Basic Information:

  VIRBase ID:  

VHID00504712

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          PAX5:  NR_103999     

      *It may take a few minutes to display results.

Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	PAX5
miRBase Accession/Entrez ID	MIMAT0001581	5079
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	ALL3//BSAP

RNA Editing:

Resource	Symbol	Editing Position	Change	Genetic Region
RADAR	PAX5	chr9:36941330(-) A-I      intronic chr9:37007975(-) A-I      intronic chr9:37013004(-) A-I      intronic chr9:36932050(-) A-I      intronic chr9:36916849(-) A-I      intronic chr9:36929820(-) A-I      intronic chr9:36918577(-) A-I      intronic chr9:36918439(-) A-I      intronic chr9:36916846(-) A-I      intronic chr9:36916744(-) A-I      intronic chr9:36918430(-) A-I      intronic chr9:36918449(-) A-I      intronic chr9:36918548(-) A-I      intronic chr9:36916714(-) A-I      intronic chr9:36909930(-) A-I      intronic chr9:36909911(-) A-I      intronic chr9:36908149(-) A-I      intronic chr9:36908146(-) A-I      intronic chr9:36908114(-) A-I      intronic chr9:36908049(-) A-I      intronic chr9:36918488(-) A-I      intronic chr9:36908048(-) A-I      intronic chr9:36908029(-) A-I      intronic chr9:36907961(-) A-I      intronic chr9:36864060(-) A-I      intronic chr9:36864011(-) A-I      intronic chr9:36931993(-) A-I      intronic chr9:36918443(-) A-I      intronic chr9:36930236(-) A-I      intronic chr9:37007974(-) A-I      intronic chr9:37007973(-) A-I      intronic chr9:36991054(-) A-I      intronic chr9:36991049(-) A-I      intronic chr9:36991024(-) A-I      intronic chr9:36990995(-) A-I      intronic chr9:36990924(-) A-I      intronic chr9:36982277(-) A-I      intronic chr9:36982198(-) A-I      intronic chr9:36973820(-) A-I      intronic chr9:36973818(-) A-I      intronic chr9:36973629(-) A-I      intronic chr9:36929838(-) A-I      intronic chr9:36863940(-) A-I      intronic chr9:36863902(-) A-I      intronic chr9:36932069(-) A-I      intronic chr9:36935338(-) A-I      intronic chr9:36935295(-) A-I      intronic chr9:36935294(-) A-I      intronic chr9:36933058(-) A-I      intronic chr9:36916770(-) A-I      intronic chr9:36952242(-) A-I      intronic chr9:36918468(-) A-I      intronic chr9:36973915(-) A-I      intronic chr9:36908120(-) A-I      intronic chr9:36918536(-) A-I      intronic chr9:37013012(-) A-I      intronic chr9:36952393(-) A-I      intronic chr9:36964088(-) A-I      intronic chr9:36908031(-) A-I      intronic chr9:36973914(-) A-I      intronic chr9:36964269(-) A-I      intronic chr9:36954036(-) A-I      intronic chr9:36932936(-) A-I      intronic chr9:36864023(-) A-I      intronic chr9:36953913(-) A-I      intronic chr9:36864006(-) A-I      intronic chr9:36908025(-) A-I      intronic chr9:36924617(-) A-I      intronic chr9:36929996(-) A-I      intronic chr9:36909999(-) A-I      intronic chr9:36944118(-) A-I      intronic chr9:36915897(-) A-I      intronic chr9:37008111(-) A-I      intronic chr9:36954012(-) A-I      intronic chr9:36915956(-) A-I      intronic chr9:36952309(-) A-I      intronic chr9:36908113(-) A-I      intronic chr9:36952333(-) A-I      intronic chr9:36949169(-) A-I      intronic chr9:36910038(-) A-I      intronic chr9:36910027(-) A-I      intronic chr9:36935265(-) A-I      intronic chr9:37008124(-) A-I      intronic chr9:36908101(-) A-I      intronic chr9:36856656(-) A-I      intronic chr9:36863417(-) A-I      intronic chr9:36949316(-) A-I      intronic chr9:36909998(-) A-I      intronic chr9:36954042(-) A-I      intronic chr9:36952352(-) A-I      intronic chr9:36935370(-) A-I      intronic chr9:36915903(-) A-I      intronic chr9:36954025(-) A-I      intronic chr9:36910013(-) A-I      intronic chr9:36929948(-) A-I      intronic chr9:36953987(-) A-I      intronic chr9:36909884(-) A-I      intronic chr9:36949067(-) A-I      intronic chr9:36953969(-) A-I      intronic chr9:36863358(-) A-I      intronic chr9:36927880(-) A-I      intronic chr9:37008324(-) A-I      intronic chr9:36951011(-) A-I      intronic chr9:36953986(-) A-I      intronic chr9:36909997(-) A-I      intronic

Resource	Symbol	Editing Position	Change	SeqReg	exReg	PMID
DARNED	PAX5	chr9:36952242(-) A-I intron -    15342557 chr9:36952309(-) A-I intron -    15342557 chr9:36952333(-) A-I intron -    15342557 chr9:36952334(-) A-I intron -    15342557 chr9:36952352(-) A-I intron -    15342557 chr9:36952385(-) A-I intron -    15342557 chr9:36952393(-) A-I intron -    15342557 chr9:36952419(-) A-I intron -    15342557 chr9:36952556(-) A-I intron -    15342557 chr9:36953002(-) A-I intron -    15342557 chr9:36953913(-) A-I intron -    15342557 chr9:36953969(-) A-I intron -    15342557   //22327324 chr9:36954012(-) A-I intron -    15342557 chr9:36954017(-) A-I intron -    15342557   //22327324 chr9:36954025(-) A-I intron -    15342557 chr9:36954036(-) A-I intron -    15342557 chr9:36954042(-) A-I intron -    15342557 chr9:36956813(-) A-I intron -    15342557 chr9:36957633(-) A-I intron -    15342557 chr9:36957887(-) A-I intron -    15342557 chr9:36941914(-) A-G intron -    22484847 chr9:36941921(-) A-G intron -    22484847 chr9:36941934(-) A-G intron -    22484847 chr9:36941940(-) A-G intron -    22484847 chr9:36941950(-) A-G intron -    22484847 chr9:36908113(-) A-G intron -    22484847 chr9:36908120(-) A-G intron -    22484847 chr9:36909989(-) A-G intron -    22484847 chr9:36918468(-) A-G intron -    22484847 chr9:36949208(-) G-T intron -    22484847 chr9:36950742(-) A-G intron -    22484847 chr9:36952334(-) A-G intron -    22484847 chr9:36952419(-) A-G intron -    22484847 chr9:36953969(-) A-G intron -    22484847 chr9:36953987(-) A-G intron -    22484847 chr9:36954017(-) A-G intron -    22484847 chr9:37013012(-) A-G intron -    22484847

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	PAX5	chr9:36837106-36837107(-) m6A 3'UTR       - chr9:36837349-36837350(-) m6A 3'UTR       28052920 chr9:36837423-36837424(-) m6A 3'UTR       28052920 chr9:36837521-36837522(-) m6A 3'UTR       28052920 chr9:36837563-36837564(-) m6A 3'UTR       28052920 chr9:36837716-36837717(-) m6A 3'UTR       - chr9:36838177-36838178(-) m6A 3'UTR       28052920 chr9:36838262-36838263(-) m6A 3'UTR       28052920 chr9:36838279-36838280(-) m6A 3'UTR       28052920 chr9:36838401-36838402(-) m6A 3'UTR       28052920 chr9:36838457-36838458(-) m6A 3'UTR       28052920 chr9:36838469-36838470(-) m6A 3'UTR       28052920 chr9:36838526-36838527(-) m6A 3'UTR       28052920 chr9:36838548-36838549(-) m6A 3'UTR       28052920 chr9:36838576-36838577(-) m6A 3'UTR       28052920 chr9:36838602-36838603(-) m6A 3'UTR       28052920 chr9:36838641-36838642(-) m6A 3'UTR       28052920 chr9:36838647-36838648(-) m6A 3'UTR       28052920 chr9:36838659-36838660(-) m6A 3'UTR       28052920 chr9:36838917-36838918(-) m6A 3'UTR       25456834 chr9:36838922-36838923(-) m6A 3'UTR       25456834 chr9:36839200-36839201(-) m6A 3'UTR       25456834//28052920 chr9:36839252-36839253(-) m6A 3'UTR       25456834//28052920 chr9:36839274-36839275(-) m6A 3'UTR       25456834//28052920 chr9:36839418-36839419(-) m6A 3'UTR       25456834//28052920 chr9:36839443-36839444(-) m6A 3'UTR       25456834//28052920 chr9:36839459-36839460(-) m6A 3'UTR       25456834//28052920 chr9:36839484-36839485(-) m6A 3'UTR       25456834//28052920 chr9:36839503-36839504(-) m6A 3'UTR       25456834//28052920 chr9:36839547-36839548(-) m6A 3'UTR       25456834//28052920 chr9:36839568-36839569(-) m6A 3'UTR       25456834//28052920 chr9:36839581-36839582(-) m6A 3'UTR       25456834//28052920 chr9:36839715-36839716(-) m6A 3'UTR       25456834//28052920 chr9:36839784-36839785(-) m6A 3'UTR       25456834//28052920 chr9:36839795-36839796(-) m6A 3'UTR       25456834//28052920 chr9:36839833-36839834(-) m6A 3'UTR       28052920 chr9:36840068-36840069(-) m6A 3'UTR       28052920 chr9:36840077-36840078(-) m6A 3'UTR       28052920 chr9:36840122-36840123(-) m6A 3'UTR       28052920 chr9:36840296-36840297(-) m6A 3'UTR       25456834//28052920 chr9:36840304-36840305(-) m6A 3'UTR       25456834//28052920 chr9:36840375-36840376(-) m6A 3'UTR       25456834//28052920 chr9:36840404-36840405(-) m6A 3'UTR       25456834//28052920 chr9:36840463-36840464(-) m6A 3'UTR       28052920 chr9:36840531-36840532(-) m6A 3'UTR//CDS       28052920

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	PAX5	Exosome Blood     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: PAX5

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.