Basic Information:

  VIRBase ID:  

VHID00504523

  Virus:  

Human herpesvirus 5 strain AD169

  Host:  

Homo sapiens

  Confidence Score:  

0.7311

  Interaction Type:  

Virus-Host interaction

  Predicted Binding:

 

      hcmv-miR-US25-1-5p:  MIMAT0001581          NFKBIE:  NM_004556     

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Interactor Information:

	Interactor1	Interactor2
Symbol	hcmv-miR-US25-1-5p	NFKBIE
miRBase Accession/Entrez ID	MIMAT0001581	4794
Organism	Human herpesvirus 5 strain AD169	Homo sapiens
Category	miRNA	mRNA
Alias	-	IKBE

RNA Modification:

Resource	Symbol	ModificationPosition	Type	Genomic Context	PMID
RMBase	NFKBIE	chr6:44226177-44226178(-) m6A 3'UTR       24209618//27773535//27371828 chr6:44226197-44226198(-) m6A 3'UTR       24209618//27773535//27371828 chr6:44226236-44226237(-) m6A 3'UTR       24209618//27773535//27371828 chr6:44226361-44226362(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr6:44226487-44226488(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22608085 chr6:44226508-44226509(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr6:44226524-44226525(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr6:44226532-44226533(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr6:44226567-44226568(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//22575960//22608085 chr6:44226588-44226589(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr6:44226608-44226609(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr6:44226632-44226633(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//26404942//27773535//27371828//22575960//22608085 chr6:44226725-44226726(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085 chr6:44226742-44226743(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085 chr6:44226790-44226791(-) m6A 3'UTR       24284625//24209618//25456834//24981863//28052920//27773535//27371828//27773536//22608085 chr6:44226846-44226847(-) m6A 3'UTR//intron       24284625//24209618//25456834//28052920//27773535//27371828//27773536//22608085 chr6:44226976-44226977(-) m6A CDS       24284625 chr6:44227792-44227793(-) m6A CDS       - chr6:44232808-44232809(-) m6A CDS       24284625//27773536 chr6:44232912-44232913(-) m6A CDS       24284625//27371828//27773536 chr6:44232924-44232925(-) m6A CDS       24284625//27371828//27773536 chr6:44233112-44233113(-) m6A 5'UTR//CDS       24209618//27371828//27773536 chr6:44233165-44233166(-) m6A 5'UTR//CDS       24209618//28052920//27371828//27773536 chr6:44233253-44233254(-) m6A 5'UTR//CDS       24209618//24981863//28052920//27371828//27773536 chr6:44233271-44233272(-) m6A 5'UTR//CDS       24209618//24981863//28052920//27371828//27773536 chr6:44233314-44233315(-) m6A 5'UTR//CDS       24209618//24981863//27371828//27773536

RNA Localization:

Resource	Symbol	Subcellular Localization	Tissue or Cell Line	PMID
RNALocate	NFKBIE	Chromatin K562 cells     - Cytosol HCC cell line (HepG2)     - Exosome Blood     - Nucleus K562 cells     -

Interaction Network (The top 100 interactions):

Interactor1: hcmv-miR-US25-1-5p
Interactor2: NFKBIE

Evidence Support:

Strong-Evidence	RISC-IP
Support Database	ViRBase

References:

PMID	20585629	Target region	5'UTR
Source	ViRBase	Interactor1 expression	None
Tissue or cell line	HEK293 cells	Interactor2 expression	None
Description	Here, we identify cellular transcript targets of one of the most highly expressed HCMV encoded miRNAs, miR-US25-1, using a recently developed biochemical approach called RISC immunoprecipitation. Strikingly, the majority of identified transcripts contained miR-US25-1 target sites within the 5'UTR rather than the 3'UTR.