Detail Information

Basic Information:


  VIRBase ID:  

VHID00504818

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:           PFKP:      

      *It may take a few minutes to display results.

Interactor Information:


Interactor1 Interactor2
Symbol hcmv-miR-US25-1-5p PFKP
miRBase
Accession/Entrez ID
MIMAT0001581 5214
Organism Human herpesvirus 5 strain AD169 Homo sapiens
Category miRNA mRNA
Alias - ATP-PFK//PFK-C//PFK-P//PFKF

RNA Editing:


Resource Symbol Editing Position Change Genetic Region
RADAR PFKP
chr10:3175723(+) A-I      intronic
chr10:3175716(+) A-I      intronic
chr10:3131279(+) A-I      intronic
chr10:3117839(+) A-I      intronic
chr10:3117845(+) A-I      intronic
chr10:3175709(+) A-I      intronic
chr10:3131273(+) A-I      intronic
chr10:3175703(+) A-I      intronic
chr10:3117862(+) A-I      intronic
chr10:3117875(+) A-I      intronic
chr10:3131263(+) A-I      intronic
chr10:3175702(+) A-I      intronic
chr10:3131305(+) A-I      intronic
chr10:3131299(+) A-I      intronic
chr10:3131290(+) A-I      intronic
chr10:3175722(+) A-I      intronic
chr10:3164107(+) A-I      intronic
chr10:3113042(+) A-I      intronic
chr10:3140067(+) A-I      intronic
chr10:3117974(+) A-I      intronic
chr10:3116155(+) A-I      intronic
chr10:3178389(+) A-I      intronic
chr10:3117853(+) A-I      intronic
chr10:3178335(+) A-I      intronic
chr10:3144747(+) A-I      intronic
chr10:3133820(+) A-I      intronic
chr10:3144709(+) A-I      intronic
chr10:3117970(+) A-I      intronic
chr10:3164126(+) A-I      intronic
chr10:3178427(+) A-I      intronic
chr10:3118132(+) A-I      intronic
chr10:3111820(+) A-I      intronic
chr10:3116213(+) A-I      intronic
chr10:3144322(+) A-I      intronic
chr10:3144266(+) A-I      intronic
chr10:3144680(+) A-I      intronic
chr10:3144256(+) A-I      intronic
chr10:3136011(+) A-I      intronic
chr10:3135929(+) A-I      intronic
chr10:3133924(+) A-I      intronic
chr10:3133884(+) A-I      intronic
chr10:3144354(+) A-I      intronic
chr10:3133821(+) A-I      intronic
chr10:3133768(+) A-I      intronic
chr10:3117885(+) A-I      intronic
chr10:3133846(+) A-I      intronic
chr10:3133745(+) A-I      intronic
chr10:3122659(+) A-I      intronic
chr10:3122463(+) A-I      intronic
chr10:3113161(+) A-I      intronic
chr10:3144332(+) A-I      intronic
chr10:3122454(+) A-I      intronic
chr10:3144328(+) A-I      intronic
chr10:3117976(+) A-I      intronic
chr10:3111836(+) A-I      intronic
chr10:3140746(+) A-I      intronic
chr10:3133751(+) A-I      intronic
chr10:3144867(+) A-I      intronic
chr10:3113205(+) A-I      intronic
chr10:3117840(+) A-I      intronic
chr10:3117917(+) A-I      intronic
chr10:3144745(+) A-I      intronic
chr10:3113204(+) A-I      intronic
chr10:3118017(+) A-I      intronic
chr10:3144735(+) A-I      intronic
chr10:3144833(+) A-I      intronic
chr10:3117950(+) A-I      intronic
chr10:3117999(+) A-I      intronic
chr10:3116124(+) A-I      intronic
chr10:3111825(+) A-I      intronic
chr10:3124972(+) A-I      intronic
chr10:3116229(+) A-I      intronic
chr10:3144732(+) A-I      intronic
chr10:3118022(+) A-I      intronic
chr10:3145714(+) A-I      intronic
chr10:3121450(+) A-I      intronic
chr10:3145746(+) A-I      intronic
chr10:3136042(+) A-I      intronic
chr10:3144642(+) A-I      intronic
chr10:3144824(+) A-I      intronic
chr10:3144706(+) A-I      intronic
chr10:3162921(+) A-I      intronic
chr10:3113140(+) A-I      intronic
chr10:3144798(+) A-I      intronic
chr10:3113217(+) A-I      intronic
chr10:3116109(+) A-I      intronic
chr10:3139997(+) A-I      intronic
chr10:3117909(+) A-I      intronic
chr10:3125043(+) A-I      intronic
chr10:3145803(+) A-I      intronic
chr10:3113123(+) A-I      intronic
chr10:3122455(+) A-I      intronic
chr10:3111846(+) A-I      intronic
chr10:3116156(+) A-I      intronic
chr10:3175687(+) A-I      intronic
chr10:3112973(+) A-I      intronic
chr10:3117916(+) A-I      intronic
chr10:3116130(+) A-I      intronic
chr10:3144705(+) A-I      intronic
chr10:3113149(+) A-I      intronic
chr10:3162938(+) A-I      intronic
chr10:3140054(+) A-I      intronic
chr10:3113062(+) A-I      intronic
chr10:3140613(+) A-I      intronic
chr10:3133845(+) A-I      intronic
chr10:3122447(+) A-I      intronic
chr10:3168182(+) A-I      intronic
chr10:3168206(+) A-I      intronic
chr10:3168180(+) A-I      intronic
chr10:3168177(+) A-I      intronic
chr10:3168183(+) A-I      intronic
chr10:3133978(+) A-I      intronic
chr10:3168677(+) A-I      intronic
chr10:3168694(+) A-I      intronic
chr10:3168198(+) A-I      intronic
chr10:3144710(+) A-I      intronic
chr10:3168706(+) A-I      intronic
chr10:3144751(+) A-I      intronic
chr10:3167803(+) A-I      intronic
Resource Symbol Editing Position Change SeqReg exReg PMID
DARNED PFKP
chr10:3113123(+) A-I intron -    22327324
chr10:3144867(+) A-I intron -    22327324
chr10:3113123(+) A-G intron -    22484847
chr10:3118017(+) A-G intron -    22484847
chr10:3133751(+) A-G intron -    22484847
chr10:3140613(+) A-G intron -    22484847
chr10:3144833(+) A-G intron -    22484847
chr10:3144867(+) A-G intron -    22484847
chr10:3164107(+) A-G intron -    22484847
chr10:3164126(+) A-G intron -    22484847
chr10:3168677(+) A-G intron -    22484847

RNA Modification:


Resource Symbol ModificationPosition Type Genomic Context PMID
RMBase PFKP
chr10:3110849-3110850(+) m6A 5'UTR//intron       24284625//24981863
chr10:3111438-3111439(+) m6A exon//intron       24284625
chr10:3111519-3111520(+) m6A 5'UTR//exon//intron       24284625//24209618//24981863
chr10:3111561-3111562(+) m6A 5'UTR//exon//intron       24284625//24209618//24981863
chr10:3112498-3112499(+) m6A 5'UTR//intron       24284625//24209618
chr10:3141497-3141498(+) m6A CDS//exon       24284625//22575960
chr10:3146078-3146079(+) m6A CDS//exon       24284625//26404942//22575960
chr10:3147622-3147623(+) m6A CDS//exon       24284625
chr10:3147683-3147684(+) m6A CDS//exon       24284625//26404942
chr10:3149473-3149474(+) m6A CDS       24284625//26404942//22575960
chr10:3149489-3149490(+) Am CDS       -
chr10:3150958-3150959(+) m6A CDS       24284625//26404942//22575960
chr10:3151598-3151599(+) m6A CDS       24284625//22575960
chr10:3151631-3151632(+) m6A CDS       24284625//22575960
chr10:3154463-3154464(+) Y CDS       25219674
chr10:3155330-3155331(+) m6A CDS       24284625//22575960
chr10:3158985-3158986(+) m6A CDS       24284625//22575960
chr10:3159003-3159004(+) m6A CDS       24284625//22575960
chr10:3159030-3159031(+) m6A CDS       24284625//22575960
chr10:3162094-3162095(+) m6A CDS//intron       24284625//22575960
chr10:3162210-3162211(+) m6A CDS//intron       24284625//22575960
chr10:3162222-3162223(+) m6A CDS//intron       24284625//22575960
chr10:3165436-3165437(+) Am intron       -
chr10:3171305-3171306(+) m6A 5'UTR//intron       -
chr10:3171586-3171587(+) m6A 5'UTR//intron       24284625
chr10:3171602-3171603(+) m6A 5'UTR//intron       24284625
chr10:3171669-3171670(+) m6A 5'UTR//intron       24284625
chr10:3171778-3171779(+) m6A 5'UTR//intron       24284625
chr10:3171824-3171825(+) m6A 5'UTR//intron       24284625
chr10:3171894-3171895(+) m6A 5'UTR//intron       24284625
chr10:3172010-3172011(+) m6A 5'UTR//CDS       22575960
chr10:3172043-3172044(+) m6A 5'UTR//CDS       22575960
chr10:3172070-3172071(+) m6A 5'UTR//CDS       22575960
chr10:3174592-3174593(+) Gm CDS       -
chr10:3174604-3174605(+) m6A CDS       26404942//22575960
chr10:3175414-3175415(+) m6A CDS       22575960
chr10:3176702-3176703(+) m6A CDS       22575960
chr10:3176710-3176711(+) m6A CDS       22575960
chr10:3176751-3176752(+) m6A CDS       22575960
chr10:3177479-3177480(+) Y intron       25192136
chr10:3178659-3178660(+) m6A CDS//intron       26404942
chr10:3178730-3178731(+) m6A CDS//intron       26404942//22575960
chr10:3178746-3178747(+) m6A CDS//intron       26404942//22575960
chr10:3178807-3178808(+) m6A 3'UTR//intron       24284625//26404942//22575960
chr10:3178974-3178975(+) m6A 3'UTR//intron       24284625
chr10:3179762-3179763(+) m6A 3'UTR       24284625
chr10:3179777-3179778(+) m6A 3'UTR       24284625

RNA Localization:


Resource Symbol Subcellular Localization Tissue or Cell Line PMID
RNALocate PFKP
Chromatin K562 cells     -
Cytosol Human myelogenous leukemia cell line (K-562)     21613539
Cytosol HCC cell line (HepG2)     -
Exosome Blood     -
Membrane K562 cells     -
Nucleolus K562 cells     -
Nucleoplasm K562 cells     -
Nucleus Colon cancer cells     24393600
Nucleus HeLa-S3 cells|K562 cells     -

Interaction Network (The top 100 interactions):


Interactor1: hcmv-miR-US25-1-5p
Interactor2: PFKP

Evidence Support:


Strong-Evidence RISC-IP
Support Database ViRBase

References:


PMID 20585629 Target region 5'UTR
Source ViRBase Interactor1 expression None
Tissue or cell line HEK293 cells Interactor2 expression None
Description Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.

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