Detail Information

Basic Information:


  VIRBase ID:  

VHID00504923

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           PLOD2:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p PLOD2
miRBase
Accession/Entrez ID		 MIMAT0001581 5352
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - BRKS2//LH2//TLH

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PLOD2
chr3:145800533(-) A-I      intronic
chr3:145800547(-) A-I      intronic

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PLOD2
chr3:145787781-145787782(-) m6A 3'UTR       26404942
chr3:145787848-145787849(-) m6A 3'UTR       26404942
chr3:145787902-145787903(-) m6A 3'UTR       27773535
chr3:145787931-145787932(-) m6A 3'UTR       27773535
chr3:145787977-145787978(-) m6A 3'UTR       27773535
chr3:145788016-145788017(-) m6A 3'UTR       27773535
chr3:145788069-145788070(-) m6A 3'UTR//exon       27773535
chr3:145788106-145788107(-) m6A 3'UTR//exon       27773535
chr3:145788177-145788178(-) m6A 3'UTR//exon       27773535
chr3:145788276-145788277(-) m6A 3'UTR//exon       24981863//27773535//22608085
chr3:145788306-145788307(-) m6A 3'UTR//exon       24284625//24981863//27773535//22608085
chr3:145788359-145788360(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr3:145788370-145788371(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr3:145788390-145788391(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr3:145788449-145788450(-) m6A 3'UTR//exon       24284625//24209618//24981863//26404942//27773535//22575960//22608085
chr3:145788538-145788539(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085
chr3:145788557-145788558(-) m6A CDS//exon       24284625//24209618//25456834//24981863//28052920//26404942//27773535//22575960//22608085
chr3:145788578-145788579(-) m6A CDS//exon       24284625//24209618//25456834//24981863//26404942//27773535//22575960//22608085
chr3:145788835-145788836(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr3:145788862-145788863(-) m6A CDS//exon       24284625//24209618//25456834//24981863//27773535//22575960//22608085
chr3:145790353-145790354(-) m6A CDS//exon       22575960
chr3:145790380-145790381(-) m6A CDS//exon       22575960
chr3:145796991-145796992(-) m6A CDS//exon       22575960
chr3:145804508-145804509(-) m6A exon//intron       24981863
chr3:145804582-145804583(-) m6A CDS//exon       24981863
chr3:145838942-145838943(-) m6A 3'UTR//CDS       24981863//26404942
chr3:145841066-145841067(-) m6A CDS//intron       24981863//26404942
chr3:145878696-145878697(-) m6A 5'UTR//CDS//intron       22575960
chr3:145878858-145878859(-) m6A 5'UTR//intron       27773536//22575960

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate PLOD2
Cytosol HCC cell line (HepG2)|HeLa-S3 cells     -
Endoplasmic reticulum Human myelogenous leukemia cell line (K-562)     21613539
Endoplasmic reticulum Human fibrosarcoma cells (HT1080)     25753659
Exosome Blood     -
Nucleus HCC cell line (HepG2)     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: PLOD2

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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