Basic Information:

  VIRBase ID:  

VHID00504726

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          PCDH1:  NM_001278613     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	PCDH1
miRBase Accession/Entrez ID	MIMAT0001581	5097
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	PC42//PCDH42

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PCDH1	chr5:141232956-141232957(-) m6A 3'UTR       25456834//24981863 chr5:141233042-141233043(-) m6A 3'UTR       25456834//24981863 chr5:141233147-141233148(-) m6A 3'UTR       25456834 chr5:141233184-141233185(-) m6A 3'UTR       25456834 chr5:141233511-141233512(-) m6A 3'UTR       25456834 chr5:141233667-141233668(-) m6A 3'UTR//CDS       25456834//24981863 chr5:141233674-141233675(-) m6A 3'UTR//CDS       25456834//24981863 chr5:141233709-141233710(-) m6A 3'UTR//CDS       25456834//24981863 chr5:141233784-141233785(-) m6A 3'UTR//CDS       25456834//24981863 chr5:141233790-141233791(-) m6A 3'UTR//CDS       25456834//24981863 chr5:141233841-141233842(-) m6A 3'UTR//CDS       25456834//24981863 chr5:141233867-141233868(-) m6A 3'UTR//CDS       25456834//24981863 chr5:141233887-141233888(-) m6A 3'UTR//CDS       25456834//24981863 chr5:141236980-141236981(-) m6A CDS       - chr5:141242729-141242730(-) m6A 3'UTR//CDS//exon//intron       24981863 chr5:141242872-141242873(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//27773535//22608085 chr5:141242893-141242894(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//27773535//22608085 chr5:141242908-141242909(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//27773535//22608085 chr5:141243052-141243053(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//27773535//22608085 chr5:141243169-141243170(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//27773535//27773536//22608085 chr5:141243211-141243212(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//27773536//22608085 chr5:141243218-141243219(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//27773536//22608085 chr5:141243261-141243262(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//27773536 chr5:141243403-141243404(-) m6A 3'UTR//CDS//exon//intron       25456834//24981863 chr5:141243425-141243426(-) m6A 3'UTR//CDS//exon//intron       25456834//24981863 chr5:141243452-141243453(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863 chr5:141243606-141243607(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//22608085 chr5:141243667-141243668(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//22608085 chr5:141243707-141243708(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//22608085 chr5:141243934-141243935(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//22608085 chr5:141243976-141243977(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr5:141244024-141244025(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//27773535//22575960//22608085 chr5:141244084-141244085(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//27773535//22608085 chr5:141244176-141244177(-) m6A 3'UTR//CDS//exon//intron       25456834//24981863//22608085 chr5:141244193-141244194(-) m6A 3'UTR//CDS//exon//intron       25456834//24981863//22608085 chr5:141244214-141244215(-) m6A 3'UTR//CDS//exon//intron       25456834//24981863//22608085 chr5:141244342-141244343(-) m6A 3'UTR//CDS//exon//intron       25456834 chr5:141244456-141244457(-) m6A 3'UTR//CDS//exon//intron       24284625//24981863 chr5:141244483-141244484(-) m6A 3'UTR//CDS//exon//intron       24981863 chr5:141244501-141244502(-) m6A 3'UTR//CDS//exon//intron       24981863 chr5:141244517-141244518(-) m6A 3'UTR//CDS//exon//intron       24981863 chr5:141244553-141244554(-) m6A 3'UTR//CDS//exon//intron       24981863 chr5:141244661-141244662(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//22608085 chr5:141244759-141244760(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//22608085 chr5:141244813-141244814(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//22608085 chr5:141244849-141244850(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//22608085 chr5:141244858-141244859(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//22608085 chr5:141244884-141244885(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//22608085 chr5:141244891-141244892(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//22608085 chr5:141244897-141244898(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//22608085 chr5:141244972-141244973(-) m6A 3'UTR//CDS//exon//intron       24284625//25456834//24981863//22608085 chr5:141248172-141248173(-) m6A CDS//exon       24284625//25456834//24981863 chr5:141248305-141248306(-) m6A CDS//exon       24284625//25456834//24981863//27773536//22608085 chr5:141248320-141248321(-) m6A CDS//exon       24284625//25456834//24981863//27773536//22608085 chr5:141248365-141248366(-) m6A CDS//exon       24284625//25456834//24981863//22608085 chr5:141248455-141248456(-) m6A CDS//exon       24284625//25456834//24981863//27773535//22608085 chr5:141248497-141248498(-) m6A CDS//exon       24284625//25456834//24981863//27773535 chr5:141248557-141248558(-) m6A CDS//exon       24284625//24981863//27773535 chr5:141248611-141248612(-) m6A CDS//exon       24284625//24981863//27773535 chr5:141248662-141248663(-) m6A CDS//exon       27773535 chr5:141248699-141248700(-) m6A CDS//exon       24981863 chr5:141248723-141248724(-) m6A CDS//exon       24981863 chr5:141257822-141257823(-) m6A CDS//intron       27773536 chr5:141257886-141257887(-) m6A 5'UTR//intron       27773536 chr5:141258753-141258754(-) m6A 5'UTR       24981863

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PCDH1	Cytosol Human myelogenous leukemia cell line (K-562)     21613539 Cytosol HeLa-S3 cells     - Exosome Blood     - Nucleus HeLa-S3 cells     - Ribosome Colon cancer cells     24393600

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: PCDH1

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.