050925-49050926(+) m6A CDS//exon       24284625//24981863 chr13:49050937-49050938(+) m6A CDS//exon       24284625//24981863 chr13:49051493-49051494(+) m6A CDS//exon       24284625//24981863 chr13:49051526-49051527(+) m6A CDS//exon       24284625//24981863 chr13:49054144-49054145(+) m6A CDS//exon       24284625//24981863 chr13:49054190-49054191(+) m6A CDS//exon       24981863 chr13:49054217-49054218(+) m6A 3'UTR//exon       24981863 chr13:49054227-49054228(+) m6A 3'UTR//exon       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	RB1	Chromatin K562 cells     - Exosome Blood     - Nucleoplasm K562 cells     - Nucleus Colon cancer cells     24393600 Nucleus HCC cell line (HepG2)|HeLa-S3 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: RB1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.